Search results for "REGENERATION"
showing 10 items of 889 documents
Optogenetics in Stem Cell Research: Focus on the Central Nervous System
2017
Stem cell-based therapies of CNS disorders represent a promising approach in translational and regenerative medicine. Stem cell-based tissue replacement and regeneration would, for the first time, offer a causal treatment strategy which is most likely not bound to a specific time window. Therapeutic strategies relying on this paradigm would require administration of exogenous stem cells to the CNS and/or the augmentation of endogenous stem cell capabilities. However, it remains unclear whether tissue replacement or bystander effects are required to induce such effects. Conventional experimental techniques will not be able to causally reveal such information, due to the complexity and coinci…
Improving the Techniques for Human Hepatocyte Transplantation: Report from a Consensus Meeting in London
2012
On September 6 and 7, 2009 a meeting was held in London to identify and discuss what are perceived to be current roadblocks to effective hepatocyte transplantation as it is currently practiced in the clinics and, where possible, to offer suggestions to overcome the blocks and improve the outcomes for this cellular therapy. Present were representatives of most of the active clinical hepatocyte transplant programs along with other scientists who have contributed substantial basic research to this field. Over the 2-day sessions based on the experience of the participants, numerous roadblocks or challenges were identified, including the source of cells for the transplants and problems with tra…
Infrastructure as Interface: Thinking the Urban and the High-speed Railway Station: Italian Case-studies
2013
The recent launching in Italy of a number of large scale urban operations centered around High Speed Railway (HSR) stations has added a wealth of examples and themes to the overall European picture; these go to make up a global point of reference for other countries that are, in this period, undertaking the construction of their own HSR networks. Above and beyond the territorial questions often linked to the issue, further research investigating the architectural aspect of these operations would be highly relevant, but is rather lacking. Instead, we shall be focusing on current HSR stations in Italy, such as Turin Porta Susa, Florence Belfiore and Rome Tiburtina, and comparing them briefly,…
Does granulocyte-colony stimulating factor stimulate peripheral nerve regeneration? An experimental study on traumatic lesion of the sciatic nerve in…
2021
Aim of the study. To analyse the therapeutic potential of granulocyte-colony stimulating factor (G-CSF) treatment using a rat model of traumatic sciatic nerve lesion. Clinical rationale for the study. G-CSF has proven strong neurotrophic properties in various models of ischaemic and traumatic brain injury. Fewer studies exist regarding the influence of G-CSF on posttraumatic peripheral nerve regeneration. Currently, the possibilities of pharmacological prevention or treatment of mechanical nerve injury are limited, and there is an urgent need to find new treatment strategies applicable in clinical situations. Material and methods . A controlled traumatic right sciatic nerve lesion was set u…
Sonic Hedgehog-Mediated Synergistic Effects Guiding Angiogenesis and Osteogenesis
2012
Sonic hedgehog (Shh) is a morphogen controlling the skeletal and vascular development in the embryo but is also reactivated during adult repair processes. Thus, this molecule holds great therapeutic potential for biotechnological and biomedical approaches aiming to enhance tissue regeneration or to replace damaged tissues. According to present knowledge, Shh signaling controls the expression of several families of growth factors involved in neovascularization and vessel maturation and acts upstream of the most prominent angiogenic growth factor, vascular endothelial growth factor. In this context, a very interesting feature of Shh is that it controls both angiogenic activity and vessel stab…
Re-think, Re-load, Re-cycle: Mediterranean Urban Metamorphosis
2013
Metamorphosis is the new and powerful keyword in time of crisis. We are not undergoing a mere -even though dramaticpassing situation, but we are living in a crisis which requires a metamorphosis of the ecological, cultural, economic, social and political systems to get out of it other than we were when entering it. The metamorphosis will have to be mainly urban, because we are now in the Urban Age in which more than half the population live and work in cities, at levels exceeding 80% in Europe. The city, as the predominant form of inhabiting, is invested with the “responsibility” of producing innovative, more sustainable, intelligent and creative life styles, able of generating the innovati…
Re-imagine, Re-load, Re-cycle: New Urbanism for the City of Future
2014
The failure of European development model based on financial protocols urges the need to "re-think capitalism" toward a greater spatial dimension and a different approach in the use/reuse/reduction of the capitals utilised in development processes. Especially in Mediterranean Europe we have to restart from urban capitals (space, identity, quality, service and production) using them as renewed engines of sustainable growth (RE-IMAGINE). In the global change scenario, the shrinking city produces several urban "fragments", functional "chips" and "scraps" of development that, through a recycling process/project, can be brought back into urban infrastructures for new cycles of life (RE-CYCLE). T…
Re-cycle: molecolare/sistemico
2014
Il modello di sviluppo dopato entro cui abbiamo vissuto consolati dalle sue aporie ha prodotto una costante erosione di risorse urbane, di cui quella del suolo è solo una sineddoche, sebbene la più evidente. Abbiamo consumato soprattutto le strutture identitarie dei palinsesti culturali e le trame vegetali delle città, abbiamo anestetizzato metabolismi vitali e interrotto i cicli delle acque, dei rifiuti e della mobilità rendendoli inefficaci. Abbiamo eroso la capacità dell'urbano di intrattenere una relazione osmotica con il rurale, abbiamo sedato la capacità produttiva e generativa delle manifatture, così come abbiamo dimenticato il valore rigenerativo della manutenzione edilizia. La cris…
Re-cyclical Urbanism. Visions, Paradigms and Projects for the Circular Metamorphosis
2017
The European Commission has clearly stated that more intelligent, sustainable and competitive development requires a paradigm shift in which the territory is construed as a primary resource, considered the holder of “development cells”, which are too often underused or mystified with regard to their real potential for use (EC, Directorate-General for Research and Innovation, 2012). Cities designed and built on land rent — on which Italy set a benchmark — need to be replaced with cities of social and cultural profitability, value creation and jobs production. Cities that recycle already-used land to avoid energy waste, smarter cities — not just technologically, but also wiser and more sentie…
COLLAGE CITY. RIGENERAZIONE URBANA PER LA CITTA' DI TARANTO
2023
The paper returns, in a critical key, the results of the design experimentation developed by the Politecnico di Milano working group that has tackled the theme of the architectural and urban regeneration of the areas of Tamburi, Salinella and Paolo VI in Taranto, a broader reflection on the techniques, strategies and methodologies applied according to the new objectives defined by the United Nations Urban Agenda for the development of urban policies on the theme of social inclusion, economic and environmental sustainability. The three areas represent singular case studies peculiar to the design culture in our country of public housing and their settlement models and mark the different histo…