Search results for "RELATION"
showing 10 items of 10542 documents
Technostress and Social Networking Services: Uncovering Strains and Their Underlying Stressors
2017
Numerous users of social networking sites and services (SNS) suffer from technostress and its various strains that hinder well-being. Despite a growing research interest on technostress, the extant studies have not explained what kinds of various strains can SNS use create and how can these strains be traced back to different stressors. To address this gap in research, we employed a qualitative approach by narrative interviews. As a contribution, our findings introduce four SNS strains (concentration problems, sleep problems, identity problems, and social relation problems) and explain how they link with different underlying SNS stressors. As practical implications, the findings of this stu…
New 1,2,4-oxadiazole nortopsentin derivatives with cytotoxic activity
2019
New analogs of nortopsentin, a natural 2,4-bis(3&prime
Borexino’s search for low-energy neutrino and antineutrino signals correlated with gamma-ray bursts
2017
International audience; A search for neutrino and antineutrino events correlated with 2350 gamma-ray bursts (GRBs) is performed with Borexino data collected between December 2007 and November 2015. No statistically significant excess over background is observed. We look for electron antineutrinos ( ν¯e ) that inverse beta decay on protons with energies from 1.8 MeV to 15 MeV and set the best limit on the neutrino fluence from GRBs below 8 MeV. The signals from neutrinos and antineutrinos from GRBs that scatter on electrons are also searched for, a detection channel made possible by the particularly radio-pure scintillator of Borexino. We obtain currently the best limits on the neutrino f…
Dipeptides of S-Substituted Dehydrocysteine as Artzyme Building Blocks: Synthesis, Complexing Abilities and Antiproliferative Properties †
2021
Background: Dehydropeptides are analogs of peptides containing at least one conjugate double bond between α,β-carbon atoms. Its presence provides unique structural properties and reaction centre for chemical modification. In this study, the series of new class of dipeptides containing S-substituted dehydrocysteine with variety of heterocyclic moieties was prepared. The compounds were designed as the building blocks for the construction of artificial metalloenzymes (artzymes). Therefore, the complexing properties of representative compounds were also evaluated. Furthermore, the acknowledged biological activity of natural dehydropeptides was the reason to extend the study for antiproliferativ…
Synthesis and antiproliferative activity of the ring system [1,2]oxazolo[4,5-g]indole.
2012
Brand new ring: A series of 27 derivatives of the new ring system [1,2]oxazolo[4,5-g]indole were conveniently prepared and tested at the NCI for antiproliferative studies. Several of them showed good inhibitory activity toward all tested cell lines, reaching GI50 values generally at the micromolar and sub-micromolar levels and in some cases at nanomolar concentrations. The mean GI50 values, calculated on the full panel, were in the range 0.25-7.08 μM.
1-methil-3H-pyrazolo[1-2-a]benzo[1-2-3-4]tetrazin-3-ones, design synthesis and biological activity of new antitumoral agents
2005
1-Methylpyrazolo[1,2-a]benzo[1,2,3,4]tetrazin-3-ones 4, synthesized in good to excellent yields, were designed as novel alkylating agents because of their peculiar chemical behavior. All derivatives showed antiproliferative activity against more than 50 types of tumor cell lines with GI50 reaching sub-micromolar values. SAR studies revealed that the presence of a chlorine atom is well-tolerated in both positions 8 and 9, whereas in the case of the methyl group, switching from the 8 to the 9 position gives rise to the most active compound of the series, 4g, either for the number of cell lines inhibited and for selectivity against leukaemia and renal cancer subpanels. COMPARE and 3D-MIND comp…
3-(6-Phenylimidazo [2,1-
2019
A new series of imidazo[2,1-b][1,3,4]thiadiazole derivatives was efficiently synthesized and screened for their in vitro antiproliferative activity on a panel of pancreatic ductal adenocarcinoma (PDAC) cells, including SUIT-2, Capan-1 and Panc-1. Compounds 9c and 9l, showed relevant in vitro antiproliferative activity on all three pre-clinical models with half maximal inhibitory concentration (IC50) ranging from 5.11 to 10.8 µM, while the compounds 9e and 9n were active in at least one cell line. In addition, compound 9c significantly inhibited the migration rate of SUIT-2 and Capan-1 cells in the scratch wound-healing assay. In conclusion, our results will support further studies to increa…
Käsivedon muuttujien yhteys viidenkymmenen metrin vapaauinnin aikaan : uuden anturiteknologiaan perustuvan tehomittarin testaus
2017
Johdanto. Uimari on uidessaan käytännössä lähes koko vartalollaan kosketuksissa veteen. Vesi on väliaine, joka vastustaa uimarin etenemistä ja josta voiman ja vastavoiman periaatteen mukaisesti uimaria eteenpäin vievien voimien tukipinnat tulisi löytää. Veden viskoelastinen luonne luo omat erityispiirteensä eteenpäin suuntautuvien ja vastustavien voimien välille. Tässä tutkimuksessa keskitytään vapaauinnin käsivedon muuttujiin, joiden avulla pyritään arvioimaan uimarin käsivedon eteenpäin vieviä voimia ja niiden yhteyttä uintinopeuteen. Tämän lisäksi tutkitaan anturiteknologiaan perustuvan tehomittarin reliabiliteettia ja arvioidaan validiteettia. Menetelmät. Koehenkilöinä oli kansallisen j…
Comportamiento de las correlaciones producto-momento y tetracórica-policórica en escalas ordinales: un estudio de simulación
2017
El análisis estadístico multivariante de escalas de respuesta tipo Likert, dado su empleo generalizado, resulta un tema controvertido en la comunidad científica, principalmente desde la especificación del problema de la medida. Este trabajo tiene como objeto estudiar cómo afectan diversas condiciones de estas escalas ordinales al cálculo de los coeficientes de correlación producto-momento y tetracórico-policórico. Para ello, se aplica un estudio de simulación en el que se generaron 90 bases de datos con 10 ítems cada una, controlando las siguientes variables: número de categorías de respuesta, distribución simétrica o asimétrica de los datos, tamaño de la muestra y nivel de relación entre l…
Does Airbnb Disrupt the Private Rental Market? An Empirical Analysis for French Cities
2019
This article evaluates whether Airbnb rentals affect the rents in the private rental sector in eight cities in France. We estimate a hedonic equation for each city on individual data for apartments, allowing for heteroscedasticity and spatial error autocorrelation of unknown forms and using a large variety of structural and contextual characteristics of the apartments. We show that the density of Airbnb rentals puts upward pressure on rents in Lyon, Montpellier, and Paris, whereas it has no significant effect in other cities. If we restrict the analysis to the professional business of Airbnb rentals, which we define as the lodgings owned by an investor who rents either several “entire home…