Search results for "RAPA"

Bioengineered human bone tissue using autogenous osteoblasts cultured on different biomatrices

2003

Surgical treatment of critical-size posttraumatic bone defects is still a challenging problem, even in modern bone and joint surgery. Progress in cellular and molecular biology during the last decade now permits novel approaches in bone engineering. Recent conceptual and technical advances have enabled the use of mitotically expanded, bone-derived cells as a therapeutic approach for tissue repair. Using three different tissue carrier systems, we successfully cultivated human osteoblasts in a newly developed perfusion chamber. We studied cell proliferation and the expression of osteocalcin, osteopontin, bone morphogenetic protein-2A, alkaline phosphatase, and vascular endothelial growth fact…

Marine debris ingestion in loggerhead sea turtles, Caretta caretta, from the Western Mediterranean

2002

Marine debris represents an important threat for sea turtles, but information on this topic is scarce in some areas, such as the Mediterranean sea. This paper quantifies marine debris ingestion in 54 juvenile loggerhead sea turtles (Caretta caretta) illegally captured by fishermen in Spanish Mediterranean waters. Curved carapace length was measured, necropsies were performed and debris abundance and type was recorded. Different types of debris appeared in the gastrointestinal tract of 43 turtles (79.6%), being plastics the most frequent (75.9%). Tar, paper, Styrofoam, wood, reed, feathers, hooks, lines, and net fragments were also present. A regression analysis showed that the volume of deb…

Occurrence of Kemp's ridley sea turtle ( Lepidochelys kempii) in the Mediterranean

2008

Recent reports of Kemp's ridley sea turtle (Lepidochelys kempii) in the Western Mediterranean calls for a re-assessment of the relative importance and the presence of this species in this sea. Different hypotheses to account for the increase in reports are discussed. The present note provides a new report of the species, a juvenile of 28 cm curved carapace length caught close to Valencia (east Spain) on 16 July 2006. Conservation measures in the area should consider this species in the near future.

Stable C and N isotope concentration in several tissues of the loggerhead sea turtle Caretta caretta from the western Mediterranean and dietary impli…

2007

CONCENTRACIÓN DE ISÓTOPOS ESTABLES DE C Y N EN VARIOS TEJIDOS DE LA TORTUGA BOBA CARETTA CARETTA DEL MEDITERRÁNEO OCCIDENTAL E IMPLICACIONES SOBRE LA DIETA. – La concentración isotópica de escudos del caparazón, piel, músculo y sangre de tortuga boba (Caretta caretta) fueron analizados para investigar el patrón de variación entre tejidos y para evaluar la posición de esta especie en las redes tróficas de la cuenca Argelina. La piel presentaba valores más altos de δ13C que el músculo o los escudos del caparazón y éstos presentaban valores más altos que la sangre. En cambio, el músculo presentaba valores más altos de δ15N que la piel, ésta valores más altos que la sangre y ésta valores más al…

El marcaje revela un intercambio limitado de inmaduros de tortuga boba (<i>Caretta caretta</i>) entre regiones en el Mediterráneo occiden…

2008

Exchange of immature loggerhead sea turtles (Caretta caretta) between the northern and southern regions of the western Mediterranean was investigated using data obtained from several Spanish tagging programmes. Tagged turtles ranged in straight carapace length from 23.0 to 74.0 cm. Thirty-six turtles were recaptured after an average interval of 390.5±462.6 days (SD). As the mean dispersal distance (MDD) of a turtle population that spreads over the western Mediterranean would stabilize after 117 days (CI 95%: 98 to 149), two analyses were conducted that included data from turtles recaptured after 98 and 149 days respectively. In both analyses, turtles were recaptured more often than expected…

Astor cantaire bec-roig, Azor lagartijero oscuro (VER0000147)

1852

Altres noms vulgars: Dark Chanting-Goshawk (Anglès), Autour sombre (Francès), Graubürzel-Singhabicht (Alemany) Gabinet de Vertebrats (Departament de Zoologia), Facultat de Ciències Biològiques (Campus de Burjassot), C/ Doctor Moliner, s/n, Bloque B. 5é plant, Burjassot (Valencia). Armari: 4-1 Abisinia 09/08/1852 Macho Adulto

COMPARATIVE STUDY ON THE ELECTROPHYSIOLOGICAL EFFECTS OF MONENSIN ON ATRIAL AND VENTRICULAR MUSCLE PREPARATIONS OF GUINEA-PIG HEART

1995

The effects of monensin (10 µmol/L) alone and in presence of verapamil (3 µmol/L) or ouabuin (1 µmol/L) or glibenclamide (10 µmol/L) or BaCl2 separately were studied on the electrophysiological properties represented by force of contraction, duration of action potential, and membrane resting potential of isolated atrial and ventricular muscle of guinea –pig heart. Monensin induced a transient increase in the force of contraction of atrial and ventricular muscles. It caused a decrease in action potential duration of papillary muscle, this effect was reversed by glibenclamide. Monensin increased the action potential duration of atrial muscle in absence or presence of glibenclamide. In presenc…

Specific suppression of pentylenetetrazol-induced epileptiform discharges in CA3 neurons (hippocampal slice, guinea pig) by the organic calcium antag…

1989

Antiepileptic actions of the organic calcium antagonists flunarizine (cinnarizine derivate) and verapamil (papaverin derivat) on pentylenetetrazol-induced epileptic bioelectric activity were tested in CA3 neurones of hippocampal slices. In all experiments both calcium antagonists reduced the amplitudes and/or durations of paroxysmal depolarizations as well as their rate of occurrence, when the bath concentrations of flunarizine or verapamil exceeded 20 mumol/l. When they were added to the bath solution before pentylenetetrazol application, recordings of the resting membrane potential, of the membrane resistance, of action potentials and of spontaneous as well as of evoked excitatory and inh…

Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications

2017

Mitochondria play a key role in maintaining cellular metabolic homeostasis. These organelles have a high plasticity and are involved in dynamic processes such as mitochondrial fusion and fission, mitophagy and mitochondrial biogenesis. Type 2 diabetes is characterised by mitochondrial dysfunction, high production of reactive oxygen species (ROS) and low levels of ATP. Mitochondrial fusion is modulated by different proteins, including mitofusin-1 (MFN1), mitofusin-2 (MFN2) and optic atrophy (OPA-1), while fission is controlled by mitochondrial fission 1 (FIS1), dynamin-related protein 1 (DRP1) and mitochondrial fission factor (MFF). PARKIN and (PTEN)-induced putative kinase 1 (PINK1) partici…

Falcó selvàtic barrat, Halcón-selvático barrado (VER0000148)

Altres noms vulgars: Barred forest-falcon (Anglès), Carnifex barré (Francès), Sperberwaldfalke (Alemany) Gabinet de Vertebrats (Departament de Zoologia), Facultat de Ciències Biològiques (Campus de Burjassot), C/ Doctor Moliner, s/n, Bloque B. 5é plant, Burjassot (Valencia). Armari: 4-1 América Central Macho Adulto