Search results for "RCA"
showing 10 items of 3171 documents
TRADITION AND MODERNITY OF CATALAN VAULTS: HISTORICAL AND STRUCTURAL ANALYSIS
2012
Il lavoro analizza da diversi punti di vista un particolare tipo di strutture voltate noto come volte catalane (bóveda tabicada) e la tecnica costruttiva correlata. Le volte catalane sono volte realizzate da strati alterni di mattoni e malta, caratterizzate da un esiguo spessore in relazione alle altre dimensioni. Il primo passo presentato nel lavoro è quello di investigare tutti gli aspetti storici al fine di inquadrare sia la tipologia che la tecnica costruttiva correlata all'interno della storia dell'architettura e di individuare le ragioni di un così grande successo lungo i secoli. Successivamente, è stata effettuata una campagna di indagini sperimentali, che completa una precedente, su…
IPERCALCEMIA
2010
The Lipid-Sensor Candidates CD36 and GPR120 Are Differentially Regulated by Dietary Lipids in Mouse Taste Buds: Impact on Spontaneous Fat Preference
2011
BACKGROUND: Recent studies in rodents and humans suggest that the chemoreception of long-chain fatty acids (LCFA) in oral cavity is involved in the spontaneous preference for fatty foods and might contribute to the obesity risk. CD36 and GPR120 are LCFA receptors identified in rodent taste bud cells. The fact that CD36 or GPR120 gene inactivation leads to a decrease in the preference for lipids raises the question of the respective role(s) played by these gustatory lipid-sensor candidates. METHODOLOGY/PRINCIPAL FINDINGS: Using a combination of biochemical, nutritional and behavioural studies in wild-type, CD36(+/-)and CD36(-/-) mice, it was found that: 1°) CD36 and GPR120 display different …
Alcune osservazioni sugli Enti (pubblici) di ricerca: il loro ruolo e brevi cronache di una devastazione annunciata.
2011
Verranno presentate alcune considerazioni sul ruolo che gli Enti di ricerca dovrebbero (e potrebbero) svolgere nel complesso sistema dell’alta formazione e di quello che ad essa è connesso (dallo sviluppo produttivo al vivere civile). La motivazione di fondo, poi, delle considerazioni che seguono è che la ricerca scientifica può svolgere un ruolo cruciale in tutti questi aspetti in quanto essa è connessa in modo essenziale all’uso di un metodo critico che fa discendere le conclusioni cui essa arriva dalle argomentazioni addotte e non dall’autorità di qualcuno.
Tracking Ca2+ ATPase intermediates in real time by x-ray solution scattering
2020
Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) transporters regulate calcium signaling by active calcium ion reuptake to internal stores. Structural transitions associated with transport have been characterized by x-ray crystallography, but critical intermediates involved in the accessibility switch across the membrane are missing. We combined time-resolved x-ray solution scattering (TR-XSS) experiments and molecular dynamics (MD) simulations for real-time tracking of concerted SERCA reaction cycle dynamics in the native membrane. The equilibrium [Ca2] E1 state before laser activation differed in the domain arrangement compared with crystal structures, and following laser-induced release o…
Measurement of brain tissue pressure in cold induced cerebral oedema.
1973
Experiments were performed in order to evaluate the concept that brain oedema is associated with an increase in local interstitial fluid pressure. Assuming that the pressure measured by the cotton wick technique represents the hydrostatic interstitial fluid pressure, the tissue pressure was recorded with pressure transducers in the white matter adjacent and remote to a local cold injury, in the opposite hemisphere, and in the cisterna magna. In 9 cats during steady-state conditions mean tissue pressures between 1.20±0.30 mm Hg and 2.33±0.80 mm Hg were found, as compared to a mean CSF pressure of 5.17±0.82 mm Hg. The tissue pressure was found to increase significantly adjacent to the lesion …
Búsqueda de nuevos ingredientes bioactivos en obesidad para el diseño de nuevos alimentos funcionales, en base a la demanda del consumidor
2015
La innovación tecnológica en materia de salud ha sido un campo ampliamente estudiado y sigue siendo un foco de interés económico reiterado y prioritario. La alimentación es uno de los hábitos que más repercusión tienen en el estado de salud y en la prevención de determinadas enfermedades lo que influye cada vez más en los hábitos de compra de los consumidores (Niva M., 2007, Bech-Larsen T et al., 2007, Jones PJ et al., 2007, Van Kleef E et al., 2002). Un trastorno de la alimentación puede generar obesidad y con ello el desarrollo de múltiples complicaciones asociadas a la misma. En los últimos años, la Organización Mundial de la Salud (WHO., 2014 y 2015) ha venido alertando de la gran crisi…
Dissimilar PTH, Gastrin, and Calcitonin Responses to Oral Calcium and Peptones in Hypocalciuric Hypercalcemia, Primary Hyperparathyroidism, and Norma…
2005
We analyzed gastrin, PTH, and calcitonin responses to oral calcium and peptones in hypocalciuric hypercalcemia, mild primary hyperparathyroidism, and normal controls. We observed diverse hormonal responses that may help in the differential diagnosis of these conditions. Introduction: Hypocalciuric hypercalcemia (HH) is consequent to calcium-sensing receptor (CaSR) genetic mutations or anti-CaSR antibodies. CaSR is expressed in parathyroid tissue, thyroid C cells, and gastrin-secreting cells, where it has been suggested that on calcium and/or amino acid allosteric activation, promotes gastrin secretion. Materials and Methods: We evaluated gastrin, PTH, and calcitonin responses to oral calciu…
Increased Gastrin and Calcitonin Secretion after Oral Calcium or Peptones Administration in Patients with Hypercalciuria: A Clue to an Alteration in …
2005
The calcium-sensing receptor (CaSR) has been detected in human antral gastrin-secreting cells, where, upon calcium and/or amino acid allosteric activation, it stimulates gastrin secretion. Patients with absorptive hypercalciuria (AH) display an enhanced gastric acid output; therefore, we evaluated the secretion of gastrin in subjects with AH ( 30 subjects vs. 30 healthy female controls, all postmenopausal) after oral calcium administration ( 1 g calcium gluconate) and, on a separate occasion, after peptone loading test ( protein hydrolyzed, 10 g). Gastrin and monomeric calcitonin responses were higher in AH after both oral calcium administration ( P < 0.01) and peptone loading ( P< 0.01). B…
2020
Endoplasmic reticulum (ER) calcium homeostasis plays an essential role in cellular calcium signaling, intra-ER protein chaperoning and maturation, as well as in the interaction of the ER with other organelles. Calcium is accumulated in the ER by sarco/endoplasmic reticulum calcium ATPases (SERCA enzymes) that generate by active, ATP-dependent transport, a several thousand-fold calcium ion concentration gradient between the cytosol (low nanomolar) and the ER lumen (high micromolar). SERCA enzymes are coded by three genes that by alternative splicing give rise to several isoforms, which can display isoform-specific calcium transport characteristics. SERCA expression levels and isoenzyme compo…