Search results for "RC705"

showing 10 items of 70 documents

Extracorporeal Shock Waves Increase Markers of Cellular Proliferation in Bronchial Epithelium and in Primary Bronchial Fibroblasts of COPD Patients

2020

Chronic obstructive pulmonary disease (COPD) is due to structural changes and narrowing of small airways and parenchymal destruction (loss of the alveolar attachment as a result of pulmonary emphysema), which all lead to airflow limitation. Extracorporeal shock waves (ESW) increase cell proliferation and differentiation of connective tissue fibroblasts. To date no studies are available on ESW treatment of human bronchial fibroblasts and epithelial cells from COPD and control subjects. We obtained primary bronchial fibroblasts from bronchial biopsies of 3 patients with mild/moderate COPD and 3 control smokers with normal lung function. 16HBE cells were also studied. Cells were treated with a…

Extracorporeal Shockwave TherapyMalePathologyPulmonary Disease Chronic Obstructive0302 clinical medicineMedicine0303 health sciencesCOPDSmokersbiologyCell DifferentiationMiddle AgedProto-Oncogene Proteins c-kitmedicine.anatomical_structurepsychological phenomena and processesResearch ArticlePulmonary and Respiratory MedicineExtracorporeal Shock Waves COPDCell typemedicine.medical_specialtyArticle SubjectPrimary Cell CultureeducationConnective tissueBronchibehavioral disciplines and activitiesCollagen Type ICell LineTransforming Growth Factor beta1Diseases of the respiratory system03 medical and health sciencesProliferating Cell Nuclear AntigenParenchymaHumansCD90RNA MessengerAgedCell Proliferation030304 developmental biologyRC705-779business.industryCD117Cell growthTranscription Factor RelAEpithelial CellsFibroblastsmedicine.diseaserespiratory tract diseasesProliferating cell nuclear antigen030228 respiratory systemCase-Control Studiesbiology.proteinbusiness
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Circadian rhythm of COPD symptoms in clinically based phenotypes. Results from the STORICO Italian observational study

2019

Abstract Background Chronic Obstructive Pulmonary Disease (COPD) encompasses various phenotypes that severely limit the applicability of precision respiratory medicine. The present investigation is aimed to assess the circadian rhythm of symptoms in pre-defined clinical COPD phenotypes and its association with health-related quality of life (HR-QoL), the quality of sleep and the level of depression/anxiety in each clinical phenotype. Methods The STORICO (NCT03105999) Italian observational prospective cohort study enrolled COPD subjects. A clinical diagnosis of either chronic bronchitis (CB), emphysema (EM) or mixed COPD-asthma (MCA) phenotype was made by clinicians at enrollment. Baseline e…

MaleChronic bronchitisTime FactorsHealth StatusAnxietyHospital Anxiety and Depression ScaleSeverity of Illness IndexHealth StatuPulmonary Disease Chronic Obstructive0302 clinical medicineSurveys and QuestionnairesForced Expiratory VolumeClinical phenotypeMedicineSurveys and QuestionnaireRespiratory function030212 general & internal medicineProspective StudiesProspective cohort studyLungDepression (differential diagnoses)COPDDepressionMiddle AgedCircadian RhythmPhenotypeItalyAnxietyFemalemedicine.symptom24-hour symptoms Clinical phenotype Real-world Respiratory functionResearch ArticleHumanPulmonary and Respiratory Medicinemedicine.medical_specialtyChronic ObstructiveTime FactorSettore MED/10 - Malattie Dell'Apparato RespiratorioPulmonary Disease03 medical and health sciencesInternal medicineHumansAsthma24-hour symptoms; Clinical phenotype; Real-world; Respiratory function; Aged; Anxiety; Depression; Female; Forced Expiratory Volume; Health Status; Humans; Italy; Lung; Male; Middle Aged; Phenotype; Prospective Studies; Pulmonary Disease Chronic Obstructive; Severity of Illness Index; Sleep; Surveys and Questionnaires; Time Factors; Circadian Rhythm; Quality of LifeAgedlcsh:RC705-77924-hour symptomsbusiness.industryCorrectionlcsh:Diseases of the respiratory systemmedicine.disease24-hour symptomProspective Studie030228 respiratory systemReal-worldQuality of LifebusinessSleepRespiratory function
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Disease awareness in patients with COPD: measurement and extent

2018

Ilaria Baiardini,1 Paola Rogliani,2 Pierachille Santus,3 Angelo G Corsico,4 Marco Contoli,5 Nicola Scichilone,6 Fabiano Di Marco,7 Patrizia Lessi,8 Carla Scognamillo,8 Giorgia Molinengo,9 Fabio Ferri,10 Vincenzo Patella,11 Giuseppe Fiorentino,12 Mauro Carone,13 Fulvio Braido14 1Department of Biomedical Sciences, Humanitas University, Milan, Italy; 2Respiratory Unit, Department of Experimental Medicine, University of Rome “Tor Vergata”, Rome, Italy; 3Department of Biomedical and Clinical Sciences (DIBIC), University of Milan, Milan, Italy; 4Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy; 5Department of Medical Sciences, University of F…

MaleHealth Knowledge Attitudes PracticeTime Factorspatient satisfactionSettore MED/10 - Malattie dell'Apparato RespiratorioDiseaseSeverity of Illness IndexPulmonary Disease Chronic Obstructive0302 clinical medicineCost of IllnessSurveys and QuestionnairesActivities of Daily Living80 and overawareness030212 general & internal medicineLungIllness BehaviorAged 80 and overPracticeCOPDHealth PolicyHealth KnowledgeGeneral MedicineMiddle AgedItalyFemalePublic HealthPulmonary and Respiratory MedicineChronic Obstructivemedicine.medical_specialtySocio-culturaleInternational Journal of Chronic Obstructive Pulmonary DiseasePulmonary DiseaseTreatment satisfactionIllness perceptions03 medical and health sciencesNegatively associatedAwareness; COPD; Patient satisfaction; Questionnaire; Activities of Daily Living; Aged; Aged 80 and over; Cost of Illness; Dyspnea; Female; Humans; Illness Behavior; Italy; Lung; Male; Middle Aged; Patient Compliance; Patient Satisfaction; Pulmonary Disease Chronic Obstructive; Reproducibility of Results; Severity of Illness Index; Surveys and Questionnaires; Time Factors; Awareness; Health Knowledge Attitudes Practice; Patient Acceptance of Health CaremedicineHumansCOPDIn patientAgedlcsh:RC705-779business.industryquestionnaireEnvironmental and Occupational HealthPublic Health Environmental and Occupational HealthAwareneReproducibility of Resultslcsh:Diseases of the respiratory systemPatient Acceptance of Health Caremedicine.diseaseCOPD; awareness; patient satisfaction; questionnaireawareness; COPD; patient satisfaction; questionnaire; Pulmonary and Respiratory Medicine; Health Policy; Public Health Environmental and Occupational HealthClinical trialDyspnea030228 respiratory systemClinical Trial ReportAttitudesPhysical therapyPatient CompliancePatient awarenessbusiness
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Gastritis and gastroesophageal reflux disease are strongly associated with non-allergic nasal disorders

2021

AbstractBackgroundGastroesophageal reflux disease (GERD) has been reported to be significantly associated with chronic rhinosinusitis, but the strength of the association is still debated.AimsTo evaluate the strength of the association between gastritis/GERD and non-allergic rhinitis (NAR)/allergic rhinitis (AR)/sinusitis.MethodsWe investigated 2887 subjects aged 20–84 years, who underwent a clinical visit in seven Italian centres (Ancona, Palermo, Pavia, Terni, Sassari, Torino, Verona) within the study on Gene Environment Interactions in Respiratory Diseases, a population-based multicase-control study between 2008 and 2014. Subjects were asked if they had doctor-diagnosed “gastritis or sto…

MaleNon-allergic rhinitisGastroesophageal reflux diseaseGastroenterologyAllergic rhinitis0302 clinical medicinePrevalenceNon-allergic rhiniti030223 otorhinolaryngologySinusitisRhinitisAged 80 and overeducation.field_of_studyMiddle AgedGastrititItalyGastritisGastroesophageal RefluxFemalePublic HealthGastritismedicine.symptomResearch ArticleAdultPulmonary and Respiratory Medicinemedicine.medical_specialtyPopulationGastrititsSettore MED/10 - Malattie Dell'Apparato RespiratorioNOHiatal herniaGastritits Gastroesophageal refux disease Allergic rhinitis Non-allergic rhinitis SinusitisYoung Adult03 medical and health sciencesAllergic rhinitis; Gastritits; Gastroesophageal reflux disease; Non-allergic rhinitis; SinusitisInternal medicineAllergic rhinitimedicineHumansGastroesophageal refux diseaseSinusitiseducationAgedlcsh:RC705-779business.industrylcsh:Diseases of the respiratory systemmedicine.diseaseRhinitis AllergicSinusitidigestive system diseases030228 respiratory systemRelative riskChronic DiseaseGERDAllergic rhinitis; Gastritits; Gastroesophageal reflux disease; Non-allergic rhinitis; Sinusitis Public HealthNon-allergic rhinitisbusinessEsophagitis
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Discriminative and predictive properties of disease-specific and generic health status indexes in elderly COPD patients

2008

Abstract Background The association between bronchial obstruction severity and mortality in Chronic Obstructive Pulmonary Disease (COPD) is well established, but it is unknown whether disease-specific health status measures and multidimensional assessment (MDA) have comparable prognostic value. Methods We analyzed data coming from the Salute Respiratoria nell'Anziano (Respiratory Health in the Elderly – SaRA) study, enrolling elderly people attending outpatient clinics for respiratory and non-respiratory problems. From this population we selected 449 patients with bronchial obstruction (77.3% men, mean age 73.1). We classified patients' health status using tertiles of the Saint George Respi…

MalePulmonary and Respiratory MedicineDisease specificmedicine.medical_specialtyCopd patientsPulmonary diseaseSettore MED/10 - Malattie Dell'Apparato RespiratorioSeverity of Illness IndexPulmonary Disease Chronic ObstructiveDiscriminative modelForced Expiratory VolumeSeverity of illnessmedicineHealth Status IndicatorsHumansCOPDIntensive care medicineSurvival analysisAgedlcsh:RC705-779COPDbusiness.industrylcsh:Diseases of the respiratory systemPrognosismedicine.diseaseSurvival AnalysisFemaleGeriatric Depression ScalebusinessResearch Article
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Patterns and predictors of low physical activity in patients with stable COPD: a longitudinal study

2020

Background: Despite the frequency and negative impact of low physical activity among patients with chronic obstructive pulmonary disease (COPD), little is known about how it persists and remits over time or the factors predicting new states of low physical activity. The aim of the study was to determine the probability of a transition between states of low and nonlow physical activity in a cohort of patients with stable COPD followed for 2 years. We also investigated different potentially modifiable factors to determine whether they can predict new states of low physical activity. Methods: We prospectively included 137 patients with stable COPD (mean age 66.9 ± 8.3 years). Physical activity…

MalePulmonary and Respiratory MedicineLongitudinal studymedicine.medical_specialtyTime FactorsHealth StatusPhysical activityphysical activityPulmonary diseasePulmonary Disease Chronic Obstructive03 medical and health sciences0302 clinical medicineRisk FactorsInternal medicineCOPDHumansMedicinePharmacology (medical)In patientLongitudinal StudiesProspective Studies030212 general & internal medicineExerciseLungOriginal ResearchAgedlcsh:RC705-779COPDbusiness.industrytransitionlcsh:Diseases of the respiratory systemdyspneaMiddle AgedPrognosismedicine.disease5STS030228 respiratory systemDisease ProgressionFemaleSedentary BehaviorbusinessTherapeutic Advances in Respiratory Disease
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Nerve ablation after bronchial thermoplasty and sustained improvement in severe asthma

2017

Abstract Background Bronchial thermoplasty (BT) is a non-pharmacological intervention for severe asthma whose mechanism of action is not completely explained by a reduction of airway smooth muscle (ASM). In this study we analyzed the effect of BT on nerve fibers and inflammatory components in the bronchial mucosa at 1 year. Methods Endobronchial biopsies were obtained from 12 subjects (mean age 47 ± 11.3 years, 50% male) with severe asthma. Biopsies were performed at baseline (T0) and after 1 (T1), 2 (T2) and 12 (T12) months post-BT, and studied with immunocytochemistry and microscopy methods. Clinical data including Asthma Quality of Life Questionnaire (AQLQ) and Asthma Control Questionnai…

MaleSevere asthmaBronchial biopsieBiopsymedicine.medical_treatmentVital CapacityGastroenterologyBronchial thermoplasty0302 clinical medicineBronchoscopyQuality of lifeForced Expiratory VolumeSubmucosa030212 general & internal medicinemedicine.diagnostic_testCD68Middle AgedNerve fiberAblationImmunohistochemistryResidual VolumeTreatment Outcomemedicine.anatomical_structureAsthma Control QuestionnaireFemaleResearch ArticleAdultPulmonary and Respiratory Medicinemedicine.medical_specialtyBronchiBronchial biopsiesNerve fibersRespiratory MucosaSettore MED/10 - Malattie Dell'Apparato Respiratorio03 medical and health sciencesInternal medicineBronchoscopymedicineHumansAgedAsthmalcsh:RC705-779Bronchial thermoplastybusiness.industryTotal Lung Capacitylcsh:Diseases of the respiratory systemmedicine.diseaseAsthmarespiratory tract diseases030228 respiratory systembusinessBMC Pulmonary Medicine
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Authors’ response

2012

Claudio Sorino,1,2 Salvatore Battaglia,1 Nicola Scichilone,1 Claudio Pedone,3 Raffaele Antonelli-Incalzi,3 Duane Sherrill,4 Vincenzo Bellia11Biomedical Department of Internal and Specialist Medicine, Section of Pulmonology, University of Palermo, Italy; 2Division of Pulmonology, S Anna Hospital, Como, Italy; 3Chair of Geriatrics, University Campus Bio-Medico, Roma, Italy; 4Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USABackground: The choice between lower limit of normal or fixed value of forced expiratory volume in one second/forced vital capacity ratio (FEV1/FVC) < 0.70 as the criterion for confirming airway obstruction is an open issue. In t…

MaleSpirometryVital capacitymedicine.medical_specialtyLetterCross-sectional studyVital CapacityInternational Journal of Chronic Obstructive Pulmonary DiseaseSettore MED/10 - Malattie Dell'Apparato RespiratorioPulmonary function testingPulmonary Disease Chronic ObstructiveFEV1/FVC ratioForced Expiratory VolumeInternal medicinemedicineHumansAgedAged 80 and overlcsh:RC705-779COPDmedicine.diagnostic_testbusiness.industryGeneral MedicineHealthy elderlylcsh:Diseases of the respiratory systemAirway obstructionrespiratory systemmedicine.diseaselung function test elderlyRespiratory Function TestsSurgeryrespiratory tract diseasesCross-Sectional StudiesItalyCardiologyFemalebusinesscirculatory and respiratory physiologyInternational Journal of COPD
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Bacterial load and inflammatory response in sputum of alpha-1 antitrypsin deficiency patients with COPD

2019

Bruno Balbi,1 Claudia Sangiorgi,1 Isabella Gnemmi,1 Ilaria Ferrarotti,2 Davide Vallese,1 Elena Paracchini,1 Lorena Delle Donne,1 Luciano Corda,3 Paolo Baderna,4 Angelo Corsico,2 Mauro Carone,1 Paola Brun,5 Francesco Cappello,6,7 Fabio LM Ricciardolo,8 Paolo Ruggeri,9 Sharon Mumby,10 Ian M Adcock,10 Gaetano Caramori,9 Antonino Di Stefano11Istituti Clinici Scientifici Maugeri, IRCCS, Division of Pneumology and Laboratory of Cytoimmunopathology of the Heart and Lung, Veruno, Italy; 2Department of Internal Medicine and Medical Therapy, University of Pavia, Pavia, Italy; 3Medicina Respiratoria, Seconda Medicina Interna, Spedali Civili, Brescia, Italy; 4Division of Pneumology, Aosta Hospital, Aos…

Malealpha-1 antitrypsin deficiency COPD chronic inflammationchronic inflammationINTERLEUKIN-27AIRWAY INFLAMMATIONRespiratory SystemInternational Journal of Chronic Obstructive Pulmonary DiseaseFREQUENCYACTIVATIONPulmonary Disease Chronic ObstructiveRisk Factorsalpha 1-Antitrypsin DeficiencyHumansCOPD1102 Cardiorespiratory Medicine and HaematologyLungNEUTROPHILSAgedOriginal Researchlcsh:RC705-779Science & TechnologyBacteriaSmokingsputumrespiratory disabilitylcsh:Diseases of the respiratory systemMiddle AgedMICROBIOTABacterial Loadrespiratory tract diseaseschronic airway inflammationCHRONIC-BRONCHITISalpha-1 antitrypsin deficiencyCase-Control StudiesAlpha-1 antitrypsin deficiencyHost-Pathogen InteractionsAUGMENTATION THERAPYFemaleInflammation MediatorsLife Sciences & BiomedicineAlpha-1 antitrypsin deficiency; Chronic airway inflammation; COPD; Respiratory disability; SputumInternational Journal of COPD
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GOLD and the fixed ratio

2012

We thank Dr Vestbo for his interest in our manuscript “Diagnosis of airway obstruction in the elderly: contribution of the SARA study” and for the opportunity to clarify some points. As mentioned in the title and aims, the intent of the paper is to offer a contribution to the open issue of identification of airway obstruction in elderly people.1 We agree with Dr Vestbo about the utility of distinguishing between the clinical and functional aspects of chronic obstructive pulmonary disease (COPD). We stress that, until the term COPD is used, diagnosis needs clinical evidence of a chronic pulmonary disease and functional evidence of airway obstruction. Given that symptoms compatible with COPD …

Malemedicine.medical_specialtyPopulationspirometryDiseaseInternational Journal of Chronic Obstructive Pulmonary Diseaseairflow obstructionchronic obstructive pulmonary diseaseFEV1/FVC ratioPulmonary Disease Chronic ObstructiveEpidemiologymedicineHumansOverdiagnosisMedical prescriptionIntensive care medicineeducationOriginal Researchlcsh:RC705-779COPDeducation.field_of_studybusiness.industryagingGeneral Medicinelung function testslcsh:Diseases of the respiratory systemAirway obstructionrespiratory systemmedicine.diseaseforced expiratory volumerespiratory tract diseasesPhysical therapyFemalebusinesscirculatory and respiratory physiologyInternational Journal of COPD
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