Search results for "RCA"
showing 10 items of 3171 documents
Identificación de biomarcadores circulantes con valor pronóstico y predictivo de respuesta en cáncer de mama triple negativo
2019
Introducción: El cáncer de mama triple negativo se caracteriza porque las pacientes que alcanzan una respuesta patológica completa a la quimioterapia neoadyuvante presentan mejor pronóstico. Sin embargo, las pacientes refractarias o pobremente respondedoras a la quimioterapia neoadyuvante presentan una peor supervivencia. Todo ello hace que sea de vital importancia la identificación temprana de estas pacientes, para tratar de alterar la secuencia de tratamiento pasando inicialmente a cirugía o valorar otras alternativas terapéuticas. Diseño: En el trabajo se ha combinado la metabolómica, los miARNs en exosomas circulantes y la citometría de flujo como aproximaciones experimentales para el e…
Estrategias para el análisis de datos metabolómicos dirigidos al diagnóstico clínico
2018
La metabolómica es un área de investigación emergente y puede ser considerada, a nivel bioquímico, como el final de la cascada “ómica” (genómica → transcriptómica →proteómica → metabolómica) ya que los cambios en el metaboloma constituyen la última respuesta del organismo a alteraciones genéticas, químicas, ambientales, etc. En ese sentido, el metaboloma está muy ligado al fenotipo y puede constituir una herramienta sumamente útil para diagnosticar enfermedades y evaluar el efecto de los tratamientos. Los metabolitos son los productos finales de todos los procesos que se producen en las células, y las concentraciones de metabolitos en los procesos patológicos reflejan la adaptación de los s…
La religión del cuerpo-mercancía: ¿un nuevo opio del pueblo?
2018
The commercial exploitation or more precisely the total capitalist management of the human body erects this as a universal divinity. The direct consequence of this generalized corporal capitalism is the massive depoliticization of the body and, often, the reflection that is dedicated to it. In this article, we seek to reflect on the current practices of bodily modifications within the framework of the changes in the regimes of neoliberal governance in recent decades. This reflection is guided by the revision of central texts of critical theory
Molecular screening of the BRCA1/2 genes and clinical significance of unknown sequence variants in families with hereditary breast/ovarian cancer
2012
Novel anti-obesity drugs and plasma lipids
2014
Obesity is a health problem of global, epidemic proportions and a major risk factor for chronic diseases resulting in accelerated morbidity and mortality. Dyslipidemia with a predominance of small dense LDL, impaired functionality of HDL particles, and increased serum levels of remnant particles due to impaired clearance of triglyceriderich lipoproteins significantly heightens cardiovascular events in obese subjects. Pharmacotherapy in combination with lifestyle modification is the primary approach to reduce obesity-related cardiovascular risk. Although there are several potential anti-obesity drugs, orlistat is the only agent that remains available in the market. Lorcaserin and Qsymia ® , …
Blood CO2 and pH Transients During Apnoea after O2 Breathing in Patients
1990
Endotracheal intubation always is combined with an apnoea the duration of which is dependent on the technique used, the skills of the intubator, and the anatomical situation. The resulting typical potential risks may be (among others) both hypoxaemia and hypercapnia. Therefore the tolerable apnoea time for an intubation procedure is limited in clinical practice to 1 – 2 minutes. It must be noted that the developing hypercapnia is inevitable, whereas hypoxaemia may be avoided even in prolonged apnoea (e.g. >2 min) with “adaequate” preoxygenation [Duda et al., 1988]. Using de-nitrogenation techniques (breathing pure oxygen for 30 to 60 min) “anaesthetized and curarized normal subjects tolerat…
Negative online reviews and webcare strategies in social media: effects on hotel attitude and booking intentions
2018
The purpose of this research is to examine the effects of different webcare strategies (defensive, accommodative, no action) across two different types of social media (TripAdvisor and Twitter) on hotel attitude and booking intentions. The results of an experimental design show that negative electronic word-of-mouth (NWOM) has a negative effect on attitudes and booking intention. Moreover, the benefits derived from the type of response vary depending on the social media type in which NWOM appears. The findings also suggest that no response is worse than either defensive or accommodative responses.
Ligand-Length Modification in CsPbBr3 Perovskite Nanocrystals and Bilayers with PbS Quantum Dots for Improved Photodetection Performance
2020
Nanocrystals surface chemistry engineering offers a direct approach to tune charge carrier dynamics in nanocrystals-based photodetectors. For this purpose, we have investigated the effects of altering the surface chemistry of thin films of CsPbBr3 perovskite nanocrystals produced by the doctor blading technique, via solid state ligand-exchange using 3-mercaptopropionic acid (MPA). The electrical and electro-optical properties of photovoltaic and photoconductor devices were improved after the MPA ligand exchange, mainly because of a mobility increase up to 5 ×
El uso obligatorio de la marca registrada (nacional y comunitaria)
1997
La obra estudia en detalle uno de los pilares fundamentales del Derecho de marcas, el uso obligatorio de la misma como requisito para conservar este derecho de duración eventualmente ilimitada. El estudio de este instituto se analiza desde el sistema español, desglosando su contenido y analizando su materialización por parte de los titulares de marcas nacionales, si bien, la convivencia de estos signos con los comunitarios, obliga a tratar aquellos aspectos del sistema comunitario con los que el titular de una marca nacional tiene que enfrentarse cuando su signo entra en conflicto con otro comunitario. Se critica, además, la falta de virtualidad de la figura desde su actual configuración en…
Recensione al libro di Marcella Marmo, Il coltello e il mercato. La camorra prima e dopo l’Unità d’Italia, Napoli-Roma, l’Ancora del Mediterraneo, 20…
2012
Il saggio recensisce il volume di Marcella Marmo nel quale l'autrice conduce il lettore all’interno del suo testo, mettendo in chiaro – quasi a voler stipulare un accordo con l’interlocutore – uno stile, un metodo di ricerca. Ricerca storica, come l’autrice tiene a precisare formulando le sue critiche nei confronti di una certa sociologia – la sociologia economica di stampo funzionalista – accusata di eccessivo riduzionismo nella lettura del fenomeno criminale mafioso, appiattito sulla dimensione d’impresa, costretto entro le coppie fiducia/sfiducia, protezione/estorsione, tradizione/modernità. Approccio storico, dunque, laddove la storia è intesa come “disciplina del contesto”, attenta all…