Search results for "REGION"

Mutation Analysis of LMX1B Gene in Nail-Patella Syndrome Patients

1998

SummaryNail-patella syndrome (NPS), a pleiotropic disorder exhibiting autosomal dominant inheritance, has been studied for >100 years. Recent evidence shows that NPS is the result of mutations in the LIM-homeodomain gene LMX1B. To determine whether specific LMX1B mutations are associated with different aspects of the NPS phenotype, we screened a cohort of 41 NPS families for LMX1B mutations. A total of 25 mutations were identified in 37 families. The nature of the mutations supports the hypothesis that NPS is the result of haploinsufficiency for LMX1B. There was no evidence of correlation between aspects of the NPS phenotype and specific mutations.

Role of the nNOS gene in ethanol-induced conditioned place preference in mice

2009

Nitric oxide (NO) produced by neuronal nitric oxide synthase (nNOS) has a role in synaptic plasticity, and evidence suggests its role in a range of effects produced by alcohol in the central nervous system. The aim of the current study was to investigate the role of the nNOS gene in the development of ethanol-induced conditioned place preference (CPP) in mice. The CPP paradigm is designed to investigate the reinforcing properties of drugs of abuse and the development of maladaptive behaviors, such as conditioned response to drug-associated stimuli, following repeated drug exposure. Adult male and female wild type (WT) and nNOS knockout (KO) mice on a mixed B6; 129S genetic background were t…

Calcium Pre-Rinse: Effect on permeability of dentin tubules by fluoride rinse

2019

Background The aim of this study was to evaluate whether calcium (CaL) solution would enhance the capacity of sodium fluoride (NaF) solution in reducing the permeability of hypersensitive dentin. Material and Methods Thirty-two Wistar rats ingested for 45 days acidic isotonic drink (Gatorade, pH 2.7) ad libitum to induce dental erosion. Then, molar teeth received a cold stimulus to confirm the presence and score the intensity of dentin hypersensitivity based on body contraction and noise. Animals were allocated to four groups (n=8), according to the solution(s) applied in the oral cavity: NaF (12 mmol/L, 1 min); CaL (150 mmol/L, 1 min); CaL followed by NaF (CaF+NaF, 1 min each); distilled w…

Nieznane dokumenty dotyczące sejmiku województw poznańskiego i kaliskiego z lat 1701 i 1735 w londyńskich zbiorach archiwalnych. Edycja źródłowa

2022

Odnalezione w londyńskich instytucjach naukowych rękopiśmienne dokumenty związane są z niezwykle burzliwymi okresami w dziejach szlacheckiej Rzeczypospolitej. Instrukcja, a w zasadzie punkty z sejmiku województw poznańskiego i kaliskiego z 1701 r. są związane z początkową fazą Wielkiej Wojny Północnej, która zmieniła układ sił w Europie Środkowo-Wschodniej. Analizowany sejmik został zerwany, a mimo to upubliczniono wyniki jego prac właśnie w formie punktów. Znany polskim historykom dokument nieco odbiega od tego, który znajduje się w londyńskich zbiorach, a różnic, na tym etapie badań, nie jesteśmy w stanie wyjaśnić. Drugi dokument dotyczy tego samego sejmiku, ale z 1735 r., okresu równie b…

European cohesion principle and the institutional and economic development of an insular region: the case of Sicily1

2018

This paper is a tribute dedicated to the memory of Alessandro Argiroffi, professor of philosophy of law and human rights, colleague of the University of Palermo. It was presented at the Local Economic Development Program at the London School of Economics and Political Science - New Academic Building - London March 7, 2015 for the first time, and than in Bilbao, at the Conference “Significado y funcíon de las regiones con autogobierno y parlamentos legislativos en la construccion de la Europa política” organized by Universidad del País Vasco/Euskal Herriko Unibertsitatea, October 10‐11, 2017

The re-emergence of the condition of insularity in the Italian and European legal system

2022

The essay deals with the question of the conditions of insularity in the European and Italian legal systems by analyzing the regulatory evolutions and the studies of the Regions on the subject up to the recognition referred to in the Constitutional law n. 2 of 2022 (art.119, 6 paragraph)

La riemersione della condizione di insularità nell’ordinamento giuridico italiano ed europeo

2022

Il saggio tratta della questione dalle condizione di insularità nell'ordinamento Europeo ed in quello Italiano analizzando le evoluzioni normative e gli studi delle Regioni in merito sino al riconoscimento di cui alla legge Costituzionale n. 2 del 2022 ( art.119, 6 comma)

De-territorialisering av offentlig politikk? : europeisk integrasjon og sub-regionale beslutningsprosesser

2005

Linee guida per l'interpretazione ambientale delle aree protette

2008

Le aree protette, viste dapprima come vincolo dalle popolazioni locali che vi risiedono, hanno acquisito sempre più il ruolo di laboratorio per la sperimentazione di nuove politiche di gestione virtuosa del territorio. Oggi rappresentano luoghi in cui è possibile ricucire il legame tra sviluppo economico, sociale e ambientale attraverso l’arresto dell’uso indiscriminato e irresponsabile delle risorse naturali e l’avvio di processi economici e sociali basati sugli scopi dello sviluppo sostenibile. L’Interpretazione Ambientale rappresenta, all’interno delle politiche di gestione delle aree protette, lo strumento adeguato a progettare e contemperare la fruizione con la conservazione e la tutel…

Rola Szanghajskiej Organizacji Współpracy w procesie międzyregionalnej integracji

2018

Szanghajska Organizacja Współpracy (SZOW) to międzynarodowa organizacja o charakterze rządowym, którą od 8 czerwca 2017 r. tworzy osiem państw członkowskich, a mianowicie: Federacja Rosyjska, Chińska Republika Ludowa, Republika Kazachstanu, Republika Kirgistanu, Republika Uzbekistanu, Republika Tadżykistanu, Republika Indii oraz Islamska Republika Pakistanu. Warto podkreślić, że dwa ostatnie państwa, tj. Republika Indii oraz Islamska Republika Pakistanu, formalnie pozostają w stanie wojny. Zgodnie z art. 1 Karty SZOW do głównych celów analizowanej organizacji należy: umacnianie pokoju, bezpieczeństwa i stabilności w regionie euroazjatyckim, przeciwdziałanie międzynarodowemu terroryzmowi, se…