Search results for "RED"
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Debitoru parādu uzskaite un pārvaldība SIA "ABC"
2020
Diplomdarba “Debitoru parādu uzskaite un pārvaldība SIA “ABC”” aktualitāte ir pamatota ar to, ka efektīva debitoru parādu uzskaites un pārvaldības sistēma ir svarīgs priekšnosacījums veiksmīgai uzņēmējdarbības attīstībai. Darba mērķis ir, pamatojoties uz normatīvā regulējuma un vispārpieņemto teorētisko principu prasību izpēti, novērtēt SIA “ABC” debitoru parādu uzskaiti un pārvaldību un izstrādāt priekšlikumus konstatēto trūkumu novēršanai un debitoru parādu uzskaites un pārvaldības procesa pilnveidošanai. Pētījuma rezultātā tika konstatēti trūkumi uzņēmuma SIA “ABC” debitoru parādu uzskaitē un pārvaldībā un sniegti priekšlikumi to novēršanai.
EPIDEMIOLOĢISKO PĒTĪJUMU DIZAINI
2021
Bakalaura darbs ir veltīts epidemioloģijas pētījumu dizainiem. Šādi pētījumi parasti sastopami medicīnā, bioloģijā, sabiedrības veselības zinātnē u.c. nozarēs. Darbā aprakstīts pētījumu dizainu iedalījums atkarībā no tā, vai tie ir novērojumu vai eksperimentālie pētījumi, kuri, savukārt, attiecīgi iedalās apakšdizainos, piemēram, novērojošie pētījumi iedalās gadījuma-kontroles, kohortas un šķērsgriezuma pētījumos, bet eksperimentālo pētījumu dizaini ietver kvazi-eksperimentus un randomizētus kontrolētus pētījumus. Katram dizainam tiek sniegts galveno priekšrocību un trūkumu apraksts, kā arī norādīti atbilstoši statistiskie aprēķini. Sniegtas arī galvenās epidemioloģijas zinātnes pamatjēdzie…
HEALTHCARE QUALITY - A MANAGERIAL APPROACH
2014
Healthcare quality has been defined in different ways, depending on the dimension that the authors had in mind. Furthermore, if initially healthcare quality was defined and assessed from the specialists’ and researchers’ point of view, nowadays the importance of patient and the public opinion preferences and perspective has been recognized. Thus, the first step in assessing the quality of these services involves defining what is meant by "quality". Along these lines, this paper presents the results of a qualitative research, conducted on a sample of 16 managers, quality managers and CEOs of several clinics and hospitals, both public and private (for-profit), from Bucharest.
1,2,4-OSSADIAZOLI: UTILI SCAFFOLD NEL DESIGN DI NUOVI FARMACI
2021
Redox reaction between amino‐(3,4‐dihydroxyphenyl)methyl phosphonic acid and dopaquinone is responsible for the apparent inhibitory effect on tyrosin…
2002
Amino‐(3,4‐dihydroxyphenyl)methyl phosphonic acid, the phosphonic analog of 3,4‐dihydroxyphenylglycine, had been previously reported as a potent inhibitor of tyrosinase. The mechanism of the apparent enzyme inhibition by this compound has now been established. Amino‐(3,4‐dihydroxyphenyl)methyl phosphonic acid turned out to be a substrate and was oxidized to o‐quinone, which evolved to a final product identified as 3,4‐dihydroxybenzaldehyde, the same as for 3,4‐dihydroxyphenylglycine. Monohydroxylated compounds (amino‐(3‐hydroxyphenyl)methyl phosphonic acid and amino‐(4‐hydroxyphenyl)methyl phosphonic acid) were not oxidized, neither was 4‐hydroxy‐l‐phenylglycine. However, the relatively hig…
Rac1-Regulated Endothelial Radiation Response Stimulates Extravasation and Metastasis That Can Be Blocked by HMG-CoA Reductase Inhibitors
2011
Radiotherapy (RT) plays a key role in cancer treatment. Although the benefit of ionizing radiation (IR) is well established, some findings raise the possibility that irradiation of the primary tumor not only triggers a killing response but also increases the metastatic potential of surviving tumor cells. Here we addressed the question of whether irradiation of normal cells outside of the primary tumor augments metastasis by stimulating the extravasation of circulating tumor cells. We show that IR exposure of human endothelial cells (EC), tumor cells (TC) or both increases TC-EC adhesion in vitro. IR-stimulated TC-EC adhesion was blocked by the HMG-CoA reductase inhibitor lovastatin. Glycyrr…
Aplidin® induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 ph…
2006
Aplidin® is an antitumor agent in phase II clinical trials that induces apoptosis through the sustained activation of Jun N-terminal kinase (JNK). We report that Aplidin® alters glutathione homeostasis increasing the ratio of oxidized to reduced forms (GSSG/GSH). Aplidin® generates reactive oxygen species and disrupts the mitochondrial membrane potential. Exogenous GSH inhibits these effects and also JNK activation and cell death. We found two mechanisms by which Aplidin® activates JNK: rapid activation of Rac1 small GTPase and downregulation of MKP-1 phosphatase. Rac1 activation was diminished by GSH and enhanced by L-buthionine (SR)-sulfoximine, which inhibits GSH synthesis. Downregulatio…
Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis.
2005
Objective— Sedentary lifestyle is associated with increased cardiovascular events. The underlying molecular mechanisms are incompletely understood. Reactive oxygen species (ROS) contribute to endothelial dysfunction and atherosclerosis. An important source of vascular ROS is the NADPH oxidase. Methods and Results— C57BL6 mice were subjected to regular housing (physical inactivity) or voluntary training on running wheels (6 weeks). Inactivity increased vascular lipid peroxidation to 148±9% and upregulated superoxide release to 176±17% (L-012 chemiluminescence) and 188±29% (cytochrome C reduction assay), respectively. ROS production was predominantly increased in the endothelium and the medi…
Rac1 protein signaling is required for DNA damage response stimulated by topoisomerase II poisons.
2012
To investigate the potency of the topoisomerase II (topo II) poisons doxorubicin and etoposide to stimulate the DNA damage response (DDR), S139 phosphorylation of histone H2AX (γH2AX) was analyzed using rat cardiomyoblast cells (H9c2). Etoposide caused a dose-dependent increase in the γH2AX level as shown by Western blotting. By contrast, the doxorubicin response was bell-shaped with high doses failing to increase H2AX phosphorylation. Identical results were obtained by immunohistochemical analysis of γH2AX focus formation, comet assay-based DNA strand break analysis, and measuring the formation of the topo II-DNA cleavable complex. At low dose, doxorubicin activated ataxia telangiectasia m…