Search results for "RAM"
showing 10 items of 35643 documents
Impact of Farmland Abandonment on Water Resources and Soil Conservation in Citrus Plantations in Eastern Spain
2019
Due to the reduction in the prices of oranges on the market and social changes such as the ageing of the population, traditional orange plantation abandonment in the Mediterranean is taking place. Previous research on land abandonment impact on soil and water resources has focused on rainfed agriculture abandonment, but there is no research on irrigated land abandonment. In the Valencia Region&mdash
Urban Water Pricing and Private Interests’ Lobbying in Small Rural Communities
2020
This research received funding from the LIFE programme of the European Commision [project LIFE16 ENV/ES/000196], the Regional Government of Andalusia and the European Regional Development Fund (projects P18-RT-576 and B-SEJ-018-UGR18) and the University of Granada (Plan Propio. Unidad Cientifica de Excelencia: Desigualdad, Derechos Humanos y Sostenibilidad -DEHUSO-).
Osteoclast Immunosuppressive Effects in Multiple Myeloma: Role of Programmed Cell Death Ligand 1
2018
Immunomodulatory drugs and monoclonal antibody-based immunotherapies have significantly improved the prognosis of the patients with multiple myeloma (MM) in the recent years. These new classes of reagents target malignant plasma cells (PCs) and further modulate the immune microenvironment, which prolongs anti-MM responses and may prevent tumor occurrence. Since MM remains an incurable cancer for most patients, there continues to be a need to identify new tumor target molecules and investigate alternative cellular approaches using gene therapeutic strategies and novel treatment mechanisms. Osteoclasts (OCs), as critical multi-nucleated large cells responsible for bone destruction in >80% …
Non-specific Effects of Vaccines Illustrated Through the BCG Example: From Observations to Demonstrations
2018
Epidemiological studies regarding many successful vaccines suggest that vaccination may lead to a reduction in child mortality and morbidity worldwide, on a grander scale than is attributable to protection against the specific target diseases of these vaccines. These non-specific effects (NSEs) of the Bacille Calmette-Guérin (BCG) vaccine, for instance, implicate adaptive and innate immune mechanisms, with recent evidence suggesting that trained immunity might be a key instrument at play. Collectively referring to the memory-like characteristics of innate immune cells, trained immunity stems from epigenetic reprogramming that these innate immune cells undergo following exposure to a primary…
How the knowledge of interactions between meningococcus and the human immune system has been used to prepare effective Neisseria meningitidis vaccines
2015
In the last decades, tremendous advancement in dissecting the mechanisms of pathogenicity ofNeisseria meningitidisat a molecular level has been achieved, exploiting converging approaches of different disciplines, ranging from pathology to microbiology, immunology, and omics sciences (such as genomics and proteomics). Here, we review the molecular biology of the infectious agent and, in particular, its interactions with the immune system, focusing on both the innate and the adaptive responses. Meningococci exploit different mechanisms and complex machineries in order to subvert the immune system and to avoid being killed. Capsular polysaccharide and lipooligosaccharide glycan composition, in…
Nivolumab Enhances In Vitro Effector Functions of PD-1+ T-Lymphocytes and Leishmania-Infected Human Myeloid Cells in a Host Cell-Dependent Manner
2017
Functional impairment of T-cells and a concomitant augmented expression of programmed death-1 (PD-1) have been observed in visceral leishmaniasis patients, as well as in experimental models for visceral and cutaneous leishmaniasis. The PD-1/PD-1-ligand (PD-1/PD-L) interaction negatively regulates T-cell effector functions, which are required for parasite control during leishmaniasis. The aim of this study was to elucidate the impact of the PD-1/PD-L axis in a human primary in vitro infection model of Leishmania major (Lm). Blocking the PD-1/PD-L interaction with nivolumab increased T-cell proliferation and release of the proinflammatory cytokines TNFα and IFNγ during the cocultivation of Lm…
La complejidad social de la discapacidad. Algunos ejemplos de la narración fílmica
2010
Abordar la discapacidad desde una perspectiva multidisciplinar, que recurre a la narración fílmica como método de análisis, puede ayudar a indicar la noción adecuada en referencia a esta realidad dentro de la complejidad terminológica y conceptual existente a nivel jurídico-social. Son muchas las denominaciones utilizadas, y éstas han ido variando en función de los cambios de paradigma en la materia. Se han distinguido tres modelos de tratamiento que, a su vez, han ido apareciendo en la narración fílmica: el tradicional, el médico y el social. Se enfatiza este último ya que entiende la discapacidad como el conjunto de desventajas que el individuo con deficiencias sufre cuando el entorno es…
The Strategy of Harm Reduction in Work with People Addicted to Drugs and Alcohol
2016
The policy of EU Member States, the United States, South America and Australia is heading towards the restructuring of the support system for addicts by implementing actions meant to limit the health and social damages resulting from the use of psychoactive substances. Many countries offer access to low-threshold programmes whereby the participant is not forced to maintain abstinence or submit to the excessive rules and obligations of a rehabilitation center. Harm reduction is a philosophy based on pragmatic and realistic goals of working with addicts and users. It assumes that each change, even the smallest, is important and should be supported. Harm reduction programmes usually function i…
A Conceptual Framework for Using and Evaluating Web-Based Learning Resources in School Education
2010
Published version of an article from the journal:Journal of Information Technology Education. Also available from the publisher: http://www.jite.org/documents/Vol9/JITEv9p053-079Hadjerrouit743.pdf Web-based learning resources (WBLRs) have provided teachers with a wide range of new teachingexperiences that are not possible in traditional classroom. However, little research has beendone as to which approach to WBLRs is suitable to address issues that are pertinent to learning.This paper proposes a conceptual framework to explore the design and evaluation of WBLRs inschool education. The paper also examines the way in which the framework is used to evaluatestudents? and teachers? perceptions o…
Utebarnehager – et sted for demokratisk praksis?
2013
The questions in the title is posed to discuss how an outdoor kindergarten space is contextualized and understood by those who are staying there. Nature is often seen as an especially open space, free from strong guidelines and structures. Being part of an educational practice gives the place new structures. The activities the children participate in and the employees expressed attitudes and practices are part of different discourses, which give certain limits or possibilities for what is going on at the Hut, and thus influence a democratic practice. Especially children’s play activities represent an opposition to the adult’s framing of the place. Democracy presupposes some frames, but if t…