Search results for "RAV"

Intraventricular insulin decreases kappa opioid-mediated sucrose intake in rats.

2002

The hormone insulin acts in the central nervous system (CNS) as a regulator of body adiposity and food intake. Recent work from our laboratory has provided evidence that one way by which insulin may decrease food intake is by decreasing the rewarding properties of food. Evidence from others suggests that endogenous opioids may mediate the palatable properties of foods, and insulin may decrease nonfood-related reward via interaction with some CNS kappa opioid systems. In the present study we examined the ability of insulin to interact with exogenous or endogenous kappa opioids to modulate feeding of palatable sucrose pellets by nondeprived rats. Insulin (5 mU intracerebroventricular (i.c.v.)…

Effect of adolescent exposure to WIN 55212-2 on the acquisition and reinstatement of MDMA-induced conditioned place preference.

2009

The present study employs a conditioned place preference procedure (CPP) to examine the effects of exposure to the cannabinoid agonist WIN 55212-2 (WIN) (0.1 and 0.5mg/kg) during adolescence on the reinforcing properties of +/-3,4-methylenedioxymetamphetamine hydrochloride (MDMA) (1.25 and 2.5mg/kg) in mice. On postnatal day (PD) 27, animals received a daily injection of the assigned treatment on 5 consecutive days, and three days later the place conditioning procedure was initiated (PD 35). The results suggest that pre-exposure to cannabinoids strengthens the properties of MDMA and favors reinstatement of the craving for the drug, which endorses the gateway hypothesis.

Endothelin Antagonism: Effects of FP Receptor Agonists Prostaglandin F2αand Fluprostenol on Trabecular Meshwork Contractility

2006

Purpose This study analyzes additional mechanisms behind the ocular hypotensive effect of prostaglandin F (PGF) receptor (FP receptor) agonists PGF2alpha and fluprostenol (fluprostenol-isopropyl ester [travoprost]), which reduce intraocular pressure (IOP) in patients with glaucoma probably by enhancing uveoscleral flow. The trabecular meshwork (TM) is actively involved in IOP regulation through contractile mechanisms. Contractility of TM is induced by endothelin (ET)-1, a possible pathogenic factor in glaucoma. The involvement of FP receptor agonists in the ET-1 effects on TM function was studied. Methods The effects of FP receptor agonists on contractility of bovine TM (BTM) were investiga…

GABA, receptor mediated fast synaptic inhibition in the rabbit brain-stem respiratory system

1991

The involvement of GABA mediated neurotransmission in the central control of respiration was investigated by administration of the specific GABAA receptor agonist muscimol and the specific GABAA receptor antagonist biculline into the fourth cerebral ventricle of the rabbit. Cycle-triggered averaging of the phrenic nerve activity (PNA) was used to quantify drug-induced changes of the central respiratory pattern. Muscimol reduced the peak amplitude of PNA and increased the duration of the respiratory phases. High amounts of muscimol led to a long-lasting but reversible central apnea. Bicuculline very effectively blocked the effects of externally applied muscimol. Blockade of intrinsically act…

Exercise as an Adjuvant Intervention in Opiate Dependence

2013

We read with interest the article by Weinstock et al. in whichthe authors propose exercise as an adjuvant intervention inopiate agonist treatment based on current research findings(1).The use of an opiate agonist, such as buprenorphine, butmainly, methadone, for the treatment of opiate dependenceis currently an effective therapy for this type of addiction.The main benefits of this treatment occur through a relieffrom craving narcotic drugs, a temporally suppression ofwithdrawal symptoms, and by blocking the euphoric effectsof opiates (2). Unfortunately, patients needing treatment foropiatedependenceoftenfaceavarietyofco-occurringissues,suchashepatitisBandCvirusesorhumanimmunodeficiencyvirus (H…

Examining the effects of birth order on personality.

2015

This study examined the long-standing question of whether a person’s position among siblings has a lasting impact on that person’s life course. Empirical research on the relation between birth order and intelligence has convincingly documented that performances on psychometric intelligence tests decline slightly from firstborns to laterborns. By contrast, the search for birth-order effects on personality has not yet resulted in conclusive findings. We used data from three large national panels from the United States (N = 5,240), Great Britain (N = 4,489), and Germany (N = 10,457) to resolve this open research question. This data base allowed us to identify even very small effects of birth o…

Mothers' and fathers' personality and parenting: the mediating role of sense of competence.

2009

This prospective longitudinal study addressed 3 key questions regarding the processes of parenting in a large community sample of mothers (n = 589) and fathers (n = 518). First, the collective impact of parental Big Five personality dimensions on overreactive and warm parenting, assessed 6 years later by adolescents, was examined. Second, mediation of these associations by sense of competence in the parenting role was addressed. Third, it was explored to what extent associations were similar for mothers and fathers. Agreeableness and Extraversion were related to lower levels of overreactivity and higher levels of warmth. Sense of competence completely mediated relations between personality …

2021

Gambling may range from being a recreational leisure activity to a behavioral addiction. A rising number of gamblers experience adverse consequences from gambling, termed problem gambling, which may become a challenge for the individual and society. With the present research, we aimed to investigate the correlates of problem gambling. We used a large sample of more than 12,500 individuals (46% male, Mage = 48, SDage = 18) from the Household, Income, and Labour Dynamics in Australia (HILDA) Survey and analyzed sociodemographic and personality variables (Big Five, locus of control) as well as the extent of problem gambling. Findings showed that male sex and a lower level of education were rel…

Perfil de personalidad vulnerable en pacientes con dolor crónico: relación con el afrontamiento, la calidad de vida y la adaptación a la enfermedad

2012

In this study with a sample of chronic pain patient, personality profiles defined as the individual’s scores on all five dimensions (NEO-FFI) are used, to establish relations with coping, quality of life, and adaptation to disease. After a cluster analysis two groups have been obtained: the first one being a trend to intermediate scores in all five dimensions and characterized by moderate neuroticism, average extraversion, low openness, moderate agreeableness, and moderate conscientiousness, whereas the second one is characterized by traits of vulnerability determined by high neuroticism, low extraversion, low openness, moderate agreeableness and low conscientiousness. Significant univariat…

Uso problemático del smartphone: el papel de los Cinco Grandes, la Tríada Oscura y la impulsividad

2021

Abstract. Este estudio examinó las relaciones entre los rasgos de personalidad de los cinco grandes (extraversión, afabilidad, neuroticismo, responsabilidad y apertura a la experiencia), la tríada oscura (maquiavelismo, psicopatía y narcisismo), la impulsividad y el uso problemático del smartphone. Doscientos dos participantes (52.48% hombres), con edades comprendidas entre los 18 y los 58 años, completaron el Ten-Item Personality Inventory, la Smartphone Addiction Scale, el Dirty Dozen y la escala de impulsividad de Plutchik. Los análisis de correlación mostraron que el uso problemático del smartphone estaba significativamente asociado a la extraversión, el neuroticismo, la impulsividad y …