Search results for "REE"

Professional agency in a university context: Academic freedom and fetters

2020

Professional agency is an urgent topic in academic contexts, albeit relatively unexplored, and elaborated with contradictory conclusions on its extent and characteristics. To contribute to the discussion, this multimethod study investigated professional agency within a Finnish university. We utilised questionnaire data and interviews to explore agency, as manifested in influencing at work, developing work practices, and negotiating professional identity. We found that overall, these three dimensions of agency were manifested fairly substantially, and in a similar manner among the academic staff. The study further emphasises the social nature of professional agency, and presents theoretical …

A dynamic multiple receptor conformations (MD-MRC) approach to enhance early enrichment in virtual screening. A case study on PPAR-alpha

2016

Crecimiento inicial de Eugenia stipitata, Inga spectabilis e Inga edulis en Napo, Ecuador

2018

Agriculture has been one of the causes of deforestation, causing environmental impact and soil degeneration, which leads to lower income earned by farmers; hence the need to implement agroforestry systems .This research aims to describe fromthe initial growth of Eugenia stipitata, Inga edulis, and Inga spectabilis to 320 days after emergence. The study took place at the Amazon Research and Conservation Center of the Amazonas State University, during 2014 and 2015. The growth process was evaluated in regards to plant height, stem diameter, number of leaves, and branch length. Plant height and stem diameter were compared over time applying variance analysis. Precipitation was also compared to…

Indirect chronology method employing rare earth elements to identify Sagunto Castle mortar construction periods

2017

A novel indirect chronology method has been developed to identify Sagunto Castle construction periods. The method is based on the use of inductively coupled plasma mass spectrometry (ICP-MS) to determine rare earth elements (REE) and other trace elements in mortars. Additionally, a no destructive geochemical analysis based on X-ray fluorescence (XRF) was employed for major elements determination. Collected chemical data were processed through Principal Component Analysis (PCA) to highlight any differences among the mortars belonging to different buildings and construction periods. The results show that PCA analysis permits to discriminate construction periods according to mortar sample REE …

Search for Electron Antineutrino Appearance in a Long-baseline Muon Antineutrino Beam

2020

Electron antineutrino appearance is measured by the T2K experiment in an accelerator-produced antineutrino beam, using additional neutrino beam operation to constrain parameters of the Pontecorvo-Maki-Nakagawa-Sakata (PMNS) mixing matrix. T2K observes 15 candidate electron antineutrino events with a background expectation of 9.3 events. Including information from the kinematic distribution of observed events, the hypothesis of no electron antineutrino appearance is disfavored with a significance of 2.40 σ and no discrepancy between data and PMNS predictions is found. A complementary analysis that introduces an additional free parameter which allows non-PMNS values of electron neutrino and a…

The role of in situ species diversification for the evolution of high vascular plant species diversity in the European Alps—A review and interpretati…

2017

Abstract By harbouring ca. 3500 native vascular plant species in an area of ca. 170 000 km2, the European Alps represent a region of very high species diversity. Using the most recently published flora of the area and phylogenetic literature, I here review which proportion of the endemic flora of the Alps is the result of in situ diversification, i.e., of diversification in the area and (largely) restricted to the area. There exist only very few and mostly species-poor species diversifications in the Alps, accounting for ca. 1.2% of the native and for ca. 9% of the endemic flora of the Alps. In contrast to this, ca. 33% of the endemic species of the Alps belong to lineages widespread in the…

Myotonic dystrophy: candidate small molecule therapeutics

2017

Myotonic dystrophy type 1 (DM1) is a rare multisystemic neuromuscular disorder caused by expansion of CTG trinucleotide repeats in the noncoding region of the DMPK gene. Mutant DMPK transcripts are toxic and alter gene expression at several levels. Chiefly, the secondary structure formed by CUGs has a strong propensity to capture and retain proteins, like those of the muscleblind-like (MBNL) family. Sequestered MBNL proteins cannot then fulfill their normal functions. Many therapeutic approaches have been explored to reverse these pathological consequences. Here, we review the myriad of small molecules that have been proposed for DM1, including examples obtained from computational rational …

Does δ-sarcoglycan-associated autosomal-dominant cardiomyopathy exist?

2009

In this study we clinically and genetically characterize a consanguineous family with a homozygous novel missense mutation in the delta-sarcoglycan gene and a second delta-sarcoglycan mutation that has previously been reported to cause severe autosomal-dominant dilated cardiomyopathy. We identified a novel missense mutation in exon 6 (p.A131P) of the delta-sarcoglycan gene, which in a homozygous state leads to the clinical picture of a limb girdle muscular dystrophy. In four heterozygous carriers for the mutation, aged 3-64 years, a second sequence variant in exon 6 (p.S151A) of the delta-sarcoglycan gene was detected on the other allele. This second missense change had previously been repo…

Pfeiffer syndrome: clinical and genetic findings in five Brazilian families

2014

Pfeiffer syndrome (PS) is mainly characterized by craniosysnostosis, midface hypoplasia, great toes with partial syndactyly of the digits and broad and medially deviated thumbs. It is caused by allelic mutations in the fibroblast growth factor receptor 1 and 2 (FGFR1 and 2) genes. This study describes the clinical and genetic features of five Brazilian families affected by PS. All patients exhibited the classical phenotypes related to PS. The genetic analysis was able to detect the mutations Cys278Phe, Cys342Arg, and Val359Leu in three of these families. Two mutations were de novo, with one familial. We identified pathogenic mutations in four PS cases in five Brazilian families by PCR seque…

A comparison of lumbopelvic motion patterns and erector spinae behavior between asymptomatic subjects and patients with recurrent low back pain durin…

2015

Objectives: The purpose of this study was to determine the patterns of lumbopelvic motion and erector spinae (ES) activity during trunk flexion-extension movements and to compare these patterns between patients with recurrent low back pain (LBP) in their pain-free periods and matched asymptomatic subjects. Methods: Thirty subjects participated (15 patients with disc herniation and recurrent LBP in their pain-free periods and 15 asymptomatic control subjects). A 3-dimensional videophotogrammetric system and surface electromyography (EMG) were used to record the angular displacements of the lumbar spine and hip in the sagittal plane and the EMG activity of the ES during standardized trunk fle…