Search results for "RELEASE"

Designing Medical Devices Based on Silicon Polymeric Material with Controlled Release of Local Anesthetics

2012

The drug delivery systems that are the object of this article take the form of a polymer matrix made of silicone containing a drug. These devices can be used as patches for local dermal applications releasing the drug in a controlled manner. The model active agent, lidocaine hydrochloride was chosen from the range of local anesthetics. When the drug is restricted to the surface, it is released more rapidly than when it is allowed to spread evenly throughout the silicon structure. When hydrophilic polymers such as PVA and HEC are mixed in with the lidocaine hydrochloride and deposited on the surface of the polymer matrix, we observed that the burst effect was eliminated without modifying the…

Increased Stability of Polysaccharide/Silica Hybrid Sub‐Millicarriers for Retarded Release of Hydrophilic Substances

2021

pH-sensitive hydrogel based on a novel photocross-linkable copolymer.

2004

A pH sensitive hydrogel has been prepared by a UV irradiation technique. Starting polymer was the PHM (poly hydroxyethylaspartamide methacrylated) obtained from polyaspartamide (PHEA) partially derivatized with methacrylic anhydride (MA). This new copolymer has been further derivatized with succinic anhydride (SA) to obtain PHM-SA that has been cross-linked by UV irradiation to form a pH sensitive hydrogel. The network, recovered after washing as a powder, has been been characterized by FT-IR spectrophotometry and particle size distribution analysis. Moreover, to have information about water affinity of the prepared sample, swelling measurements have been carried out in aqueous media mimick…

Environmentally sustainable production of cellulose-based superabsorbent hydrogels

2006

The development of new products and materials, especially those which are non-petrolchemical reserves and based on renewable organic resources, using innovative sustainable processes is nowadays of increasing interest and deserves the attention of both academic and industrial research. Cellulose and its derivatives, as renewable organic resources, have been used to synthesize novel superabsorbent hydrogels. Although the production of cellulose is one of the causes connected to deforestation, the production of suitably engineered cellulose superabsorbent hydrogel materials has been proposed to preserve water in typically arid areas in the world. Paradoxically, divinylsulfone (DVS), a small d…

Biocompatible Poly(N-isopropylacrylamide)-halloysite Nanotubes for Thermoresponsive Curcumin Release

2015

The grafting of poly(N-isopropylacrylamide) (PNIPAAM) onto the halloysite external surface is proposed in order to obtain a novel thermoresponsive drug carrier for curcumin delivery. The new nanomaterial is characterized by means of FT-IR spectroscopy, thermogravimetric analysis, and SEM investigations. A high density of polymer chain was achieved at the nanoparticle surface. The PNIPAAM dehydration phenomenon was observed in water above 32 °C that is nearly coincident with the lower critical solution temperature for the polymer. The colloidal stability as well as the wettability of the obtained nanomaterial may be triggered by temperature stimuli. In vitro tests simulating the gastro-intes…

Core‐shell nanoparticles with hyperbranched poly(arylene‐oxindole) interiors

2009

Opracowano synteze wysoce rozgalezionego poli(aryleno-oksyndolu) na drodze reakcji polimeryzacji pochodnej 5-bromoizatyny, a nastepnie modyfikacji terminalnych jednostek izatynowych. Tak przygotowany polimerowy rdzen, charakteryzujący sie stopniem rozgalezienia 100 %, byl substratem do rodnikowej polimeryzacji z przeniesieniem atomu (z ang. ATRP) w reakcji z akrylanem tert-butylu. Otrzymane kopolimery zawierające hydrofobowy rdzen i alkilowe lancuchy zakonczone wolnymi grupami karboksylowymi tworzą sferyczne nanocząstki. Przedstawiono wstepne wyniki badan dotyczących ich wlaściwości fizykochemicznych oraz potencjalnych zastosowan.

Depth profiling of Pu, 241Am and 137Cs in soils from southern Belarus measured by ICP-MS and alpha- and gamma-spectrometry

2003

The depth distribution of plutonium, americium, and Cs-137 originating front the 1986 accident at the Chernobyl Nuclear Power Plant (NPP) was investigated in several soil profiles in the vicinity from Belarus. The vertical migration of transuranic elements in soils typical of the 30 km relocation area around Chernobyl NPP was studied using inductively coupled plasma mass spectrometry (ICP-MS), alpha spectrometry, and gamma spectrometry. Transuranic concentrations in upper soil layers ranged from 6 x 10(-12) g g(-1) to 6 x 10(-10) g g(-1) for plutonium and from 1.8 x 10(-13) g g(-1) to 1.6 x 10(-11) g g(-1) for americium. These concentrations correspond to specific activities of Pu239+240 of…

Multisensory integration as a strategy to compensate for sodium and fat reduction in food

2012

Multisensory integration as a strategy to compensate for sodium and fat reduction in food. Forum Jeunes chercheurs

Managing Municipal Solid Waste: Energetic and Environmetal Comparison among different options

2001

Goal. This research aims to assess the environmental effects of integrated strategies in a municipal waste management system. In particular, analysis is focused on a waste stream in Palermo, where landfill involves the prompt disposal of the most waste after collection. The current local management system is compared with two integrated waste management alternatives. Both the options comply with Italian regulations, but each one predicts adopting the available technologies in different ways. Methods and objectives. Energetic and environmental balances are carried out in each management system referring to local waste composition in order to quantify energy consumption, the recovery of mater…

Incorporation of Pt(II) complex with [amino-2(methylthio)(1,2,4)triazole-(1,5-a)pyrimidine-6-carboxylic-acid] ligand in MCM41 for controlled release

2015

Drug carriers play a critical role for the loading and the release of the drug. A promising frontier is represented by a new class of innovative medicines that represents directional transport vehicles "drug delivery" and consist of assembled structures carrier (nano)-drug. Silica-based materials, nontoxic, biocompatible, have been used as adjuvant and excipient in pharmaceutical technology. In this class of compounds, the mesoporous materials, such as MCM41, SBA-15 and hexagonal mesoporous silica, have been investigated for medication and drug delivery due to their properties. In fact, these materials show a large specific pore volume made up of regular pores having a diameter in the nanom…