Search results for "REGION"
showing 10 items of 4910 documents
Sporadic ALS is not associated with VAPB gene mutations in Southern Italy
2006
Abstract Mutations in the Cu/Zn superoxide dismutase (Sod1) gene have been reported to cause adult-onset autosomal dominant Amyotrophic Lateral Sclerosis (FALS). In sporadic cases (SALS) de novo mutations in the Sod1 gene have occasionally been observed. The recent finding of a mutation in the VAMP/synaptobrevin-associated membrane protein B (VAPB) gene as the cause of amyotrophic lateral sclerosis (ALS8), prompted us to investigate the entire coding region of this gene in SALS patients. One hundred twenty-five unrelated patients with adult-onset ALS and 150 healthy sex-age-matched subjects with the same genetic background were analyzed. Genetic analysis for all exons of the VAPB gene by DH…
Rare sacral space-occupying lesions, their surgical management and reconstructive measures involved
1988
Nine cases of space-occupying lesions of the sacral bone are presented. The problems of the clinical diagnosis, which in many cases comes too late, are discussed together with the indications for surgical treatment in this special group of tumours. The main clues are provided by the changes in the X-rays as well as the more modern imaging techniques (CT and MRI). The surgical technique aims at a most radical tumour removal with preservation of the sacral nerve roots, after which stabilisation of the sometimes weakened pelvic girdle may be necessary. The good prospects of complete removal of these tumours of the sacrum with satisfactory results seem to be very little known and justifies furt…
Recovery of hormonal, blood lipid, and hematological profiles from a North Pole expedition.
2011
INTRODUCTION This study examined the recovery patterns of hormonal, blood lipid, and hematological profiles following strenuous physical loading, continuous extreme cold exposure and energy deficit induced by a North Pole expedition. METHODS Seven men completed an 850-km North Pole expedition in temperatures varying from -3 degrees C to -47 degrees C. Daily energy intake was approximately 23 MJ x d(-1) and was composed of approximately 60% fat. Blood samples were collected 2 wk before (Pre) the expedition and after 2 wk (Post 1), and 2 mo (Post 2). Additional samples were collected on the first (R1), third (R3), and fifth (R5) return days. RESULTS Mean weight loss upon return was 10 kg. Ene…
Oral lichenoid lesions associated with amalgam restorations : a prospective pilot study addressing the adult population of the Basque Country
2011
Oral lichenoid lesions (OLLs) are linked to a heterogeneous group of pathologies involving the oral mucosa that cannot be distinguished from the oral lichen planus excepting the fact that direct causal factors such as silver amalgam restorations (SARs) can be allocated to them. Purpose: To analyze the prevalence of mucosal lesions associated with SAR in a group of SAR carrying patients in the Basque Country. Study D esign: A clinical prospective study was carried out on 100 adult patients over 30 years of age at the UPV/ EHU Clinical Odontology Service whose rear teeth had at least one SAR. Patients were identified and mucosal lesions and amalgam restorations were characterized. Patch tests…
Evidence for early activation of primary motor cortex and SMA after electrical lower limb stimulation using EEG source reconstruction
2006
Compared to median nerve somatosensory evoked potentials (SEP), less is known about activity evoked by nerve stimulation of the lower limb. To understand the mechanisms and the physiology of sensor- and motor control it is useful to investigate the sensorimotor functions as revealed by a standardized functional status. Therefore, we investigated SEPs of the lower limb in 6 healthy male volunteers. For each side, tibial and peroneal nerves were stimulated transcutaneously at the fossa poplitea. The tibial nerves were also stimulated further distally at the ankle joint. Source localization was applied to 64-EEG-channel data of the SEPs. In contrast to somatosensory areas, which are activated …
FAIR and dynamic susceptibility contrast-enhanced perfusion imaging in healthy subjects and stroke patients.
2002
Purpose To compare dynamic susceptibility contrast-enhanced magnetic resonance imaging (DSC-MRI) and the flow-sensitive alternating inversion recovery (FAIR) technique for measuring brain perfusion. Materials and Methods We investigated 12 patients with acute stroke, and 10 healthy volunteers with FAIR and DSC maps of regional cerebral blood volume (rCBV), mean transit time (MTT), and regional cerebral blood flow (rCBF). Results In volunteers good gray/white-matter contrast was observed in FAIR, rCBF, and rCBV maps. Regions with high signal intensities in FAIR matched well with high values of rCBV and rCBF. In ischemic stroke patients a high correlation (r = 0.78) of the ipsi- to contralate…
Topical prazosin attenuates sensitivity to tactile stimuli in patients with complex regional pain syndrome
2015
Background The sympathetic nervous system may play an important role in certain forms of chronic pain. The main aim of this study was to determine whether functional blockade of α1-adrenoceptors would alter sensitivity to cutaneous stimulation in patients with complex regional pain syndrome (CRPS). Methods and Results In an initial study, high-performance liquid chromatography-mass spectrometry of intradermal interstitial fluid collected from the forearms of three healthy individuals established that the α1-adrenoceptor antagonist prazosin penetrated the skin barrier when mixed in Lipoderm® cream base. Next, we found that application of this cream to the forearm of 10 healthy participants a…
Mental load during cognitive performance in complex regional pain syndrome I.
2018
Background Complex regional pain syndrome (CRPS) is associated with deficits in limb recognition. The purpose of our study was to determine whether mental load during this task affected performance, sympathetic nervous system activity or pain in CRPS patients. Methods We investigated twenty CRPS‐I patients with pain in the upper extremity and twenty age‐ and sex‐matched healthy controls. Each participant completed a limb recognition task. To experimentally manipulate mental load, the presentation time for each picture varied from 2 s (greatest mental load), 4, 6 to 10 s (least mental load). Before and after each run, pain intensity was assessed. Skin conductance was recorded continuously. R…
Does a Mental Training Session Induce Neuromuscular Fatigue?
2014
ROZAND, V., F. LEBON, C. PAPAXANTHIS, and R. LEPERS. Does a Mental Training Session Induce Neuromuscular Fatigue? Med. Sci. Sports Exerc., Vol. 46, No. 10, pp. 1981–1989, 2014. Mental training, as physical training, enhances muscle strength. Whereas the repetition of maximal voluntary contractions (MVC) induces neuromuscular fatigue, the effect of maximal imagined contractions (MIC) on neuromuscular fatigue remains unknown. Here, we investigated neuromuscular alterations after a mental training session including MIC, a physical training session including MVC, and a combined training session including both MIC and MVC of the elbow flexor muscles. Methods: Ten participants performed 80 MIC (d…
ReMindCare App for Early Psychosis: Pragmatic Real World Intervention and Usability Study
2020
[EN] Background: eHealth interventions are widely used in clinical trials and increasingly in care settings as well; however, their efficacy in real-world contexts remains unknown. ReMindCare is a smartphone app that has been systematically implemented in a first episode of psychosis program (FEPP) for patients with early psychosis since 2018. Objective: The objective of this study was to assess the efficacy of ReMindCare after 19 months of use in the clinic and varying use by individual patients. Methods: The integration of the ReMindCare app into the FEPP started in October 2018. Patients with early psychosis self-selected to the app (ReMindCare group) or treatment as usual (TAU group). T…