Search results for "RAPA"

showing 10 items of 471 documents

Anti-inflammatory Function of High-Density Lipoproteins via Autophagy of IκB Kinase

2015

Background & Aims: Plasma levels of high-density lipoprotein (HDL) cholesterol are frequently found decreased in patients with inflammatory bowel disease (IBD). Therefore, and because HDL exerts anti-inflammatory activities, we investigated whether HDL and its major protein component apolipoprotein A-I (apoA-I) modulate mucosal inflammatory responses in vitro and in vivo. Methods: The human intestinal epithelial cell line T84 was used as the in vitro model for measuring the effects of HDL on the expression and secretion of tumor necrosis factor (TNF), interleukin-8 (IL-8), and intracellular adhesion molecule (ICAM). Nuclear factor-κB (NF-κB)-responsive promoter activity was studied by …

WT wild typeApolipoprotein BEMSA electrophoretic mobility shift assayMPO myeloperoxidaseIκB kinaseDSS dextran sodium sulphatemTOR the mammalian target of rapamycinRT-PCR real-time polymerase chain reactionNF-κBchemistry.chemical_compound540 ChemistryApoA-I apolipoprotein A-I10038 Institute of Clinical ChemistryOriginal ResearchTNF tumor necrosis factorbiologyIBD inflammatory bowel diseaseChemistryGastroenterologyMyeloperoxidase10076 Center for Integrative Human PhysiologyMEICS murine endoscopic index of colitis severityTumor necrosis factor alphalipids (amino acids peptides and proteins)3-MA 3-methyl adenineNF-κB nuclear factor κBHDL high-density lipoproteinLC3II light chain 3 IIPBS phosphate-buffered salinep-IKK phosphorylated IκB kinase610 Medicine & healthICAM intracellular adhesion molecule246-Trinitrobenzenesulfonic acidTg transgenicmedicineAutophagyCD Crohn’s disease2715 GastroenterologyColitislcsh:RC799-869KO knockoutHepatologyApolipoprotein A-IAutophagyInflammatory Bowel DiseaseTNBS 246-trinitrobenzenesulfonic acidmedicine.diseaseMolecular biologyIL interleukinsiRNA small interfering RNAPI-3 phosphatidylinositol-3Immunologybiology.protein2721 Hepatologylcsh:Diseases of the digestive system. GastroenterologyPFA paraformaldehydeLipoproteinDAPI 4′6-diamidino-2-phenylindoleCMGH Cellular and Molecular Gastroenterology and Hepatology
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Migrations of hatchling European pond turtles (Emys orbicularis) after nest emergence

2013

Distances between nest sites of Emys orbicularis and the nearest water bodies can be long. We studied whether a longer distance could affect the probability of hatchling survival, migration time, and body mass loss. In our research area (Lubuskie district, western Poland), nest sites were situated on a slope; the closest water body was in a distance of 72-290 m. Near the water body we constructed a 550 m long drift fence to recapture hatchlings migrating down the slope. We monitored 32 hatchlings from 7 different nests deposited in the years 2008-2010. The hatchlings started to emerge from their nests on 9 and 13 April 2009, 7 and 9 April 2010, 30 March, 7 and 8 April 2011. Then, hatchlings…

Water bodyNestEmys orbicularisbiologyEcologyZoologyAnimal Science and ZoologyCarapaceNest sitebiology.organism_classificationHatchlingEcology Evolution Behavior and SystematicsShort distanceAmphibia-Reptilia
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New colony of little egrets egretta garzetta at trapani saltpans

2016

Breeding on man made structures has never been cited in literature for this species. First records of breeding in windmill in the saltpans of Trapani are here reported.

Windmill breeding Egretta garzetta saltpans of Trapani Sicily.
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Specchiera, maestranze trapanesi, seconda metà XVII secolo

2013

Analisi stilistica del manufatto, già nella Collezione Whitaker, e aggiornamento bibliografico

XVII secoloTrapaniArti decorative Trapani XVII secoloArti decorativeSettore L-ART/02 - Storia Dell'Arte Moderna
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Species-specific song convergence in a moving hybrid zone between two passerines

2003

International audience; Moving hybrid zones are receiving increasing attention. However, so far little is known about the proximate mechanisms underlying these movements. Signalling behaviour, by individuals engaged in interspecific sexual and aggressive interactions, may play a crucial role. In this study, we investigated song variation within a moving hybrid zone between two warblers, Hippolais polyglotta and H. icterina . In these species, song is involved in interspecific territoriality and, probably, in mixed pairings. We showed that allopatric populations of the two species are clearly acoustically differentiated. However, interspecific differences faded out in sympatry as a result of…

[ SDE.BE ] Environmental Sciences/Biodiversity and Ecologyinterspecific interactions[SDE.MCG]Environmental Sciences/Global Changes[SDE.ES]Environmental Sciences/Environmental and Societyinterspecific territoriality[SDE.BE] Environmental Sciences/Biodiversity and Ecology[SDE.MCG] Environmental Sciences/Global Changes[ SDE.MCG ] Environmental Sciences/Global ChangesHippolaisparapatry.[SDE.ES] Environmental Sciences/Environmental and Societyparapatry[SDE.BE]Environmental Sciences/Biodiversity and Ecologyhybridization[ SDE.ES ] Environmental Sciences/Environmental and Society
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Kurzemes batolīta veidošanās

2016

Maģistra darbā – “Kurzemes batolīta veidošanās” ir analizēti Kurzemes batolītu veidojošie mezoproterozoja skābie, vidēja sastāva un bāziskie ieži, kas raksturoti pēc to ķīmiskā sastāva, struktūru un tekstūru īpatnībām, kā arī noskaidrota to hipsometriskā izvietojuma likumsakarība, raugoties no gravitācijas frakcionēšanās aspekta, kas ļauj tos raksturot kā anorogēnos apstākļos intrudējušus iežus. Balstoties uz īpatnējās tilpummasas, magnētiskās uzņēmības un iežu hipsometriskā izvietojuma kopsakarībām, noteikts, ka Kurzemes batolīts ir intrūzija ar slāņveida uzbūvi. Atslēgas vārdi: mezoproterozojs, rapakivi granīti, anortozīti, īpatnējā tilpummasa.

anortozītiĢeoloģijarapakivi-granītimezoproterozojsīpatnējā tilpummasa
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Volatile components of Centaurea calcitrapa L. and Centaurea sphaerocephala L. ssp. sphaerocephala, two Asteraceae growing wild in Sicily

2006

The volatile components of the flowerheads of Centaurea calcitrapa L. (C.c.) and Centaurea sphaerocephala L. ssp. sphaerocephala (C.s.) were obtained by hydrodistillation and identified by GC and GC–MS. Altogether 96 components were identified, 66 in C. calcitrapa and 68 in C. spaerocephala, mostly fatty acids (32.8%, C.c. and 44.2%, C.s.) and hydrocarbons (32.3%, C.c. and 15.9%, C.s.). 9,12-Octadecadienoic acid (15.8%, C.c.) and hexadecanoic acid (30.7%, C.s.) were the most abundant fatty acids; tricosane (8.0%, C.c.) and heptacosane (4.9%, C.s.) were the main hydrocarbons. Sesquiterpenes were also present as hydrocarbons (10.1% for 14 components in C.c. and 9.2% for 13 components in C.s.)…

antimicrobial activitybiologyChemistryGeneral ChemistryAsteraceaeAsteraceaebiology.organism_classificationessential oilbeta-eudesmollaw.inventionCentaurea sphaerocephala L. ssp sphaerocephalaCentaurea calcitrapaCentaurealawCentaurea calcitrapa LBotanyhexadecanoic acid912-octadecadienoic acidEssential oilFood Science
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Takrolimus w długoterminowym leczeniu immunosupresyjnym biorców przeszczepu nerki — praktyczne wskazówki

2020

Tacrolimus got the position crucial immunosuppressive drug in a solid organ transplantation. For obtaining the best long-term results it is essential an avoidance of excessive dose lowering and maintenance stable drug concentration. The intrapatient tacrolimus concentration variability, which exerts negative impact on the graft survival, should be differentiated from fluctuation, describing distinct pharmacokinetic event, without proven clinical significance. Furthermore, real tacrolimus concentration variability should be separated from variability caused by recipient instability. Among causes of tacrolimus intrapatient variability on the first places are: insufficient adherence to treatme…

appropriate dosingintrapatient concentration variabilityorgan transplantstacrolimusForum Nefrologiczne
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Piccole meraviglie in alabastro, avorio e corallo: nuove aggiunte alle arti decorative siciliane a Malta

2017

L’articolo tratta di alcune inedite opere d’arte decorativa in alabastro, avorio e corallo di collezione privata maltese che, per motivi sia tecnici che stilistico-compositivi, possono riconoscersi come manufatti trapanesi del XVIII secolo. The article deals with some unpublished alabaster, ivory and coral decorative arts kept in a Maltese private collection that, for technical and stylistic-compositional reasons, can be recognized as 18th century artifacts from Trapani.

arti decorative alabastro avorio corallo Sicilia Trapani MaltaDecorative Arts alabaster ivory coral Sicily Trapani MaltaSettore L-ART/02 - Storia Dell'Arte Moderna
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Efecto de la exposición natural al alérgeno sobre la respuesta máxima a adenosina 5’-monofosfato, concentraciones de óxido nítrico exhalado y pH del …

2014

El efecto de la exposición a los alérgenos en la capacidad de respuesta de la vía aérea y el óxido nítrico exhalado (NO) está bien documentado, pero no se dispone de información sobre los cambios inducidos por alérgenos en la meseta de la respuesta a la adenosina 5'-monofosfato (AMP), en el NO bronquial (J 'aw NO) y alveolar (CA NO), y en el atrapamiento de la vía aérea. Objetivos: Determinar el efecto de la exposición alergénica natural en la forma de la curva de concentración-respuesta a AMP, producción de NO en las vías respiratorias bronquiales y alveolares, concentración del pH del condensado del aire exhalado, y atrapamiento de la vía aérea inducido por metacolina y AMP. Métodos: Hipe…

atrapamiento de la vía aéreaUNESCO::CIENCIAS MÉDICAS::Patología::Alergias:CIENCIAS MÉDICAS::Patología::Alergias [UNESCO]adenosina 5'-monofosfatopH del condensado del aire exhaladoalérgenosmetacolinaóxido nítrico exhaladohiperrespuesta bronquial
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