Search results for "RAPTA"
showing 4 items of 4 documents
Frontiers of metal-coordinating drug design
2020
INTRODUCTION: The occurrence of metal ions in biomolecules is required to exert vital cellular functions. Metal-containing biomolecules can be modulated by small-molecule inhibitors targeting their metal-moiety. As well, the discovery of cisplatin ushered the rational discovery of metal-containing-drugs. The use of both drug types exploiting metal–ligand interactions is well established to treat distinct pathologies. Therefore, characterizing and leveraging metal-coordinating drugs is a pivotal, yet challenging, part of medicinal chemistry. AREA COVERED: Atomic-level simulations are increasingly employed to overcome the challenges met by traditional drug-discovery approaches and to compleme…
Data from: Phylogenomics of Lophotrochozoa with consideration of systematic error
2021
Phylogenomic studies have improved understanding of deep metazoan phylogeny and show promise for resolving incongruences among analyses based on limited numbers of loci. One region of the animal tree that has been especially difficult to resolve, even with phylogenomic approaches, is relationships within Lophotrochozoa (the animal clade that includes molluscs, annelids, and flatworms among others). Lack of resolution in phylogenomic analyses could be due to insufficient phylogenetic signal, limitations in taxon and/or gene sampling, or systematic error. Here, we investigated why lophotrochozoan phylogeny has been such a difficult question to answer by identifying and reducing sources of sys…
Data from: Phylogenomics of Lophotrochozoa with consideration of systematic error
2016
Phylogenomic studies have improved understanding of deep metazoan phylogeny and show promise for resolving incongruences among analyses based on limited numbers of loci. One region of the animal tree that has been especially difficult to resolve, even with phylogenomic approaches, is relationships within Lophotrochozoa (the animal clade that includes molluscs, annelids, and flatworms among others). Lack of resolution in phylogenomic analyses could be due to insufficient phylogenetic signal, limitations in taxon and/or gene sampling, or systematic error. Here, we investigated why lophotrochozoan phylogeny has been such a difficult question to answer by identifying and reducing sources of sys…
Ķīnas politiskā un ekonomiskā interese Baltijas jūras reģionā
2020
Bakalaura darba tēma ir “Ķīnas politiskā un ekonomiskā interese Baltijas jūras reģionā”. Darba mērķis ir izpētīt Ķīnas politiskās un ekonomiskās intereses Baltijas jūras reģionā, kā arī aplūkot kādi iekšēji un ārēji faktori varētu būt vadījuši līdzšinējo Ķīnas pieeju šajā reģionā. Par darba teorētisko bāzi tiks izmantota sinerģija starp defensīvā neoreālisma un konstruktīvisma teorijām, autoram tā cenšoties parādīt gan materiālos, gan ideoloģiskos apsvērumus Ķīnas rīcībai un interesēm.