Search results for "RATIONALE"
showing 10 items of 10 documents
Transgenerationale Effekte belastender Kindheitserlebnisse auf die Borderline-Symptomatik von Jugendlichen
2014
Einleitung: Bisherige Forschungsergebnisse belegen substantielle Zusammenhänge zwischen dem Erleben von Missbrauchs- und Misshandlungserfahrungen in der Kindheit und der Entwicklung der Borderline Persönlichkeitsstörung im Erwachsenenalter. Die Frage nach transgenerationalen Effekten belastender Kindheitserlebnisse sowie möglicher intermittierender Variablen wird hingegen kontrovers diskutiert. Zudem beschäftigten sich bislang wenige Studien mit der Entwicklung von Borderline Symptomen im Jugendalter. An diesen Wissenslücken ansetzend, untersuchen wir die spezifischen Effekte belastender Kindheitserfahrungen von Eltern auf Borderline-Persönlichkeitsmerkmale der Folgegeneration sowie möglich…
The dapagliflozin and prevention of adverse outcomes in chronic kidney disease (DAPA-CKD) trial: baseline characteristics
2020
Abstract Background The Dapagliflozin and Prevention of Adverse outcomes in Chronic Kidney Disease (DAPA-CKD; NCT03036150) trial was designed to assess the effect of the sodium–glucose co-transporter 2 (SGLT2) inhibitor dapagliflozin on kidney and cardiovascular events in participants with CKD with and without type 2 diabetes (T2D). This analysis reports the baseline characteristics of those recruited, comparing them with those enrolled in other trials. Methods In DAPA-CKD, 4304 participants with a urinary albumin:creatinine ratio (UACR) ≥200 mg/g and estimated glomerular filtration rate (eGFR) between 25 and 75 mL/min/1.73 m2 were randomized to dapagliflozin 10 mg once daily or placebo. Me…
Early switch to oral anticoagulation in patients with acute intermediate-risk pulmonary embolism (PEITHO-2) : a multinational, multicentre, single-ar…
2021
BACKGROUND: Current guidelines recommend a risk-adjusted treatment strategy for the management of acute pulmonary embolism. This is a particular patient category for whom optimal treatment (anticoagulant treatment, reperfusion strategies, and duration of hospitalisation) is currently unknown. We investigated whether treatment of acute intermediate-risk pulmonary embolism with parenteral anticoagulation for a short period of 72 h, followed by a switch to a direct oral anticoagulant (dabigatran), is effective and safe. METHODS: We did a multinational, multicentre, single-arm, phase 4 trial at 42 hospitals in Austria, Belgium, France, Germany, Italy, Netherlands, Romania, Slovenia, and Spain. …
Swoop: A Web Ontology Editing Browser
2006
In this paper, we describe Swoop, a hypermedia inspired Ontology Browser and Editor based on OWL, the recently standardized Web-oriented ontology language. After discussing the design rationale and architecture of Swoop, we focus mainly on its features, using illustrative examples to highlight its use. We demonstrate that with its web-metaphor, adherence to OWL recommendations and key unique features such as Collaborative Annotation using Annotea, Swoop acts as a useful and efficient web ontology development tool. We conclude with a list of future plans for Swoop, that should further increase its overall appeal and accessibility.
Zerfall der rationalen Werte, Aufgaben des Irrationalen: Brochs Dichtung als Versuch einer Sinngebung
2005
International audience
Effects of canagliflozin on serum potassium in people with diabetes and chronic kidney disease: the CREDENCE trial
2021
Abstract Aims Hyperkalaemia is a common complication of type 2 diabetes mellitus (T2DM) and limits the optimal use of agents that block the renin–angiotensin–aldosterone system, particularly in patients with chronic kidney disease (CKD). In patients with CKD, sodium‒glucose cotransporter 2 (SGLT2) inhibitors provide cardiorenal protection, but whether they affect the risk of hyperkalaemia remains uncertain. Methods and results The CREDENCE trial randomized 4401 participants with T2DM and CKD to the SGLT2 inhibitor canagliflozin or matching placebo. In this post hoc analysis using an intention-to-treat approach, we assessed the effect of canagliflozin on a composite outcome of time to eith…
Mining Creativity Research to Inform Design Rationale in Open Source Communities
2011
Design rationale can act as a creativity support tool. Recent findings from the field of creativity research present new opportunities that can guide the implementation and evaluation of design rationale’s ability to foster creative processes and outcomes. By encouraging the exploration of failure through use of analogy, design rationale can foster creative transfer and enable progress in new directions. Open source communities offer an opportunity to observe a form of intrinsically motivated ad hoc design rationale, exhibiting formal and informal information transfer links within forums and allowing access to common tools, expertise, and mentorship. A discussion of a spectrum of implementa…
The Foreign Policy of Poland and the Problem of Political Rationale
2022
The aim of the paper is to use international relations theories to explain the views of Polish elites in the field of foreign policy. The concept of political rationale in foreign policy, introduced by Fred Chernoff, is utilized to achieve this goal. The structure of the text is threefold. The first part introduces the theoretical approach. It is believed that it is possible to derive foreign policy mental maps from leading international relations theories such as realism, liberalism, and constructivism. The second part describes how foreign policy is understood by three groups of Polish elites. The third part compares decision-makers views identified in the second part with the theoretical…
Achieving both creativity and rationale : reuse in design with images and claims
2011
Although designers often try to create novel designs, many designs are based on previous work. In this paper we argue for the reuse of rationale, in the form of claims, as a central activity in design, and explore how this can be used to inspire creativity. We present a design activity in which images and claims are reused to create a storyboard and illustrate how creativity and rationale complement each other. Our work serves to demonstrate that an appropriate design activity can be used to leverage creativity with the use of rationale. peerReviewed
Collaborative Design Rational and Social Creativity in Cultures of Participation
2011
The rise in social computing has facilitated a shift from consumer cultures, focused on producing finished media to be consumed passively, to cultures of participation, where people can access the means to participate actively in personally meaningful problems. These developments represent unique and fundamental opportunities and challenges for rethinking and reinventing design rationale and creativity, as people acclimate to taking part in computer-mediated conversations of issues and their solutions. Grounded in our long-term research exploring these topics, this paper articulates arguments, describes and discusses conceptual frameworks and system developments (in the context of three cas…