Search results for "RCI"
showing 10 items of 16009 documents
Effects of eight weeks of physical training on physical performance and heart rate variability in children
2017
Study aim: Physically active adults have been shown to have higher heart rate variability (HRV) than less active adults, but less is known about children in this regard. In adults, training-induced changes in physical performance have been shown to be related to increase in HRV, especially in its high frequency component (HF), which is a marker of parasympathetic activity. The purpose of this study was to examine whether 8 weeks of instructed physical training would improve physical performance and cardiac autonomic function (HRV) in secondary school pupils and to examine the relationship between changes in physical performance and the function of the autonomic nervous system. Material and …
Czy gęsi są głupie? O ptasiej filozofii Mikołaja Reja słów kilka
2017
The article is an attempt to solve the enigma on the potential advantages of the Polish language that comes from the line to the person who will read from Zwierzyniec Mikołaj Rej. The author reviews the most famous and popular meanings of the symbols geese from antiquity to the Renaissance times. Indicated is a long road traveled by this positively associated theme until symbol geese has become synonymous mindless chatter. The opposite of the “idle talk” is the work of Miko³aj Rej, who was the father of Polish literature, hoisted our national culture to new heights.
Crowdsourcing as a mode of open innovation: Exploring drivers of success of a multisided platform through system dynamics modelling
2020
This article aims to explore drivers of success of a crowdsourcing platform. The study conceptualizes crowdsourcing as a mode of open innovation and places such a concept within the context of the sharing economy. Upon this framework, the paper analyses the case of InnoCentive, a successful crowdsourcing platform where innovation-driven organizations search for solutions to their R&D tasks. The system dynamics model frames main InnoCentive business processes and offers a causal perspective on the relationships between platform performance—in terms of users base—and resources structure. The discussion on simulation outputs is carried out through a dynamic performance management view of p…
Six-Week Endurance Exercise Alters Gut Metagenome That Is not Reflected in Systemic Metabolism in Over-weight Women.
2018
Recent studies suggest that exercise alters the gut microbiome. We determined whether six-weeks endurance exercise, without changing diet, affected the gut metagenome and systemic metabolites of overweight women. Previously sedentary overweight women (n = 19) underwent a six-weeks endurance exercise intervention, but two were excluded due to antibiotic therapy. The gut microbiota composition and functions were analyzed by 16S rRNA gene amplicon sequencing and metagenomics. Body composition was analyzed with DXA X-ray densitometer and serum metabolomics with NMR metabolomics. Total energy and energy-yielding nutrient intakes were analyzed from food records using Micro-Nutrica software. Serum…
Six-Week Endurance Exercise Alters Gut Metagenome That Is not Reflected in Systemic Metabolism in Over-weight Women
2018
Recent studies suggest that exercise alters the gut microbiome. We determined whether six-weeks endurance exercise, without changing diet, affected the gut metagenome and systemic metabolites of overweight women. Previously sedentary overweight women (n = 19) underwent a six-weeks endurance exercise intervention, but two were excluded due to antibiotic therapy. The gut microbiota composition and functions were analyzed by 16S rRNA gene amplicon sequencing and metagenomics. Body composition was analyzed with DXA X-ray densitometer and serum metabolomics with NMR metabolomics. Total energy and energy-yielding nutrient intakes were analyzed from food records using Micro-Nutrica software. Serum…
Dexamethasone premedication suppresses vaccine-induced immune responses against cancer
2020
ABSTRACT Glucocorticosteroids (GCS) have an established role in oncology and are administered to cancer patients in routine clinical care and in drug development trials as co-medication. Given their strong immune-suppressive activity, GCS may interfere with immune-oncology drugs. We are developing a therapeutic cancer vaccine, which is based on a liposomal formulation of tumor-antigen encoding RNA (RNA-LPX) and induces a strong T-cell response both in mice as well as in humans. In this study, we investigated in vivo in mice and in human PBMCs the effect of the commonly used long-acting GCS Dexamethasone (Dexa) on the efficacy of this vaccine format, with a particular focus on antigen-specif…
E-NAUTILUS: A decision support system for complex multiobjective optimization problems based on the NAUTILUS method
2015
Interactive multiobjective optimization methods cannot necessarily be easily used when (industrial) multiobjective optimization problems are involved. There are at least two important factors to be considered with any interactive method: computationally expensive functions and aspects of human behavior. In this paper, we propose a method based on the existing NAUTILUS method and call it the Enhanced NAUTILUS (E-NAUTILUS) method. This method borrows the motivation of NAUTILUS along with the human aspects related to avoiding trading-off and anchoring bias and extends its applicability for computationally expensive multiobjective optimization problems. In the E-NAUTILUS method, a set of Pareto…
Role of Acquisition Intervals in Private and Public Cloud Storage Costs
2014
The volume of worldwide digital content has increased nine-fold within the last five years, and this immense growth is predicted to continue in the foreseeable future to reach 8 ZB by 2015. Traditionally, organizations proactively have built and managed their private storage facilities to cope with the growing demand for storage capacity. Recently, many organizations have instead welcomed the alternative of outsourcing their storage needs to the providers of public cloud storage services due to the proliferation of public cloud infrastructure offerings. The comparative cost-efficiency of these two alternatives depends on a number of factors, such as the prices of the public and private stor…
Best Practices for International eSourcing of Software Products and Services from the Service Providers' Perspective
2015
This research analyzes how eSourcing service providers can execute the Information and Communications Technology-enabled international sourcing of software-intensive systems and services (eSourcing) effectively. The extant literature falls short of providing a detailed enough set of best practices and supporting classes of information systems to help providers to manage and deliver effective services. This research presents a set of best practices for international eSourcing service providers to facilitate the execution, improvement, and management of international eSourcing services. The practices help providers to establish and execute a mature eSourcing life-cycle in order to overcome th…
An Information Systems Design Product Theory for Integrated Requirements, Test and Defect Management Systems
2012
Software companies need to develop high-quality products fast and with low cost. Development activities are typically distributed in different places and involve multiple stakeholders in different countries. Testing is an important way to ensure product quality but it is costly and takes ample time and resources. Sourcing testing services from specialized service providers is often the most viable option for software businesses. Flexible and effective test process management is especially vital to support the testing life-cycle when external testing service providers are involved. Yet, the extant literature provides little theoretical guidance for managing the testing life-cycle, including …