Search results for "REF"
showing 10 items of 8690 documents
Epithelial markers and differentiation in adnexal neoplasms of the skin: an immunohistochemical study including individual cytokeratins
1995
Applying immunohistochemical procedures for the detection of eight different cytokeratin (CK) polypeptides and other differentiation markers, we compared the staining patterns of normal cutaneous structures with those of benign adnexal tumors (n = 65). Syringomas exhibited a marker pattern highly reminiscent of that seen in normal dermal eccrine ducts (EMA in peripheral cells, CK 10 in intermediate cells, and CK 6, CK 19, and CEA in luminal cells). Nodular hidradenomas exhibited complex patterns suggesting relationship between tumor cells, including clear cells, and normal secretory coil cells (CK 7, CK 8, CK 19, and EMA); however, dermal-duct and epidermoid differentiation were also detect…
Multiple endocrine neoplasia type 1 gene expression is normal in sporadic adrenocortical tumors.
2000
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder with neoplasia of the anterior pituitary, the parathyroid, the endocrine pancreas and other endocrine tissues including the adrenal cortex. The tumor-suppressor gene causing this disease was identified at the gene locus 11q13. We recently reported that adrenocortical carcinomas frequently show loss of heterozygosity (LOH) of 11q13, but do not contain point mutations within the MEN1-coding region. To investigate whether reduced gene expression (for example by mutations within the MEN1 promoter) may contribute to the tumorigenesis of sporadic adrenocortical tumors, 24 adrenocortical specimen were studied by Northern …
Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS
2010
Summary Using exome sequencing, we identified a p.R191Q amino acid change in the valosin-containing protein ( VCP ) gene in an Italian family with autosomal dominantly inherited amyotrophic lateral sclerosis (ALS). Mutations in VCP have previously been identified in families with Inclusion Body Myopathy, Paget disease, and Frontotemporal Dementia (IBMPFD). Screening of VCP in a cohort of 210 familial ALS cases and 78 autopsy-proven ALS cases identified four additional mutations including a p.R155H mutation in a pathologically proven case of ALS. VCP protein is essential for maturation of ubiquitin-containing autophagosomes, and mutant VCP toxicity is partially mediated through its effect on…
Vestigios documentales de una fiscalidad recién nacida: Las "Generalitats" valencianas
1996
Durante los siglos finales de la Edad Media, una nueva fiscalidad nació en buena parte de Europa occidental como consecuencia del crecimiento experimentado por las necesidades pecuniarias de nuestros soberanos. Y el reino de Valencia no fue una excepción. En este artículo, sin embargo, no estudiaremos todo ese proceso de renovación fiscal, sino exclusivamente la forma que ese nuevo sistema fiscal adoptó en Valencia para recaudar el donativo concedido al rey Pedro IV por las Cortes de 1373-74.
Immigration Detention and Rule of Law in Italy
2013
Immigration detention challenges the principles of Rule of Law. Illustrating Italian law, case-law and legal practice on Administrative Detention, this research paper contributes to the discussion on common European guiding principles, called 'safeguarding principles' in the context of a funded research project led by researchers of the British Institute of International and Comparative Law
Sociālās politikas izmaiņas Latvijas pašvaldībās pēc Administratīvi teritoriālās reformas
2022
Bakalaura darba tēma ir “Sociālās politikas izmaiņas Latvijas pašvaldībās pēc Administratīvi teritoriālās reformas. Pētījuma mērķis ir izpētīt kā tiek veidota sociālā politika Latvijas pašvaldībās pēc ATR un saprast kādas ir būtiskākās sociālās politikas izmaiņas Latvijas pašvaldībās ar laiku pirms ATR. Bakalaura darba ietvaros ir analizētas pētījumā izveidotās aptaujas atbildes ar pētījumā atlasīto pašvaldību darbiniekiem. Pētījuma ietvaros ir analizēti pašvaldību 2022.gada budžeti un salīdzināti ar apvienoto novadu 2020.gada budžeta ieņēmumiem un izdevumiem. Atslēgas vārdi: “Sociālā politika”, “Latvijas pašvaldības”, “Administratīvi teritoriālā reforma”.
Effects of gait speed on stability of walking revealed by simulated response to tripping perturbation
2013
The objective of this work was to study stability of walking over a range of gait speeds by means of muscle-driven simulations. Fast walking has previously been related to high likelihood of falling due to tripping. Various measures of stability have shown different relationships between walking speed and stability. These measures may not be associated with tripping, so it is unclear whether the increase in likelihood of falling is explicable by an increase in instability. Here, stability with respect to a constant tripping perturbation was quantified as the immediate passive response of torso to the perturbation. Subject-specific muscle-driven simulations of eight young healthy subjects wa…
Neuroimmune Activation and Myelin Changes in Adolescent Rats Exposed to High-Dose Alcohol and Associated Cognitive Dysfunction: A Review with Referen…
2014
Aims: The aim of the study was to assess whether intermittent ethanol administration to adolescent rats activates innate immune response and TLRs signalling causing myelin disruption and long-term cognitive and behavioural deficits. Methods: We used a rat model of intermittent binge-like ethanol exposure during adolescence. Results: Binge-like ethanol administration to adolescent rats increased the gene expression of TLR4 and TLR2 in the prefrontal cortex (PFC), as well as inflammatory cytokines TNF alpha and IL-1 beta. Up-regulation of TLRs and inflammatory mediators were linked with alterations in the levels of several myelin proteins in the PFC of adolescent rats. These events were assoc…
Sonographic biometry of liver and spleen size in childhood.
1983
In 194 healthy children of all ages, sonographic measurements of the liver and spleen were performed on standardized section planes and normal values established. These measurement values showed an approximately linear increase in the course of development and correlated best with the body length. For a rapid orientational evaluation of the liver size, sonographic nomograms of the individual measurements were developed. The spleen size was determined by volume calculation. On the basis of an index of liver size, which was calculated from the individual measurements, a diagram for simultaneous determination of liver and spleen size could be developed. These nomograms permit objective morphom…
Covert digital manipulation of vocal emotion alter speakers' emotional states in a congruent direction
2016
International audience; Research has shown that people often exert control over their emotions. By modulating expressions, reappraising feelings, and redirecting attention, they can regulate their emotional experience. These findings have contributed to a blurring of the traditional boundaries between cognitive and emotional processes, and it has been suggested that emotional signals are produced in a goal-directed way and monitored for errors like other intentional actions. However, this interesting possibility has never been experimentally tested. To this end, we created a digital audio platform to covertly modify the emotional tone of participants' voices while they talked in the directi…