Search results for "REGION"

Neuronal Activity Drives Localized Blood-Brain-Barrier Transport of Serum Insulin-like Growth Factor-I into the CNS

2010

Upon entry into the central nervous system (CNS), serum insulin-like growth factor-1 (IGF-I) modulates neuronal growth, survival, and excitability. Yet mechanisms that trigger IGF-I entry across the blood-brain barrier remain unclear. We show that neuronal activity elicited by electrical, sensory, or behavioral stimulation increases IGF-I input in activated regions. Entrance of serum IGF-I is triggered by diffusible messengers (i.e., ATP, arachidonic acid derivatives) released during neurovascular coupling. These messengers stimulate matrix metalloproteinase-9, leading to cleavage of the IGF binding protein-3 (IGFBP-3). Cleavage of IGFBP-3 allows the passage of serum IGF-I into the CNS thro…

Two Enhancers Control Transcription of Drosophila muscleblind in the Embryonic Somatic Musculature and in the Central Nervous System

2014

The phylogenetically conserved family of Muscleblind proteins are RNA-binding factors involved in a variety of gene expression processes including alternative splicing regulation, RNA stability and subcellular localization, and miRNA biogenesis, which typically contribute to cell-type specific differentiation. In humans, sequestration of Muscleblind-like proteins MBNL1 and MBNL2 has been implicated in degenerative disorders, particularly expansion diseases such as myotonic dystrophy type 1 and 2. Drosophila muscleblind was previously shown to be expressed in embryonic somatic and visceral muscle subtypes, and in the central nervous system, and to depend on Mef2 for transcriptional activatio…

Nitrergic modulation of gastrointestinal function during early endotoxemia.

2006

After bacterial infection, the host reacts by signalling to the central nervous system where a cascade of physiologic, neuroendocrine and behavioural processes is orchestrated, collectively termed the acute phase response. Endotoxemia following Gram-negative bacterial infection induces a wide array of effects, including fever, loss of appetite and changes in gastrointestinal function that attempt to eliminate the challenge and restore homeostasis. Systemic administration of low doses of endotoxin (5-40 microg/kg) to rats is associated with changes in gastrointestinal motor function, inhibition of gastric acid secretion and increase in the gastric mucosal resistance to damage. These changes …

High-order services and spatial change in the central and eastern European countries

2004

This paper examines the level of high-order services in the CEECs. These services are of growing strategic importance across the whole range of production sectors in developed economies (Bailly and Coffey, 1994). They are both the cause and the consequence of globalization, in a cumulative process. It is through high-order services that large cities, and the regions around them, become closely interconnected within global networks. These services are fundamental features both in the changing pattern of regional disparities across an enlarged EU and in the process of metropolization (Bourdeau-Lepage, 2004a and Bourdeau-Lepage Huriot, 2002 and 2004). The development of high-order services wil…

Complex regional pain syndrome–up-to-date

2017

The pathophysiology of complex regional pain syndromes includes inflammation and central reorganisation. The treatment should be adjusted to the prevailing pathophysiology including possible psychosocial factors.

Reference schemes for e-government strategies. The analysis of the case regional government of valencia

2004

E-Government seems to be a fashionable topic and many interests have appeared around it, in particular since 1999. ICT industries, consultancy companies, supranational organizations and even research community are developing important activities with a clear consequence, among others, of increasing the self-convincement level about the importance of the topics. We analyze the experience on e-Government of the Region of Valencia in Spain, its boundary conditions, it background, its main achievement and frustrations, the next steps, the future plans in its, already, long road toward the modernization of its activities using the Information and Communication Technologies. In order to clarify o…

The resilience of Finnish farms: Exploring the interplay between agency and structure

2020

Resilience implies, in its essence, the capacity of a system to tolerate disturbances while retaining its essential functions. In the context of agriculture, resilience thinking calls for considering the ability of farms to thrive in turbulent times along with the ability of the ecological system – in which the agricultural production is embedded – to retain its function and integrity. Resilience is a relevant conceptual tool to analyse the contradictory management demands that farms are facing within the current neoliberal market regime: being economically viable and environmentally sustainable. In this study, the resilience of farms was operationalised through farmers' perceptions concern…

Centralismo y autonomía en los sistemas educativos hispanos (1813-1857)

1977

L'intervento nei centri storici: uno sguardo al quadro normativo

2022

Il contributo, ripercorrendo la produzione legislativa emanata sul tema dell’intervento nei centri storici dalla Regione Siciliana dagli anni Settanta ad oggi, si sofferma in particolare sulla LR 13/2015 “Norme per favorire il recupero del patrimonio edilizio di base dei centri storici”, un provvedimento legislativo molto contestato in ambito accademico che, di fatto, costituisce un grave arretramento culturale e tecnico non tenendo in alcun conto gli avanzamenti metodologici sul tema dei centri storici a partire dalla Carta di Gubbio del 1960. Nell’intento di favorire il recupero dei centri storici, la legge si fa portatrice di una serie di semplificazioni, a partire dal ricorso a classifi…

Full maxillary rehabilitation with an all-ceramic system

2009

With the appearance of all-ceramic systems, providing a choice of framework porcelains and allowing the same material to be used for the veneer, it is now possible to select the ideal structure in terms of both function and esthetics. Silicate ceramics allow porcelain laminate veneers and crowns to be used in the anterior region, providing excellent esthetics; while for the posterior area, where function takes precedence, oxide ceramics, specifically zirconium oxide, are preferred. The IPS e.max ceramic system, heir apparent to the IPS Empress 2 system, combines the advantages of zirconium oxide ceramics (IPS e.max Zircad) with the excellent esthetic qualities of silicate ceramics (IPS e.ma…