Search results for "REGIONS"
showing 10 items of 1521 documents
The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane X receptor (PXR) and co…
2004
Induction of cytochrome P450 3A (CYP3A) by xenobiotics may lead to clinically relevant drug interactions. In contrast with other CYP3A family members, studies on the inducibility of CYP3A5 indicate conflicting results. We report the induction of CYP3A5 mRNA in 13 of 16 hepatocyte preparations exposed to rifampin. Furthermore, induction of CYP3A5 mRNA was observed in intestinal biopsies in three of eight probands following exposure to the antibiotic. The highest absolute levels of CYP3A5 transcripts were found following rifampin treatment in hepatocytes and intestines from carriers of CYP3A5*1 alleles. Elucidation of the mechanism involved in CYP3A5 induction revealed that constitutively act…
The yeast putative transcriptional repressor RGM1 is a proline-rich zinc finger protein.
1991
Abstract I have cloned a yeast gene, RGM1, which encodes a proline-rich zinc, finger protein. rgm1 mutants do not show any obvious phenotype but overexpression of RGM1 gene greatly impairs cell growth. The proline-rich region of RGM1 attached to a heterologous DNA binding domain is able to repress the expression of the target gene. RGM1 shares similar zinc finger motifs with the mammalian Egr (early growth response) proteins as well as proline-rich sequences with a high serine and threonine content, suggesting that RGM1 and Egr proteins could have functional similarities.
The polypyrimidine tract-binding protein (PTB) is involved in the post-transcriptional regulation of human inducible nitric oxide synthase expression.
2006
Human inducible nitric oxide synthase (iNOS) expression is regulated by transcriptional and post-transcriptional mechanisms. We have recently shown that the multifunctional RNA-binding proteins KH-type splicing regulatory protein and tristetraprolin are critically involved in the post-transcriptional regulation of human iNOS expression. Several reports have shown that KH-type splicing regulatory protein colocalizes with the polypyrimidine tract-binding protein (PTB), and both RNA-binding proteins seem to interact with the same mRNAs. Therefore we analyzed the involvement of PTB in human iNOS expression. In human DLD-1 cells, cytokine incubation necessary to induce iNOS expression did not ch…
Rethinking Regional Innovation Systems to capture regions’ variety
2014
Over the last few decades the concept of Regional Innovation Systems has given rise to a line of research which aims to highlight the functioning of network relationships and their importance in the innovation process at a meso-economic level. Despite limitations, this approach has thrown up some interesting reflections on the systemic nature of the process of innovation at regional level. It proposes some insights to draw an interpretive framework which includes elements for analysing disparate regions. The aim of this paper is to highlight the main aspects of the issue that might allow to go over in the debate opening up perspectives for analysing regional systems of innovation, both adva…
Economic Growth in the Regions of Europe, Sardadvar S. (2011), Berlin: Springer-Verlag.
2012
An ambitious endeavour to reconcile the faster empirical research with the slower theoretical modelling of regional growth and convergence is undertaken in this book by Sardadvar. To this end, the author introduces a spatial dependence component into the theoretical formulation of a neoclassical growth model and then provides an empirical application to European regions.
Valori comuni
2021
Il saggio analizza la possibilità da parte le Regioni italiane di avere obiettivi e finalità proprie secondo i propri Statuti e oltre la Costituzione italiana.
Development of Household Income Towards Modern Welfare Economics in Latvia
2020
Latvia in international comparisons is among the countries with rather low average income for households but rather high differences in income in households, especially in highest income households (richest quintile) characterised with significant indicators of variability in euro zone countries by Household and Consumption Survey conducted buy Bank of Latvia by methodology of European Central Bank in all eurozone countries and according EU- SILC (European Union Statistics on Income and Living Conditions) data. This current research is devoted to analysis of development of income and variability of income of households in Latvia in comparison with other OECD countries and eurozone countries…
Role of Education and Training on Income in Different Regions of Latvia
2019
Latvia is often critisised by international institutions on rising gap for income differences in several social groups. This current research is devoted to analyse of role of education and training on income level. Research methods used: scientific publications and previous conducted research analysis, analysis of EU-SILC data on differences in income depending from education level, from regions and from territory (urban/rural), interviews of regional authorities on life-long training arrangements and applications in regions with lower income level. Data analysis methods: descriptive statistics (indicators of central tendency or location, indicators of variability), cross-tabulations of hou…
Quitter sa région pour entrer à l'université
2006
This paper aims at understanding the regional mobility of new entrants to university. The regionalmobility is marginal. But, the impact of social and academic characteristics shows that selfselection processes exist. The combine effects of fields and regions impacts highlight the role ofavailability of university program on student choice.
Relationship between low Ankle-Brachial Index and rapid renal function decline in patients with atrial fibrillation: a prospective multicentre cohort…
2015
Objective: To investigate the relationship between Ankle-Brachial Index (ABI) and renal function progression in patients with atrial fibrillation (AF). Design: Observational prospective multicentre cohort study. Setting: Atherothrombosis Center of I Clinica Medica of 'Sapienza' University of Rome; Department of Medical and Surgical Sciences of University Magna Græcia of Catanzaro; Atrial Fibrillation Registry for Ankle-Brachial Index Prevalence Assessment-Collaborative Italian Study. Participants: 897 AF patients on treatment with vitamin K antagonists. Main outcome measures: The relationship between basal ABI and renal function progression, assessed by the estimated Glomerular Filtration R…