Search results for "REGION"
showing 10 items of 4910 documents
Coincident glutamatergic depolarizations enhance GABAA receptor-dependent Cl- influx in mature and suppress Cl- efflux in immature neurons.
2021
The impact of GABAergic transmission on neuronal excitability depends on the Cl--gradient across membranes. However, the Cl--fluxes through GABAA receptors alter the intracellular Cl- concentration ([Cl-]i) and in turn attenuate GABAergic responses, a process termed ionic plasticity. Recently it has been shown that coincident glutamatergic inputs significantly affect ionic plasticity. Yet how the [Cl-]i changes depend on the properties of glutamatergic inputs and their spatiotemporal relation to GABAergic stimuli is unknown. To investigate this issue, we used compartmental biophysical models of Cl- dynamics simulating either a simple ball-and-stick topology or a reconstructed CA3 neuron. Th…
Decentralization as an incentive scheme when regional differences are large
2010
It has been suggested that large regional differences could be an obstacle to that part of the political accountability of office-holders which is based on yardstick competition among governments. The paper addresses that question and concludes that the obstacle is not too serious in general. The second part of the paper is devoted to the persistent economic underperformance of some regions in countries such as Germany, Italy and (with regard to regions overseas) France. How is it that the mechanism of yardstick competition induces a convergence of economic performance among European Union member countries, even those particularly poor initially, but fails to induce all the underperforming …
A GIS-based method for evaluating the walkability of a pedestrian environment and prioritised investments
2020
Abstract Despite the large investments made in the construction and modernisation of railway infrastructure, poor quality pedestrian routes may discourage users from using public transport. In fact, very little attention is generally paid to pedestrian mobility. Therefore, a method for evaluating the quality of pedestrian paths and the accessibility to railway stations has been developed. This method considers the main factors influencing the walkability of an urban area and makes it possible to establish the priorities for intervention, i.e. to identify the arcs of a pedestrian network that require prioritised action. The methodology is a decision support tool that can be used by policymak…
Smart cities technologies applied to sustainable transport. Open data management
2016
One of the objectives of the Smart Cities is the efficient and sustainable use of transport infrastructures. Sustainability is understood as the application of new technologies to minimize the loss of time and energy, and at the same time, to improve the satisfaction of citizens. Achieving this objective calls for making use of the mobility data collected from the existing transport infrastructure and services, as well as from the citizens themselves. After the data collection process, information must be stored (use of open data bases) and made accessible (available) to specialized applications and users. This paper highlights the opportunity to take advantage of emerging technologies, lik…
Contributions from Informal Geography to Close the Gap in Geographic Information Communication in a Digital World
2019
Contemporary challenges and problems of society demand decision support systems that use geographic information. Even though geography since its origins has been a science with a strong transversal character, society has now made it become the focus of its agenda. Novel and other already established actors are involved in this rediscovery and popularization of geography. Both groups are promoting known and unknown geographical tasks thanks to technology, which is revealing new landscapes of our old territories and showing us the agency capacity of Geography Science. In this chapter, the authors review the offers and demands of communication on geographic information from the informal geogra…
Endocrine disrupter compounds removal in wastewater using microalgae: Degradation kinetics assessment
2018
[EN] This paper describes a study carried out to determine the removal kinetics of four micropollutants (4-tert-octylphenol (OP), technical-nonylphenol (t-NP), 4-nonylphenol (4-NP) and bisphenol-A (BPA)) usually found in wastewater streams. The kinetic experiments were carried out in batch reactors containing the effluent of an Anaerobic Membrane BioReactor (AnMBR) in the presence of light, oxygen and microalgae. As the degradation process of the studied micropollutants obeyed a pseudo-first-order kinetics, the second-order kinetics for each micropollutant was then calculated. The second order rate constants for the hydroxyl radical (k.(OH)) ranged from 7.0.10(+10) to 6.6.10(+12) L.mol(-1).…
Impact of a Three Amino Acid Deletion in the CH2 Domain of Murine IgG1 on Fc-Associated Effector Functions
2008
Abstract Four murine IgG subclasses display markedly different Fc-associated effector functions because of their differential binding to three activating IgG Fc receptors (FcγRI, FcγRIII, and FcγRIV) and C1q. Previous analysis of IgG subclass switch variants of 34-3C anti-RBC monoclonal autoantibodies revealed that the IgG1 subclass, which binds only to FcγRIII and fails to activate complement, displayed the poorest pathogenic potential. This could be related to the presence of a three amino acid deletion at positions 233–235 in the CH2 domain uniquely found in this subclass. To address this question, IgG1 insertion and IgG2b deletion mutants at positions 233–235 of 34-3C anti-RBC Abs were …
Rainwater harvesting in urban areas of developed countries. The state of the art (1980-2017)
2020
Many urban areas suffer from water scarcity although paradoxically, a local source such as rainwater is mostly treated as a risk rather than a valuable resource. This change of paradigm is included in the 'integrated water resources management' and 'demand management' approach. The aim of this research is to identify and analyse studies that explore subject matters concerning rainwater in the integrated management systems of water resources into developed countries. The research methodology consisted in a literature review (from the 1980s to 2017) of territorial studies that examine rainwater harvesting in urban areas of the developed countries. To this end, a bibliometric analysis has been…
Role of the socioeconomic factors and regional policy in the demographic development of Latvia
2017
Promocijas darbā ir izpētīta reģionālā demogrāfiskā attīstība Latvijā ar mērķi noteikt savstarpējās sakarības starp reģionu demogrāfisko dinamiku, to ietekmējošajiem sociāli ekonomiskajiem faktoriem un reģionālās politikas pasākumiem. Darbā uzsvērta laika un telpas dimensija, kas ir ļoti svarīga, atklājot jaunas, iepriekš nekonstatētas reģionālas demogrāfiskās problēmas. Autors secina, ka personīgie ienākumi un nodarbinātība ir pozitīvās reģionālās demogrāfiskās attīstības svarīgākie priekšnosacījumi. Tiek pierādīts, ka ES fondu ieguldījumi spēj pozitīvi ietekmēt dažus demogrāfiskus procesus un to ietekmei ir raksturīgs telpiskās pārteces efekts. Vēsturiskās un telpiskās analīzes rezultāti …
Gravity modelling of the lower crust in Sardinia (Italy)
1997
In this paper an example is given of an application of statistical techniques to the Bouguer anomalies analysis in order to design a simple crustal model using few a priori assumptions. All gravity measurements carried out in Sardinia have been collected and processed. The Bouguer anomalies have been calculated according to local density estimates. Spectral analysis of the Bouguer anomalies has been carried out along selected profiles in order to estimate the mean depth of the Moho discontinuity and that of an infracrustal discontinuity. The use of this technique inferred the presence of a discontinuity at a mean depth of ~ 28 km, interpreted as Moho and the likely presence of an infracrust…