Search results for "RAV"
showing 10 items of 5866 documents
The Impact of Amino Acids on Postprandial Glucose and Insulin Kinetics in Humans
2020
Different amino acids (AAs) may exert distinct effects on postprandial glucose and insulin concentrations. A quantitative comparison of the effects of AAs on glucose and insulin kinetics in humans is currently lacking. PubMed was queried to identify intervention studies reporting glucose and insulin concentrations after acute ingestion and/or intravenous infusion of AAs in healthy adults and those living with obesity and/or type 2 diabetes (T2DM). The systematic literature search identified 55 studies that examined the effects of l-leucine, l-isoleucine, l-alanine, l-glutamine, l-arginine, l-lysine, glycine, l-proline, l-phenylalanine, l-glutamate, branched-chain AAs (i.e., l-leucine, l-iso…
Non lipid, dose-dependent effects of pravastatin treatment on hemostatic system and inflammatory response
2000
Objectives: The aim of the present study was to evaluate the effects of pravastatin treatment on lipid, inflammation, and coagulation parameters in patients suffering from myocardial infarction with or without carotid atherosclerotic lesions (groups 1 and 2, respectively). Methods: In the first phase of the study, a cross-sectional comparison of lipid, inflammation, and coagulation parameters was performed between the patients and the control group (group 3). Highly significant differences in these parameters were observed, especially in group 1. In the second phase of the study, we assessed the effects of a persistent reduction in cholesterol synthesis induced by increasing doses of pravas…
Platelet, Not Endothelial, P-Selectin Expression Contributes to Generation of Immunity in Cutaneous Contact Hypersensitivity
2010
Leukocyte extravasation is a prerequisite for host defense and autoimmunity alike. Detailed understanding of the tightly controlled and overlapping sequences of leukocyte extravasation might aid development of novel therapeutic strategies. Leukocyte extravasation is initiated by interaction of selectins with appropriate carbohydrate ligands. Lack of P-selectin expression leads to decreased contact hypersensitivity responses. Yet, it remains unclear if this is due to inhibition of leukocyte extravasation to the skin or due to interference with initial immune activation in lymph nodes. In line with previous data, we here report a decreased contact hypersensitivity response, induced by 2,4,-di…
Blood flow patterns spatially associated with platelet aggregates in murine colitis.
2009
In the normal murine mucosal plexus, blood flow is generally smooth and continuous. In inflammatory conditions, such as chemically-induced murine colitis, the mucosal plexus demonstrates markedly abnormal flow patterns. The inflamed mucosal plexus is associated with widely variable blood flow velocity as well as discontinuous and even bidirectional flow. To investigate the mechanisms responsible for these blood flow patterns, we used intravital microscopic examination of blood flow within the murine mucosal plexus during dextran sodium sulphate-and trinitrobenzenesulfonic acid-induced colitis. The blood flow patterns within the mucosal plexus demonstrated flow exclusion in 18% of the vessel…
In-vitro test system for the evaluation of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibitors based on a single HPLC run with UV detect…
2001
Objective and Design: The aim of this study was to develop a new, whole-cell test system which is easy to handle and requires a standard equipment for the parallel screening of COX-1 and COX-2 inhibitors.¶Materials: Bovine aortic endothelial cells (BAECs).¶Treatment and methods: Unstimulated bovine aortic coronary endothelial cells (BAECs) were used as a source of COX-1 and BAECs pretreated with ASA (100 μM) and activated with phorbol myristate acetate (PMA) were used as a source of COX-2. The time- and concentration-dependent induction of COX-2 expression in the BAECs was evaluated by a kinetic profile (HPLC analysis) and detected by Western-Blot analysis using polyclonal antibodies agains…
Rethinking Regional Competitiveness: Catalonia's International and Interregional Trade 1995-2006
2009
Studies of competitiveness tend to focus on a local economy's global interactions, particularly its international trade. But for countries that are at least mid-sized (such as Spain), interregional trade tends to be as large as or significantly larger than international trade. The case of Catalonia illustrates the importance of interregional flows in truly analyzing and devising strategies for a region's external competitiveness. Accounting for interregional trade changes and performing analyses of Catalonia's overall merchandise trade balance, which sectors generate external surpluses as opposed to deficits, and who Catalonia's key trading partners are, and the use of a gravity-model appro…
Time-dependent asymmetric traveling salesman problem with time windows: Properties and an exact algorithm
2019
Abstract In this paper, we deal with the Time-Dependent Asymmetric Traveling Salesman Problem with Time Windows. First, we prove that under special conditions the problem can be solved as an Asymmetric Traveling Salesman Problem with Time Windows, with suitable-defined time windows and (constant) travel times. Second, we show that, if the special conditions do not hold, the time-independent optimal solution provides both a lower bound and (eventually) an upper bound with a worst-case guarantee for the Time-Dependent Asymmetric Traveling Salesman Problem with Time Windows. Finally, a branch-and-bound algorithm is presented and tested on a set of 4800 instances. The results have been compared…
Two episodes of Taravana syndrome in a breath-hold diver with hyperhomocysteinemia
2018
Key Clinical Message Taravana syndrome is a rare dysbaric disease characterized by neurologic signs and symptoms. Differently from others decompression illness, it has unspecified pathophysiology and unclear predisposing factors. Our cases suggest that thrombophilic state due to hyperhomocysteinemia could increase the risk to develop Taravana syndrome.
Halloysite nanotubes loaded with peppermint essential oil as filler for functional biopolymer film
2016
Abstract The purpose of this paper is to show how a functional bionanocomposite film with both antioxidant and antimicrobial activities was successfully prepared by the filling of a pectin matrix with modified Halloysite nanotubes (HNT) containing the essential peppermint oil (PO). Firstly, HNT surfaces were functionalized with cucurbit[6]uril (CB[6]) molecules with the aim to enhance the affinity of the nanofiller towards PO, which was estimated by means of HPLC experiments. The HNT/CB[6] hybrid was characterized by several methods (thermogravimetry, FT-IR spectroscopy and scanning electron microscopy) highlighting the influence of the supramolecular interactions on the composition, therma…
UV-PHOTOMETRY WITH THE 1.2 M SCHMIDT TELESCOPE IN BALDONE
2016
TheUniversityofLatvia's Institute of astronomy possesses a collection of 22 thousand photographic plates taken by the1.2 mSchmidt telescope located at the Baldone observatory. Among others, there are 767 astronegatives in this collection obtained in 314 sky areas using the Johnson U-filter. The field of view of each negative covers 19 square degrees. The plate scale is 72”/mm. The digitizing of the UV-collection has started in June 2016 with EPSON EXPRESSION 10000XL flatbed scanner. The general aim of the digitizing is to obtain UV-magnitudes and positions of all objects registered on the plates. Up to date near a half of the UV-collection is digitized. 24 digitized MEGA program plates of t…