Search results for "RELATION"
showing 10 items of 10542 documents
ARMONÍA DE PAREJA EN POBLACIÓN DE PERSONAS MAYORES: DIFERENCIAS ENTRE SEXOS
2016
El ajuste diádico no solamente es un factor esencial en la perdurabilidad y calidad de toda relación de pareja, sino que además, puede afectar a la vida personal y a la salud de sus miembros. El presente estudio explora el ajuste percibido por las personas mayores en España en su relación de pareja presente o pasada, analizando las posibles diferencias entre hombres y mujeres. Se administró la Escala de Ajuste Diádico a 80 personas entre los 51 y los 81 años. El 55% eran mujeres. El 66,3% estaban casados, el 21,3% separados o divorciados y un 12,5% había enviudado. Se tomó el valor 107 propuesto en la literatura como punto de corte para establecer un ajuste diádico positivo. La puntuación g…
Search for magnetically-induced signatures in the arrival directions of ultra-high-energy cosmic rays measured at the Pierre Auger Observatory
2020
We search for signals of magnetically-induced effects in the arrival directions of ultra-high-energy cosmic rays detected at the Pierre Auger Observatory. We apply two different methods. One is a search for sets of events that show a correlation between their arrival direction and the inverse of their energy, which would be expected if they come from the same point-like source, they have the same electric charge and their deflection is relatively small and coherent. We refer to these sets of events as "multiplets". The second method, called "thrust", is a principal axis analysis aimed to detect the elongated patterns in a region of interest. We study the sensitivity of both methods using a …
Revista complutense de educación
2020
Introducción: el desarrollo de las competencias en la educación obligatoria, concretamente las referidas al ámbito emocional, supone una oportunidad para integrar aquellos aprendizajes considerados imprescindibles. Los libros de texto constituyen el material pedagógico por excelencia, lo que permite atisbar los contenidos que se presentan en las aulas. El objetivo del trabajo fue evaluar el tratamiento de las competencias en salud mental y emocional en libros de texto de Ciencias Naturales de Educación Primaria en España. Metodología: la muestra quedó conformada por los textos de Educación Primaria de las tres editoriales de mayor distribución en España. Se realizó un análisis descriptivo d…
Linking employer branding orientation and firm performance: Testing a dual mediation route of recruitment efficiency and positive affective climate
2019
Faced with competitive labor markets, firms increasingly use employer branding to build a qualified workforce and engage their employees. However, our understanding of the impact of employer branding orientation on firm performance and the theoretical firm‐level mechanisms underlying this potential impact is very limited. To address this gap, we integrate brand marketing theory with human resource management (HRM) research to develop a model explicating how employer branding orientation is linked to firm performance through a dual route by enhancing both recruitment efficiency (i.e., external route: applicants) and positive affective climate (i.e., internal route: incumbent employees). The …
Changes in spatial and sectoral patterns of employment in Ile-de-France, 1978-1997
2006
International audience; This paper investigates the spatial distribution of employment in the region of Ile-de-France in 1978 and 1997. Exploratory spatial data analysis is used to identify employment centres and a sectoral analysis of the central business district (CBD) and sub-centres is performed. The results highlight a process of suburbanisation of employment in Ile-de-France between 1978 and 1997. A more polarised space emerges in 1997 than in 1978, with several employment centres specialised in different activities. Moreover, even if the spatial influence of the CBD declines over the study period, the CBD maintains its economic leadership by concentrating a large variety of high-orde…
Ochrona socjalna sędziów sądów powszechnych
2018
Stereoselective Synthesis and Pharmacological Evaluation of 2,4-Bridged Piperidine Derivatives Designed to Activate the κ-Opioid Receptor
2021
Retinoids as a Perspective in Treatment of Alzheimer’s Disease
2010
<i>Background:</i> In the past, we demonstrated that the disintegrin metalloproteinase ADAM10 has α-secretase activity in vitro and in cultured cells. We also found out that moderate overexpression of this proteinase inhibits Aβ peptide production and prevents the formation of amyloid plaques in an Alzheimer’s disease (AD) mouse model. Moreover, it corrects early hippocampal defects like LTP impairment and increases cortical synaptogenesis. <i>Objective:</i> Upregulation of ADAM10 might be an alternative approach concerning AD therapy. Our current research therefore focuses on substances and/or pathways which regulate ADAM10 gene expression. <i>Methods:</i&g…
The role of mitochondria in sterigmatocystin-induced apoptosis on SH-SY5Y cells
2020
Mitochondria are cellular organelles involved in many crucial functions, such as generation of energy (ATP) and initiation of apoptosis. The aim of the present study was to evaluate the role of mitochondria in the toxicity induced by sterigmatocystin (STE), a mycotoxin produced by fungi of the genus Aspergillus, on SH-SY5Y cells. Our results showed that STE exposure decreased cell viability in a time- and concentration-dependent manner by MTT assay and caused mitochondrial dysfunction, as highlighted by the increase of STE cytotoxicity in cells forced to rely on mitochondrial oxidative phosphorylation. Furthermore, intracellular ATP depletion and increased mitochondrial reactive oxygen spec…
Relaxation induced by N-terminal fragments of chromogranin A in mouse gastric preparations.
2007
Abstract A definitive role for chromogranin A (CGA)-derived fragments in the control of the gastrointestinal smooth muscle contractility has not been yet established. The purpose of the present study was to evaluate, in vitro , the effects of the recombinant vasostatin 1–78 (VS-1), CGA 7–57 and CGA 47–66 on the mouse gastric mechanical activity, recording the changes of intraluminal pressure. VS-1, CGA 7–57 and CGA 47–66 produced concentration-dependent relaxations. Mouse anti-vasostatin-1 monoclonal antibody 5A8, recognising the region 53–57, abolished the relaxation induced by VS-1, indicating the specificity of the effect. The relaxation was significantly reduced by tetrodotoxin (TTX), b…