Search results for "RATS"
showing 10 items of 3537 documents
Circadian variations of ?synaptic? bodies in the pineal glands of Brattleboro rats
1990
The function of the mammalian pineal gland is regulated primarily by the sympathetic system. Arginine-vasopressin (AVP) may also be involved in the regulation of pineal melatonin synthesis under experimental conditions. The present study was conducted in the AVP-deficient rat strain, the Brattleboro rat, to investigate whether the numbers and rhythms of pineal "synaptic" bodies in this strain are different from those found in intact rats. AVP or its non-vasoconstrictive analog, deamino-D-AVP, was also injected intra-arterially in Brattleboro or Sprague-Dawley rats to test whether this procedure influences "synaptic" body numbers. Brattleboro rats were killed at different time-points through…
Increased LH and FSH release from the anterior pituitary of ovariectomized rat, in vivo, by copper-, nickel-, and zinc-LHRH complexes.
1992
Abstract The effect of Cu 2+ , Ni 2+ , Zn 2+ and their complexes with LHRH on the release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) was estimated in in vivo experiments with the use of the method proposed by Ramirez and McCann. Ovariectomized, estradiol, and progesterone pretreated rats were injected intraveneously either with LHRH alone, a metal ion alone, a mixture of metal and hormone, or a metal-LHRH complex. A metal alone or a mixture of it with LHRH did not affect gonadotropin release at all or no more than LHRH alone. However, the complex of Cu 2+ with LHRH brought about a high release of LH and even higher release of FSH. This indicates that copper complex i…
Patterns matter: continuous Vs intermittent access to ethanol differently affects withdrawal behavioural phenotype and maternal care in female rats.
2014
Modeling voluntary ethanol consumption in female rats is crucial for gaining further insight in gender-related vulnerability to alcohol. Since ethanol effects depend not only on the amount consumed, but also on drinking pattern, this study aimed at assessing the influence of continuous and intermittent ethanol self-administration on peculiar aspects of female behavioural repertoire during withdrawal and relapse. Female rats undergoing a 15-week-long, 20% ethanol continuous or intermittent (3days/week) access, respectively named CARs and IARs, were tested for alcohol intake (gr/kg) and preference. During withdrawal we assessed: novelty and reward preference in novel object exploration and sa…
Aligned microcontact printing of biomolecules on microelectronic device surfaces
2001
Microcontact printing (/spl mu/CP) of extracellular matrix proteins is a fascinating approach to control cell positioning and outgrowth, which is essential in the development of applications ranging from cellular biosensors to tissue engineering. Microelectronic devices can be used to detect the activity from a large number of recording sites over the long term. However, signals from cells can only be recorded at small sensitive spots. Here, the authors present an innovative setup to perform aligned /spl mu/CP of extracellular matrix proteins on microelectronic devices in order to guide the growth of electrogenic cells specifically to these sensitive spots. The authors' system is based on t…
Due democratiche cristiane alla Consulta nazionale: Laura Bianchini e Angela Maria Guidi Cingolani
2022
Questo articolo appartiene a uno studio più ampio che mira a ricostruire una tradizione politica femminile per comprendere alcune delle ragioni persistenti dietro il divario di genere tra accesso formale e sostanziale alle decisioni. L’obiettivo finale è quello di evidenziare il ruolo e il contributo delle donne, soprattutto di quelle che sono finite nell’oblio, nella costituzione di un’Italia democratica e repubblicana fin dalle loro prime partecipazioni all’Assemblea Nazionale Consultiva. L’Archivio della Camera dei Deputati, l’Archivio dell’Istituto Sturzo e gli articoli delle riviste dell’epoca sono state le fonti primarie della ricerca.Il 25 settembre 1945 si inaugura la Consulta che r…
"Les contrats du commerce équitable"
2006
National audience
Effect of cytochrome P450 inhibitors (diethyl dithiocarbamate, ketoconazole and grapefruit juice) on the pharmacokinetics of all-trans-retinoic acid.
2004
Diethyl dithiocarbamate (DEDTC) has been reported to be a more powerful inhibitor of all-trans-retinoic acid (ATRA) in vitro metabolism than the well-established cytochrome P450 (CYP) inhibitor ketoconazole (KC). In recent years grapefruit juice (GJ) has been shown to be able to increase the oral bioavailability of several drugs by inhibiting intestinal CYP. This study investigated the in vivo effect of these CYP inhibitors on the pharmacokinetics of ATRA. The latter was administered to rats as a constant-rate intravenous (i.v.) infusion (0.48 mg h(-1) kg(-1)) during 10 h and orally (1.6 mg kg(-1)). DEDTC (320 mg kg(-1) x 2 i.v., 6.4 and 32 mg kg(-1) per os (p.o.)) did not change the ATRA c…
Light-dependent CK2-mediated phosphorylation of centrins regulates complex formation with visual G-protein.
2008
AbstractCentrins are Ca2+-binding EF-hand proteins. All four known centrin isoforms are expressed in the ciliary apparatus of photoreceptor cells. Cen1p and Cen2p bind to the visual G-protein transducin in a strictly Ca2+-dependent way, which is thought to regulate light driven movements of transducin between photoreceptor cell compartments. These relatively slow motile processes represent a novel paradigm in light adaptation of photoreceptor cells.Here we validated specific phosphorylation as a novel regulator of centrins in photoreceptors. Centrins were differentially phosphorylated during photoreceptor dark adaptation. Inhibitor treatments revealed protein kinase CK2 as the major protein…
1,4 dihidropiridinski derivati povećavaju ekspresiju gena Psma3, Psmb5 i Psmc6 u glasničkoj RNA štakora
2021
The ubiquitin-proteasome system modifies different cellular and protein functions. Its dysregulation may lead to disrupted proteostasis associated with multiple pathologies and aging. Pharmacological regulation of proteasome functions is already an important part of the treatment of several diseases. 1,4-dihydropyridine (1,4-DHP) derivatives possess different pharmacological activities, including antiaging and neuroprotective. The aim of this study was to investigate the effects of several 1,4-DHP derivatives on mRNA expression levels of proteasomal genes Psma3, Psmb5, and Psmc6 in several organs of rats. Rats were treated with metcarbatone, etcarbatone, glutapyrone, styrylcarbatone, AV-153…
Esteratsastuksen lajianalyysi ja valmennuksen perusteet
2013
Tämän työn tarkoituksena oli koota tietoa esteratsastuksessa tarvittavista eri osa-alueista kuten biomekaniikasta ja fysiologiasta ratsastajan sekä osittain myös hevosen näkökulmasta. Työ käsittelee myös valmennusjärjestelmää, harjoittelun ohjelmointia, kilparatsastajan urapolkua (SRL 2012c), ravinnon merkitystä ratsastajalle sekä ratsastajan kuntotestausta, joka on vielä lajissa kohtalaisen uutta. Työ perustuu sekä tieteellisiin julkaisuihin, ammattilaisten luentoihin että henkilökohtaisiin tiedonantoihin. Esteratsastus on yksi vanhimmista ratsastuksen kilpailumuodoista. Esteratsastuksessa ratsukon eli hevosen ja ratsastajan tehtävänä on ylittää kilpailuradalle ratamestarin suunnittelemat,…