Search results for "REE"
showing 10 items of 13625 documents
Intron variants of the p53 gene are associated with increased risk for ovarian cancer but not in carriers of BRCA1 or BRCA2 germline mutations
1999
Two biallelic polymorphisms in introns 3 and 6 of the p53 gene were analysed for a possible risk-modifying effect for ovarian cancer. Germline DNA was genotyped from 310 German Caucasian ovarian cancer patients and 364 healthy controls. We also typed 124 affected and 276 unaffected female carriers with known deleterious BRCA1 or BRCA2 germline mutation from high-risk breast-ovarian cancer families. Genotyping was based on PCR and high-resolution gel electrophoresis. German ovarian cancer patients who carried the rare allele of the MspI restriction fragment length polymorphism (RELP) in intron 6 were found to have an overall 1.93-fold increased risk (95% confidence internal (CI) 1.27–2.91) w…
I paesaggi tradizionali dell'Etna. Metodologie per l'analisi, la tutela e la valorizzazione.
2012
Aree rurali e nuove opportunità dal Piano di Sviluppo Rurale. Studio dell’area “rur-interna” della provincia nissena
2017
In un momento storico che vede le tematiche ambientali e la dimensione locale quali costanti multiscalari delle strategie di sviluppo locale sostenibile, un ruolo da protagonista sembra essere svolto dall’agricoltura che ha (di)segnato il paesaggio naturale. All’attività agricola, infatti, si riconosce da sempre il contributo allo sviluppo economico e, più di recente, anche una funzione essenziale nella gestione del territorio e per la salvaguardia di alcuni importanti servizi ecosistemici, La Politica Agricola Comunitaria (PAC) e i Programmi di Sviluppo Rurale (PSR), che declinano la politica di sviluppo rurale a scala nazionale e regionale, possono rappresentare strumenti per contenere i …
Strategia per valorizzare un’area interna della regione agrigentina a partire dal patrimonio materiale e immateriale
2015
Il contributo, muovendo da un quadro esemplificativo delle caratteristiche delle aree interne della Sicilia, si sofferma ad analizzare – anche mediante l’analisi SWOT – una porzione di territorio dell’ ex provincia di Agrigento caratterizzata da fragilità, isolamento e da dinamiche di spopolamento tipiche dei contesti marginali. Nell’intento ultimo di attivare uno sviluppo autosostenibile, si propone una strategia mirata al turismo relazionale che porti ad una valorizzazione integrata del suddetto territorio, facendo leva sulle risorse ambientali (sistemi agricoli, paesaggi naturali e antropici), culturali (beni archeologici, insediamenti storici, edifici di culto, miniere abbandonate), sul…
Perspectiva diacrónico-contrastiva del paisaje lingüístico de la migración en el barrio de Ruzafa de Valencia
2019
Este trabajo tiene como principal objetivo conocer el grado de presencia de las lenguas de inmigración en el paisaje lingüístico (PL) de Ruzafa en los años 2008 y 2018 desde un planteamiento diacrónico y contrastivo, así como explorar las consecuencias que ha tenido el proceso de gentrificación sobre el paisaje lingüístico de la migración en el barrio. Para ello se ha elaborado un corpus de un total de 212 signos del PL a partir de capturas de pantalla de las imágenes de Google Street View, las cuales pertenecen los años 2008 y 2018 y muestran los rótulos y signos de algunos comercios privados del barrio. En el análisis se han tenido en cuenta las lenguas que aparecen en los signos, el tipo…
Yrityskoko ja palkat : tarkastelu vuosien 2003-2009 palkkarakennetilastolla
2011
Suuret yritykset maksavat pieniä yrityksiä suurempia palkkoja. Havaittavilta ominaisuuksiltaan samankaltainen työntekijä ansaitsee tyypillisesti samassa työtehtävässä suuressa yrityksessä enemmän kuin pienessä yrityksessä. Yrityskoon ja palkkatason välinen korrelaatio on kansainvälisesti laajalti dokumentoitua, joskaan korrelaation taustalla vaikuttavista syistä ei kirjallisuudessa ole yhteisymmärrystä. Yrityskoon ja palkkatason yhteyttä on selitetty neoklassisin sekä epätäydellisiä markkinoita korostavin teorioin. Empiirinen kirjallisuus on löytänyt molemmille teoriasuunnille hajanaista tukea. Tässä pro gradu -tutkielmassa tarkastellaan yrityskoon yhteyttä palkkatasoon Suomessa hyödyntäen …
Achieving agreement on service needs in child protection : Comparing children’s, mothers’ and practitioners’ views over time and between approaches
2022
Purpose While studies on service users’ participation and their perceptions on the quality of services exist, agreement between family members’ and practitioners’ assessments of the family’s situation has received less interest. The purpose of this paper is to investigate agreement and its effect on outcomes by comparing the viewpoints of three groups of informants (children, mothers and practitioners) in the context of statutory child protection in two study groups – one applying a systemic approach (SPM) and a service-as-usual control group (SAU). Design/methodology/approach A quasi-experimental repeated-measures study design was applied. Outcome data comprised 112 cases (SPM cases n = 5…
Proto-Indo-European verbal suppletion and emerging paradigms
2008
The existence of suppletion in a Proto-Indo-European language is still a question of debate (García Ramón 2002). While the evidence for such a phenomenon has been widely recognized within the verbal system of most Indo-European languages, some scholars describe it as a recent monoglot development which characterizes the history of each single language without involving a previous common stage. According to Strunk (1977), the hypothesis of a PIE suppletive paradigm based on the alternation of verbal roots such as *es- and *bhu- “be”, or *ei-/i- and *gwa-/ gwem - “go”, must be ruled out because it violates the so-called criterium-b, i.e. complementary distribution of the forms involved in a s…
Evolutionary Dynamics of Pathoadaptation Revealed by Three Independent Acquisitions of the VirB/D4 Type IV Secretion System in Bartonella
2017
The α-proteobacterial genus Bartonella comprises a group of ubiquitous mammalian pathogens that are studied as a model for the evolution of bacterial pathogenesis. Vast abundance of two particular phylogenetic lineages of Bartonella had been linked to enhanced host adaptability enabled by lineage-specific acquisition of a VirB/D4 type IV secretion system (T4SS) and parallel evolution of complex effector repertoires. However, the limited availability of genome sequences from one of those lineages as well as other, remote branches of Bartonella has so far hampered comprehensive understanding of how the VirB/D4 T4SS and its effectors called Beps have shaped Bartonella evolution. Here, we repor…