Search results for "REGIME"

Phase Ib Trial Trial of Rg7116, a Glycoengineered Monoclonal Antibody Targeting Her3, in Combination with Cetuximab or Erlotinib in Patients with Adv…

2014

ABSTRACT Aim: To evaluate the safety profile of RG7116 in combination with cetuximab or erlotinib. Methods: Patients (pts) with advanced or metastatic carcinomas with centrally confirmed HER3 protein expression were included. RG7116 plus cetuximab (400 mg/m2 followed by 250 mg/m2 qw IV) and RG7116 plus erlotinib (150 mg/day p.o.) combinations were evaluated in a dose escalation study with “3 + 3” design at a starting dose of 400 mg IV of RG7116 in a q2w regimen. Results: Twenty-seven pts were enrolled in 5 cohorts (400 to 2000 mg) in the cetuximab arm. One dose-limiting toxicity (DLT) of grade 3 dehydration was reported in the 800-mg cohort. Twenty-seven pts were enrolled in 4 cohorts (400 …

Estimating the substitutability between private and public consumption: the case of Spain, 1960–2003

2005

This paper examines the relationship between private and public consumption using Spanish data over the period 1960–2003, using a two-good permanent-income model. We extend previous analysis addressing the question of whether this relationship is stable over time, or exhibits a structural break allowing the instability to occur at an unknown point in time. Our empirical results indicated the existence of a long-run relationship between private and public consumption. We also detect a structural change of regime shift in the cointegration regression around the time of 1973–74. Finally, the estimated intratemporal and intertemporal elasticities of substitution between the two types of expendi…

Lone mothers and the puzzles of daily life: do care regimes really matter?

2010

Kroger T. Lone mothers and the puzzles of daily life: do care regimes really matter? Int J Soc Welfare 2010: 19: 390–401 © 2009 The Author, Journal compilation © 2009 Blackwell Publishing Ltd and the International Journal of Social Welfare. This article studies childcare patterns and day-to-day strategies of 111 working lone mothers from Finland, France, Italy, Portugal and the UK, and asks whether their arrangements are prescribed by care regimes. Lone mothers' arrangements are grouped into five based on the availability and use of different formal and informal childcare resources. The article argues that, even though lone mothers have a more favourable starting point in Finland and France…

Iron operates as an important factor promoting year-round diazotrophic cyanobacteria blooms in eutrophic reservoirs in the tropics

2021

Abstract We hypothesize that iron availability plays an important role in driving phytoplankton structure and dynamics in tropical reservoir. This role has often been neglected in routine monitoring of water quality since the main focus has been addressed on macronutrients such phosphorus and nitrogen. To elucidate the potential regulation exerted by iron availability on phytoplankton, a limnological investigation was carried out in two neighboring eutrophic reservoirs in tropical China. Traditional physical and chemical variables were measured along with total and dissolved iron concentrations to explore how they could influence phytoplankton structure. Statistical analyses showed that dis…

Current questions for the treatment of advanced gastric cancer.

2013

Abstract Background Gastric cancer remains a major health problem worldwide. Treatment of advanced gastric cancer is controversial and there is no standard regimen for first- or second-line chemotherapy (CT). This review aims to give an overview of the hot topics concerning treatment, prognostic factors and new strategies in advanced gastric cancer. Material and methods Seven questions of special clinical interest have been formulated previously to the literature review. With the aim of answering each of these questions, a specific search of the relevant trials and meta-analyses published or communicated from 1990 to date was performed. Results Patients treated with CT have a survival benef…

Saastumisen kontrollin ideologia : vesien saastumisen ja vesirikosten kontrolli Suomessa vuosina 1960-2000

2011

Structures optiques dissipatives en cavité laser à fibre

2011

This thesis presents a study of the nonlinear dissipative dynamics of localized of self organized structures in passively mode-locked fiber laser through nonlinear polarization evolution. We reveal the existence of a gradual transition from the quasi-cw to mode locked dynamics in the multi-pulsing regime. We emphasize on the intermediate state, where various new dynamics are observed. We study collective behaviors of dissipative solitons in the presence of a continuous background. One of the complex and attractive dynamics presented is the "soliton rain", which composed of three field components : continuous modes of background, drifting of solitons and condensed phase solitons. This dynami…

Theoretical Approach: The Situation-Structural Model as an Analytical Tool to Explain Regionalism

2017

This chapter provides the analytical framework and guiding theory for this work. Muntschick develops an innovative situation-structural model to the analysis of regionalism that goes beyond Euro-centric and classic integration theories because it takes the impact of external actors explicitly into account. This—often neglected—aspect is of crucial importance in regions with mainly developing countries that show strong and asymmetric relations to extra-regional actors. Besides offering clear-cut definitions of regions and regionalism, Muntschick draws on insights from cooperation and regime theory in order to specify assumptions and deduce hypotheses about the emergence, institutional design…

Rituximab for Immune Thrombocytopenia: A Retrospective Analysis on the Role of Prophylaxis Against Pneumocystis Jirovecii and Herpes Zoster Virus

2018

Abstract Introduction and objective of the study Rituximab (RTX) is considered a valid second line treatment option for persistent or chronic Immune Thrombocytopenia (ITP). RTX is known to affect the immune system thus increasing the risk for viral and fungal infections. Although prophylactic treatment to prevent Pneumocystis jirovecii (PJ) and herpes viruses' infections is used in patients with haematological neoplasms receiving RTX, these evidence is lacking in ITP patients candidated to anti-CD20 therapy. We here reported the role of phrophylaxis in a cohort of patients treated with RTX for refractory/relapsed ITP. Methods Data from patients affected by ITP and treated at our Institution…

Letter to the Editor regarding the paper by Aurilio et al., A meta-analysis of oestrogen receptor, progesterone receptor and human epidermal growth f…

2014

Sir,We have read with great interest the article in press ofAurilio et al., A meta-analysis of oestrogen receptor, pro-gesterone receptor and human epidermal growth factorreceptor 2 discordance between primary breast cancerand metastases (http://dx.doi.org/10.1016/j.ejca.2003.10.004), which will appear in Eur J Cancer. In the paper,the Authors have performed a meta-analysis of the stud-ies published in the literature concerning the discor-dance rate in oestrogen receptor (ER), progesteronereceptor (PgR) and HER2 status between primarytumour and corresponding relapse. It is well known thata considerable controversy concerns the issue of hor-mone receptors (HRs) expression as well as HER2 sta…