Search results for "REGION"
showing 10 items of 4910 documents
Web social et multimédia : propriétés d'une relation symbiotique
2011
International audience; Les notions inhérentes aux principes du web social placent les contenus multimédias au cÉur de nouvelles pratiques communicationnelles. Les relations entre les nouveaux espaces de médiation ouverts par le web 2.0 et l'univers du multimédia ne s'inscrivent pas simplement dans un rapport linéaire et séquentiel de transfert d'innovations mais procèdent davantage d'une relation symbiotique aux bénéfices multiples. Dans une première partie nous mettrons en exergue les spécificités de ces relations puis nous questionnerons les nouveaux usages et les nouvelles pratiques qu'elles induisent. Dans une seconde partie, nous présenterons un ensemble de résultats obtenus suite à u…
La Red Trampolín: Multinacionales en Latinoamérica
2014
El tema de la casa matriz regional cuenta con cierto nivel de investigación con respecto a las condiciones que inciden en la evolución de una filial, hasta transformarse en casa matriz regional (Bouquet y Birkinshaw, 2008). Dentro de este mismo orden de ideas, ha surgido el fenómeno de la regionalización debido a la creciente necesidad de atender mercados e industrias más maduras (Adler y Hashai, 2007). A pesar de las aproximaciones realizadas al tema, existe una reorganización a nivel regional en diversos contextos que debe ser estudiada a profundidad (Rugman y Verbeke, 2005 y Arregle, Beamish y Hébert, 2009). Esta investigación tiene como objetivo profundizar en los procesos de regionaliz…
The Assessment of Well-being in Context of Regional Development
2014
The aim of the paper is to present the methodology and results of some empirical research of the assessment of well-being at local level in context of regional development. To achieve the aim, such qualitative and quantitative methods of research as comparing, grouping, graphical analysis and focus group methods were be used. The main result and finding of the paper is the conclusion that in order to promote the regional development of the territory, the assessment of well-being at the level of administrative territory is needed. Based on this assessment, the policy can be developed in order to promote the regional development and social cohesion of the territory, as well as to have better …
The utility of SATB2 immunohistochemical expression in distinguishing between osteosarcomas and their malignant bone tumor mimickers, such as Ewing s…
2016
SATB2 is commonly expressed in osteosarcomas. Although apparently being a valuable diagnostic marker for differentiating between small cell osteosarcoma (SCO) and other small round cell tumors of bone, for instance Ewing sarcoma family of tumors (ESFT), it has not been tested in a large series of ESFT and chondrosarcomas so far. We studied the immunohistochemical expression of SATB2 in 42 osteosarcomas, 31 chondrosarcomas, and 371 genetically confirmed ESFT. SATB2 positivity was detected in 90.4% of osteosarcomas, 87.5% of SCO, 91.3% of osteoblastic osteosarcomas, and in all chondroblastic and parosteal osteosarcomas. The osteoblastic and SCO subtypes expressed SATB2 more intensely than oth…
Derepressing muscleblind expression by miRNA sponges ameliorates myotonic dystrophy-like phenotypes in Drosophila
2016
AbstractMyotonic Dystrophy type 1 (DM1) originates from alleles of the DMPK gene with hundreds of extra CTG repeats in the 3′ untranslated region (3′ UTR). CUG repeat RNAs accumulate in foci that sequester Muscleblind-like (MBNL) proteins away from their functional target transcripts. Endogenous upregulation of MBNL proteins is, thus, a potential therapeutic approach to DM1. Here we identify two miRNAs, dme-miR-277 and dme-miR-304, that differentially regulate muscleblind RNA isoforms in miRNA sensor constructs. We also show that their sequestration by sponge constructs derepresses endogenous muscleblind not only in a wild type background but also in a DM1 Drosophila model expressing non-co…
THU0713 How the variation in the lumbopelvic patterns of movement affects the neuromotor control of the biceps femoris during trunk forward bending
2017
Background Trunk forward bending is one of the most common activities in daily living; it is a two-part movement involving the lumbar spine flexion and pelvis rotation at hip joint. The pattern of movement during forward bending was defined as the relative contribution of the lumbar spine to pelvis motion, and was expressed as the ratio between the ranges of lumbar spine motion to pelvis motion (L/P), which, calculated at certain degrees of trunk flexion during the entire movement, provides the lumbo-pelvic rhythm. This is associated with a specific pattern of activation for back and hip extensor muscles which was coined as flexion relaxation phenomenon, observed either in the erector spina…
EFFECTS OF STRIKING STRATEGY ON LOWER EXTREMITY LOADING DURING RUNNING
2013
Backround It is expected that every second runner has a running-related overuse injury each year. The knee joint and Achilles tendon are the most commonly injured sites covering both about one fifth of all running related injuries. 1 Runners can be categorized into rearfoot strikers, mid-foot strikers or forefoot strikers based on the landing strategy at the instant of initial ground contact. Forefoot or mid-foot striking has been shown to reduce impact peak and loading rate of the ground reaction force during early stance phase. 2 Furthermore, the finding of the recent study suggest that forefoot striking may potentially decrease the risk of running-related injuries. 3 However, the effect …
HLA-B27-restricted T cells from patients with ankylosing spondylitis recognize peptides from B*2705 that are similar to bacteria-derived peptides
2003
SUMMARY Ankylosing spondylitis (AS) is an inflammatory systemic disease affecting the spine, sacroiliacal and peripheral joints. Although the aetiology of AS remains unknown, the strong association with the HLA-B27 allele might reflect directly a detrimental effect of the HLA-B27 molecule itself, resulting from its potential capability to present ‘arthritogenic’ peptides to CD8+ T cells. Because some forms of SpA are triggered by enterobacterial infection, such arthritogenic peptides might originate from autologous and/or bacterial proteins triggering cross-reactive CD8+ T cell clones. Intriguingly, two peptides from the second extracellular domain of HLA-B*2705 share sequence homologies wi…
Plantar pressure distribution analysis in normal weight young women and men with normal and claw feet: a cross-sectional study
2005
We analyzed the plantar support in 72 normal-weight young voluntaries (46 women, 26 men), by a baropodometric platform. We considered subjects with claw foot (CFS) and subjects with normal foot (NFS). We found a significant reduction of total plantar support surface in the CFS (P < 0.0001 for women, P < 0.001 for men), due to the reduction of the forefoot and rear foot areas of both plantar imprints. Indeed, CFS of both sexes exhibited higher values of both plantar pressure and peak pressure, compared to the NFS. Moreover, the load per units of plantar surface increased in CFS compared to the NFS. In conclusion, the reduction of plantar support surfaces in CFS of both sexes was associated t…
Dairy calcium intake and lifestyle risk factors for bone loss in hiv-infected and uninfected mediterranean subjects
2012
Abstract Background Despite the reported high prevalence of osteoporosis in the human immunodeficiency virus (HIV)-population, there have been no previous studies examining dairy calcium intake and bone mineral density (BMD) in HIV-subjects. We assessed the prevalence of low BMD in HIV-infected and uninfected subjects and analyzed the effects of calcium intake, lifestyle and HIV-related risk factors on BMD. Methods One hundred and twelve HIV-infected subjects were consecutively enrolled. Seventy- six HIV-uninfected subjects matched for age and sex were enrolled as the control group. The HIV-subjects were interviewed about lifestyle habits and completed a weekly food-frequency questionnaire …