Search results for "REGIONS"

showing 10 items of 1521 documents

Cloning and characterization of the promoter of Hugl-2, the human homologue of Drosophila lethal giant larvae (lgl) polarity gene.

2007

The human lgl gene, Hugl-2 (llgl2, Lgl2), codes for a cytoskeletal protein involved in regulating cell polarity. Here, we report the identification and functional characterization of the promoter region ( approximately 1.2kb) of the Hugl-2 gene. Luciferase expression assays show a high basal Hugl-2 promoter activity in different cell lines and primary human hepatocytes. Truncations of the promoter identified a GC-rich region important for this activity. Alignment of human and mouse genomic sequences demonstrate that this is an evolutionary conserved region fcontaining putative binding sites for several transcription factors including Elk-1 and Sp-1. Mithramycin A reduces Hugl-2 expression i…

Sp1 Transcription FactorMolecular Sequence DataBiophysicsDown-RegulationGenes InsectBiologyBiochemistryCell LineDownregulation and upregulationEpidermal growth factorCell polarityChlorocebus aethiopsAnimalsDrosophila ProteinsHumansLuciferaseCloning MolecularPromoter Regions GeneticMolecular BiologyGeneTranscription factorBase PairingBase SequenceEpidermal Growth FactorSequence Homology Amino AcidTumor Suppressor ProteinsCell PolarityPromoterCell BiologyMolecular biologyCytoskeletal ProteinsDrosophila melanogasterCell cultureCOS CellsSequence AlignmentBiochemical and biophysical research communications
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Effect of a common exercise programme with an individualised progression criterion based on the measurement of neuromuscular capacity versus current …

2021

IntroductionHigh-load resistance training has shown positive effects in pain and function in lower limb tendinopathies. However, some authors suggest that current exercise programmes produce an increase in tolerance to load and exercise in general but without fixing some existing issues in tendinopathy. This may indicate the need to include training aspects not currently taken into account in the current programmes. The main objective of this study will be to compare the effect of a common exercise protocol for the three predominant lower limb tendinopathies (Achilles, patellar and gluteal), based on an individualised control of the dose and training of specific aspects of the neuromuscular…

Sports medicinehipFerides i lesions Tractamentknee:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Quality of lifeInformed consent:Anatomy::Body Regions::Extremities::Lower Extremity [Medical Subject Headings]:Anatomy::Musculoskeletal System::Tendons::Achilles Tendon [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Rehabilitation::Exercise Therapy [Medical Subject Headings]1506Randomized Controlled Trials as Topic:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Clinical Trials as Topic::Controlled Clinical Trials as Topic::Randomized Controlled Trials as Topic [Medical Subject Headings]foot & ankleMedicina física y rehabilitaciónRrehabilitation medicineGeneral MedicineExercise TherapyTreatment OutcomeLower Extremity:Anthropology Education Sociology and Social Phenomena::Social Sciences::Quality of Life [Medical Subject Headings]MedicineRodillamedicine.medical_specialtyBest practiceCaderaRehabilitation MedicineIntervention (counseling)medicineHumans1727:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome [Medical Subject Headings]Protocol (science)sports medicineFootbusiness.industryPieMedicina deportivamedicine.diseaseClinical trialTendinopathy:Diseases::Musculoskeletal Diseases::Muscular Diseases::Tendinopathy [Medical Subject Headings]Physical therapyQuality of LifeTobilloAnkleTendinopathyTendinitisbusiness
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Subcytocidal attack by staphylococcal alpha-toxin activates NF-kappaB and induces interleukin-8 production.

2001

ABSTRACTFormation of transmembrane pores by staphylococcal alpha-toxin can provoke a spectrum of events depending on target cell species and toxin dose, and in certain cases, repair of the lesions has been observed. Here, we report that transcriptional processes are activated as a response of cells to low toxin doses. Exposure of monocytic (THP-1) or epithelial (ECV304) cells to 40 to 160 ng/ml alpha-toxin provoked a drop in cellular ATP level that was followed by secretion of substantial amounts of interleukin-8 (IL-8). Cells transfected with constructs comprising the proximal IL-8 promoter fused to luciferase or to green fluorescent protein cDNA exhibited enhanced reporter gene expression…

StaphylococcusImmunologyBacterial ToxinsBiologymedicine.disease_causeMicrobiologyCell LineHemolysin ProteinsAdenosine TriphosphatemedicineHumansSecretionLuciferaseInterleukin 8Promoter Regions GeneticRegulation of gene expressionReporter geneCellular Microbiology: Pathogen-Host Cell Molecular InteractionsToxinInterleukin-8NF-kappa BTransfectionMolecular biologyInfectious DiseasesCell cultureParasitologyCaltech Library ServicesInfection and immunity
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Le trasformazioni dello Stato regionale: spunti per una ricerca

2022

The author studies the relationships between the State and the Regions

State RegionsSettore IUS/08 - Diritto Costituzionale
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The Psychological Science Accelerator’s COVID-19 rapid-response dataset

2023

Funder: Amazon Web Services (AWS) Imagine Grant

Statistics and Probability223 participants with varying completion rates. Participants completed the survey from 111 geopolitical regions in 44 unique languages/dialects. The anonymized dataset described here is provided in both raw and processed formats to facilitate re-use and further analyses. The dataset offers secondary analytic opportunities to explore copingBF Psychology230 Affective NeuroscienceHealth Behaviorand demographic information for each participant. Each participant started the study with the same general questions and then was randomized to complete either one longer experiment or two shorter experiments. Data were provided by 73Message framingDiseasesLibrary and Information Sciences:Ciências Sociais::Psicologia [Domínio/Área Científica]geographical and cultural context characterizationHV Social pathology. Social and public welfare. CriminologypandemiatEducationa general questionnaire examining health prevention behaviors and COVID-19 experienceddc:150SDG 3 - Good Health and Well-beingRA0421 Public health. Hygiene. Preventive MedicineSurveys and QuestionnairesAdaptation PsychologicalyleiskartoituksetHumansPendienteHealth behaviorsPandemicsframingBehaviour Change and Well-beingEmotion regulationSelf-determination messagingand self-determination across a diverseCOVID-19kansainvälinen vertailuResearch dataComputer Science Applicationswhich can be merged with other time-sampled or geographic data.cognitive reappraisalsglobal sample obtained at the onset of the COVID-19 pandemicterveyskäyttäytyminenIn response to the COVID-19 pandemic/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingand autonomy framing manipulations on behavioral intentions and affective measures. The data collected (April to October 2020) included specific measures for each experimental studyStatistics Probability and UncertaintyPeople’s healthtutkimusaineistosurvey-tutkimusDatasetInformation Systemsthe Psychological Science Accelerator coordinated three large-scale psychological studies to examine the effects of loss-gain framing
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Social capital and economic growth in Europe: nonlinear trends and heterogeneous regional effects

2016

After two decades of academic debate on the social capital-growth nexus, discussion still remains open. Most of the literature so far, however, has followed the one-size-its-all approach, neglecting that the great disparities across geographical units might have implications in this relationship. This article analyzes the role of two social capital indicators on the growth of 237 European regions in the period 1995–2007 by implementing a set of both parametric and non- parametric regressions. Whereas the former impose a linear functional form for the parameters, the latter relax this assumption providing a flexible frame in which the functional form is given by the data. The technique also …

Statistics and ProbabilityMacroeconomicsEconomics and Econometricsjel:Z1305 social sciencesSocialist mode of productionEconomic growth European regions nonparametric regression social capitalRegressionjel:C140502 economics and businessEconomics050207 economicsStatistics Probability and Uncertaintyjel:R11Nexus (standard)Social Sciences (miscellaneous)050205 econometrics Social capital
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Unusual binding ability of α,β-dehydrodipeptides towards metal ions

1994

Abstract Ni II , Zn II and Co II complexes of α,β-dehydro-dipeptides (containing Gly, Leu, Ala, Val or Phe residues) were studied by potentiometric and spectroscopic methods. Deprotonation and coordination of amide nitrogens occurred in all cases around the physiological pH range. The dipeptides with composition of Xaa-Δ-Ala formed octahedral species, while Gly-Δ-Xaa (Xaa = Leu or Phe) formed square planar bis complexes with Ni II .

StereochemistryMetal ions in aqueous solutionPotentiometric titrationbody regionsInorganic Chemistrychemistry.chemical_compoundBinding abilityDeprotonationTermészettudományokchemistryOctahedronAmideMaterials ChemistryPh rangePhysical and Theoretical ChemistryKémiai tudományokPolyhedron
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REGULATORY ELEMENTS OF THE LEUKAEMIA INHIBITORY FACTOR (LIF) PROMOTER IN MURINE BONE MARROW STROMAL CELLS

1999

Leukaemia inhibitory factor (LIF) plays an important role as a haematopoietically active cytokine. As described earlier in a murine model, interleukin 1 (IL-1) induced LIF mRNA and protein expression. We utilized the murine cell line +/+-1.LDA11 to further define regulatory mechanisms of LIF expression in bone marrow stromal cells. The production of LIF mRNA is stimulated by IL-1beta, TNF-alpha, and the cAMP analogue 8-bromoadenosine 3':5'-monophosphate (8BrcAMP). LIF mRNA expression is controlled at the transcriptional level. Different fragments from -542 to -45 bp 5' upstream of the transcriptional start site of the murine LIF gene were fused to the luciferase gene. All LIF-promoter lucif…

Stromal cellRecombinant Fusion Proteinsmedicine.medical_treatmentImmunology8-Bromo Cyclic Adenosine MonophosphateBone Marrow CellsStimulationRegulatory Sequences Nucleic AcidBiologyLeukemia Inhibitory FactorBiochemistryMiceGenes ReportermedicineAnimalsHumansImmunology and AllergyLuciferaseRNA MessengerNuclear proteinPromoter Regions GeneticMolecular BiologyCells CulturedLymphokinesMessenger RNAInterleukin-6Tumor Necrosis Factor-alphaInterleukinHematologyMolecular biologyGrowth InhibitorsRecombinant ProteinsCytokinemedicine.anatomical_structureGene Expression RegulationBone marrowStromal CellsInterleukin-1Cytokine
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Interplay of three G‑quadruplex units in the KIT promoter

2019

The proto-oncogene KIT encodes for a tyrosine kinase receptor, which is a clinically validated target for treating gastrointestinal stromal tumors. The KIT promoter contains a G-rich domain within a relatively long sequence potentially able to form three adjacent G-quadruplex (G4) units, namely, K2, SP, and K1. These G4 domains have been studied mainly as single quadruplex units derived from short truncated sequences and are currently considered promising targets for anticancer drugs, alternatively to the encoded protein. Nevertheless, the information reported so far does not contemplate the interplay between those neighboring G4s in the context of the whole promoter, possibly thwarting dru…

Stromal cellbiologyChemistryGeneral ChemistryG-quadruplexBiochemistryMolecular biologyProto-Oncogene MasCatalysisReceptor tyrosine kinaseG‐Quadruplex Multiple G4 cancerG-QuadruplexesProto-Oncogene Proteins c-kitColloid and Surface ChemistrySettore CHIM/03 - Chimica Generale E Inorganicabiology.proteinHumansPromoter Regions GeneticGene
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Regional heterogeneity in the business environment: the case of Italy

2022

How do we evaluate the business environment of regional economies? This paper makes use of primary data from the World Bank’s Subnational Doing Business studies to analyze the capacity of Italian regions to facilitate entrepre- neurs in setting up and operating new businesses. By comparing data across locations and over time, we are able to identify best practices that may help policy makers in the implementation of reforms aiming at improving the business environ- ment of Italian regions and, as a result, of the country.

Subnational Doing Business World Bank Regions Investments
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