Search results for "REF"

cGMP MODULATES STEM CELLS DIFFERENTIATION TO NEURONS IN BRAIN IN VIVO

2010

During brain development neural stem cells may differentiate to neurons or to other cell types. The aim of this work was to assess the role of cGMP (cyclic GMP) in the modulation of differentiation of neural stem cells to neurons or non-neuronal cells. cGMP in brain of fetuses was reduced to 46% of controls by treating pregnant rats with nitroarginine-methylester (L-NAME) and was restored by co-treatment with sildenafil.Reducing cGMP during brain development leads to reduced differentiation of stem cells to neurons and increased differentiation to non-neuronal cells. The number of neurons in the prefrontal cortex originated from stem cells proliferating on gestational day 14 was 715 +/- 14/…

2019

Muscle architecture is an important component of muscle function, and recent studies have shown changes in muscle architecture with fatigue. The stretch-shortening cycle is a natural way to study human locomotion, but little is known about how muscle architecture is affected by this type of exercise. This study investigated potential changes in medial gastrocnemius (MG) muscle architecture after exhaustive stretch-shortening cycle exercise. Male athletes (n = 10) performed maximal voluntary contractions (MVC) and maximal drop jump (DJ) tests before and after an exercise task consisting of 100 maximal DJs followed by successive rebound jumping to 70% of the initial maximal height. The exerci…

Knee extension strength and walking speed in relation to quadriceps muscle composition and training in elderly women.

1994

Summary. Knee extension strength, walking speed, quadriceps muscle mass and composition of the muscle compartment were studied in 66 to 85-year-old female athletes and controls. Maximal voluntary knee extension force, force/body mass, extension torque, torque/body mass and walking speed were higher for the athletes than the controls. A muscle index indicating intramuscular fat and connective tissue measured using ultrasonography was lower for the athletes than the controls. There were no differences between the study groups in knee extension force related either to cross-sectional area (CSA) or lean tissue area (CSAL) of the quadriceps. Within the subgroups, there was no significant correla…

Causal linear parametric model for baroreflex gain assessment in patients with recent myocardial infarction

2001

Spectral and cross-spectral analysis of R-R interval and systolic arterial pressure (SAP) spontaneous fluctuations have been proposed for noninvasive evaluation of baroreflex sensitivity (BRS). However, results are not in good agreement with clinical measurements. In this study, a bivariate parametric autoregressive model with exogenous input (ARXAR model), able to divide the R-R variability into SAP-related and -unrelated parts, was used to quantify the gain (αARXAR) of the baroreflex regulatory mechanism. For performance assessing, two traditional noninvasive methods based on frequency domain analysis [spectral, baroreflex gain by autogressive model (αAR); cross-spectral, baroreflex gain…

Practical recommendations for the application of DE 59/2013

2019

The changes introduced with Council Directive 2013/59/Euratom will require European Member States adapt their regulations, procedures and equipment to the new high standards of radiation safety. These new requirements will have an impact, in particular, on the radiology community (including medical physics experts) and on industry. Relevant changes include new definitions, a new dose limit for the eye lens, non-medical imaging exposures, procedures in asymptomatic individuals, the use and regular review of diagnostic reference levels (including interventional procedures), dosimetric information in imaging systems and its transfer to the examination report, new requirements on responsibiliti…

Effects of Textured Compression Socks on Postural Control in Physically Active Elderly Individuals

2014

The aim of this investigation was to analyze the role of textured compression socks on somatosensory function in a sample of physically active elderly individuals when performing a static balancing task. Both textured insoles and athletic tape are deemed to be beneficial for enhancing proprioception because of the capacity for exploiting availability of “sensorimotor system noise”, which enhances movement control and individuals’ joint position perception. It was hypothesized that the compression feature in knee length socks would provide greater stimulation to lower leg mechanoreceptors, and help participants achieve better balance control. Participants (N=8) performed a 30-s Romberg stati…

Precuneus and insular hypoactivation during cognitive processing in first-episode psychosis: Systematic review and meta-analysis of fMRI studies

2020

Abstract Introduction The neural correlates of the cognitive dysfunction in first-episode psychosis (FEP) are still unclear. The present review and meta-analysis provide an update of the location of the abnormalities in the fMRI-measured brain response to cognitive processes in individuals with FEP. Methods Systematic review and voxel-based meta-analysis of cross-sectional fMRI studies comparing neural responses to cognitive tasks between individuals with FEP and healthy controls (HC) according to PRISMA guidelines. Results Twenty-six studies were included, comprising 598 individuals with FEP and 567 HC. Individual studies reported statistically significant hypoactivation in the dorsolatera…

Å være pårørende når alternativ behandling tas i bruk i “kampen mot kreft”

2015

<strong>Being relatives when alternative therapies are used in the "fight against cancer"</strong><br />CAM (Complementary and Alternative Medicine) is prevalent among cancer patients. Relatives are central to support and care for the patient but experience challenges and stresses in this role. The purpose of this study was to gain knowledge of how it is experienced to be relative of people with terminal cancer who seeks CAM. Five qualitative semi-structured in-depth interviews of relatives and nine biographies written by relatives were analyzed using systematic text condensation. Results showed that relatives experienced to fight for hope in a given battle, not knowing wh…

The use of clinical guidelines for referral of patients with lesions suspicious for oral cancer may ease early diagnosis and improve education of hea…

2010

UNLABELLED Early diagnosis and referral of oral cancer is essential. Successful implementation of clinical guidelines must include current practitioners and students. OBJECTIVE To evaluate the diagnostic accuracy of students at oral cancer screening and to assess the effectiveness of clinical referral guidelines. STUDY DESIGN Fifth year dental students were randomly allocated to either control (n=19) or experimental groups (n = 18). Both received the customary training in oral diagnosis. The experimental group underwent a 2 hour workshop where the guidelines for the referral of suspicious lesions were discussed. Three months later, a set of 51 clinical cases including benign, malignant, and…

Implementation of a strategy involving a multidisciplinary mobile unit team to prevent hospital admission in nursing home residents: protocol of a qu…

2020

IntroductionNursing home residents represent a particularly vulnerable population experiencing high risk of unplanned hospital admissions, but few interventions have proved effective in reducing this risk. The aim of this research will be to verify the effects of a hospital-based multidisciplinary mobile unit (MMU) team intervention delivering urgent care to nursing home residents directly at their bedside.Methods and analysisFour nursing homes based in the Parma province, in Northern Italy, will be involved in this prospective, pragmatic, multicentre, 18-month quasiexperimental study (sequential design with two cohorts). The residents of two nursing homes will receive the MMU team care int…