Search results for "REGION"
showing 10 items of 4910 documents
Understanding the health care pattern of homeless children through their residential journey
2021
En Île-de-France, l’hôtel social est souvent mobilisé par les associations pour héberger des familles, principalement migrantes et accompagnées d’enfants de moins de 6 ans. À cet âge, l’enfant nécessite un suivi de soins régulier auprès des professionnels pédiatriques. Nous supposons que ce suivi est dépendant de la mobilité résidentielle inhérente au système d’hébergement hôtelier. Cet article a pour objectif de reconstituer le parcours résidentiel des familles et le parcours de soins de leurs enfants et de saisir comment ces derniers s’influencent. La démonstration repose sur 18 entretiens biographiques spatialisés réalisés entre 2013 et 2016 auprès des familles sans logement hébergées en…
Political community resilience in declining rural areas in Finland
2021
Abstract In this article, we study how declining rural communities build political resilience in Finland. Community resilience is an adaptive process through which rural communities try to maintain their viability in changed circumstances. This process does not entail a submissive attitude, but rather active agency and an effort to influence matters concerning the community’s well-being. We focus on the political dimension of resilience by identifying different local tactics that rural communities adopt to promote their own development following municipal mergers. We classify these tactics into three categories: cooperation, conflict and community-led development. The significant difference…
LA RESPONSABILITÀ DIRIGENZIALE TRASFIGURATA E LA DISCIPLINA DELLE REGIONI SPECIALI
2019
La responsabilità dirigenziale nell’ordinamento del pubblico impiego delle Regioni speciali ricalca sostanzialmente la disciplina statale, in linea con la tendenza c.d. centralista che ha progressivamente attratto a livello statale la disciplina del pubblico impiego di tali Regioni nel presupposto dell’esclusiva competenza del legislatore statale del trattamento giuridico ed economico dei dipendenti regionali
INSTITUTIONALISATION OF RETURN MIGRATION IN LATVIA: THE CASE OF REGIONAL COORDINATORS
2021
Emigration countries such as Latvia institutionally should address the negative consequences of the ageing populations' economic and demographic challenges. To this aim, in 2018 network of five regional return migration coordinators was established to foster and nationally encourage return migration. The primary function of the regional coordinator is to foster and facilitate requests of potential return migrants.Drawing on interview materials collected in 2020 with return migration coordinators at the regional level – Latgale, Vidzeme, Zemgale, Kurzeme and Riga, we illustrate good-practice of return migration institutionalisation in Latvia.Our study focuses on three main fields of interest…
The Effects of Revitalizing Actions – Identification and Significance for the Development Policy of a Region (a Case Study of Opolskie Voivodeship)
2016
The aim of the work is to identify effects of the process of revitalization in the space of a region. The authors examine the results which were achieved on closing the realization of revitalization projects in the years 2007-2013 in Opolskie Voivodeship. They also undertake an attempt to determine their significance for the perspective shaping of the regional development policy. The research was conducted on the basis of the analyses of: applications of revitalization projects co-financed within the Regional Operation Program for Opolskie Voivodeship in the years 2007-2013, local revitalization programs in the cities of Opolskie Voivodeship, focus studies conducted in 12 cities of the regi…
Działania rewitalizacyjne w polityce rozwoju lokalnego i regionalnego
2016
Celem artykułu jest identyfikacja i ocena uwarunkowań oraz znaczenia rewitalizacji w polityce rozwoju. Badania przeprowadzono na przykładzie działań rewitalizacyjnych podejmowanych w województwie opolskim w latach 2007–2013. Opierały się one na analizie projektów rewitalizacyjnych wykonanych w ramach działań 6.1 i 6.2 RPO WO 2007–2013. Analiza ta została wykonana na podstawie: weryfikacji dokumentacji dotyczącej przedmiotowych inicjatyw rewitalizacyjnych, badań fokusowych z przedstawicielami władz oraz mieszkańcami miast, w których realizowano projekty, badań ankietowych z przedstawicielami wszystkich JST w województwie opolskim. Dodatkowo zastosowano metodę desk research, pozwalającą na id…
Māsu noslodze reģionālās slimnīcas ķirurģijas-traumatoloģijas nodaļā
2018
Bakalaura darba tēma - ’’Māsu noslodze reģionālās slimnīcas ķirurģijas – traumatoloģijas nodaļā’’. Tēmas aktualitāti nosaka pieaugošais cilvēkresursu trūkums veselības aprūpē, kā rezultātā palielinās māsu noslodze - nepieciešamais laika apjoms konkrētu darbību un pienākumu veikšanai. Nesamērīgas noslodzes rezultātā tiek negatīvi ietekmēta visa veselības aprūpes sistēma. Pētījuma mērķis ir noskaidrot māsu noslodzi reģionālās slimnīcas ķirurģijas – traumatoloģijas nodaļā. Pētījuma uzdevumi ir literatūras avotu izpēte, novērojuma protokola un anketas izstrāde, kā arī to analīze. Pētījums veikts reģionālās slimnīcas ķirurģijas – traumatoloģijas nodaļā, iekļaujot 10 respondentus – visas dotajā m…
Inhibition of small G proteins of the Rho family by statins orClostridium difficiletoxin B enhances cytokine-mediated induction of NO synthase II
2000
In order to investigate the involvement of Ras and/or Rho proteins in the induction of the inducible isoform of nitric oxide synthase (NOS II) we used HMG-CoA reductase inhibitors (statins) and Clostridium difficile toxin B (TcdB) as pharmacological tools. Statins indirectly inhibit small G proteins by preventing their essential farnesylation (Ras) and/or geranylgeranylation (Rho). In contrast, TcdB is a glucosyltransferase and inactivates Rho-proteins directly. Human A549/8- and DLD-1 cells as well as murine 3T3 fibroblasts were preincubated for 18 h with statins (1–100 μM) or TcdB (0.01–10 ng ml−1). Then NOS II expression was induced by cytokines. NOS II mRNA was measured after 4–8 h by R…
A novel microtubule de-stabilizing complementarity-determining region C36L1 peptide displays antitumor activity against melanoma in vitro and in vivo
2015
AbstractShort peptide sequences from complementarity-determining regions (CDRs) of different immunoglobulins may exert anti-infective, immunomodulatory and antitumor activities regardless of the specificity of the original monoclonal antibody (mAb). In this sense, they resemble early molecules of innate immunity. C36L1 was identified as a bioactive light-chain CDR1 peptide by screening 19 conserved CDR sequences targeting murine B16F10-Nex2 melanoma. The 17-amino acid peptide is readily taken up by melanoma cells and acts on microtubules causing depolymerization, stress of the endoplasmic reticulum and intrinsic apoptosis. At low concentrations, C36L1 inhibited migration, invasion and proli…
Autonomia regionale e riforme costituzionali nella transizione del sistema politico italiano
2016
A partire dalla crisi della "Prima Repubblica", dai primi anni Novanta ad oggi, il sistema politico italiano è entrato in una lunga fase di transizione che non è ancora approdata a un nuovo assetto istituzionale e costituzionale stabile. I cambiamenti, o i tentativi di cambiamento, del sistema elettorale e partitico, del sistema di governo e del sistema statale hanno prodotto alcune parziali riforme costituzionali e varie riforme elettorali, spesso tra loro contraddittorie, ispirate, di volta in volta, da maggioranze politiche contingenti e ristrette. È in questo quadro generale che il saggio colloca l'analisi dell'autonomia regionale in Italia, per comprendere i fattori che ne spiegano l’e…