Search results for "REM"
showing 10 items of 11264 documents
Emmy Noether: a Portrait
2020
“I always went my own way in teaching and research,” Emmy Noether once wrote toward the end of her life.
Convergence of Measures
2020
One focus of probability theory is distributions that are the result of an interplay of a large number of random impacts. Often a useful approximation can be obtained by taking a limit of such distributions, for example, a limit where the number of impacts goes to infinity. With the Poisson distribution, we have encountered such a limit distribution that occurs as the number of very rare events when the number of possibilities goes to infinity (see Theorem 3.7). In many cases, it is necessary to rescale the original distributions in order to capture the behavior of the essential fluctuations, e.g., in the central limit theorem. While these theorems work with real random variables, we will a…
Emmy Noether’s Triumphal Years
2020
When Emmy Noether returned from the September 1929 conference in Prague – where she and Hasse surely spoke about their mutual mathematical interests – she belatedly answered a postcard he had sent here.
Generalized symmetries in nanostructure simulations
2009
Synchrotron x-ray transmission measurements and modeling of filters investigated for Athena
2020
International audience; Advanced Telescope for High-Energy Astrophysics is a large-class astrophysics space mission selected by the European Space Agency to study the theme "Hot and Energetic Universe." The mission essentially consists of a large effective area x-ray telescope and two detectors: the X-ray Integral Field Unit (X-IFU) and the Wide Field Imager (WFI). Both instruments require filters to shield from out-of-band radiation while providing high transparency to x-rays. The mission is presently in phase B; thus, to consolidate the preliminary design, investigated filter materials need to be properly characterized by experimental test campaigns. We report results from high-resolution…
COMPOSITE SYNERGY OF SERVICES - A NEW CONCEPT CONCERNING SERVICES
2013
The current paper addresses the dynamics of the service sector in Romania, from the perspective of a new concept, namely the "composite synergy of services". The main points of the paper approach the fact that direct and indirect investments in the service sector create a synergic and composite effect on the development of the economy, as a whole, in Romania. The paper aims to be a prequel to a mathematical and economic demonstration of the existence of the composite synergy of services, laying the theoretical foundations of the concept and underlining the premises for its existence.
Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: A pooled analysis of 1018…
2018
Background: Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the contributions of these two phenomena to the worldwide trends in the prevalence of raised blood pressure. Methods: We pooled 1018 population-based studies with blood pressure measurements on 88.6 million participants from 1985 to 2016. We first calculated mean systolic blood pressure (SBP), mean dia…
Occitanie, Haute-Garonne, Grenade, Le Castelet
2019
Le lieu-dit Le Castelet à Grenade (Haute-Garonne) est situé à égale distance (1,5 km) du confluent Hers-Girou vers l’est et d’un méandre de la Garonne vers le nord-ouest. Un projet de carrière de la Société Midi-Pyrénées Granulats a permis de retrouver dans ce lieu les traces de plusieurs occupations humaines, échelonnées pour l’essentiel entre le Néolithique moyen et de la fin de l’âge du Bronze. L’ancien réseau hydrographique secondaire de la Garonne marque le paysage et draine dans le sous-sol la nappe phréatique, constituant sans doute un atout. En effet, il suffit de creuser un puits au sein d’un paléo-chenal pour créer un point d’eau au milieu d’une plaine cultivable, et réunir ainsi …
Glosa do wyroku Sądu Najwyższego z dnia 9 lutego 2021 r., III KK 175/20
2022
W niniejszym opracowaniu autor akceptuje stanowisko Sądu Najwyższego, iż jeżeli w toku kontroli kasacyjnej Sąd Najwyższy stwierdzi, że apelacja strony, która wniosła kasację, nie została uwzględniona, a uzasadnienie wyroku sądu odwoławczego rażąco narusza przepis art. 457 § 3 k.p.k., zaś w kasacji w oparciu o „jakość” tego uzasadnienia wywodzony jest zarzut rażącego naruszenia art. 433 § 2 k.p.k. wprost (w treści zarzutu) lub też w uzasadnieniu kasacji (art. 526 § 1 k.p.k. w związku z art. 118 § 1 k.p.k.), to uchybienie takie wymaga uchylenia wyroku sądu odwoławczego, albowiem wymaga tego konstytucyjny art. 45 ust. 1 w zw. z art. 176 § 1 Konstytucji RP i konwencyjny (art. 6 EKPCz) standard …
Dexamethasone premedication suppresses vaccine-induced immune responses against cancer
2020
ABSTRACT Glucocorticosteroids (GCS) have an established role in oncology and are administered to cancer patients in routine clinical care and in drug development trials as co-medication. Given their strong immune-suppressive activity, GCS may interfere with immune-oncology drugs. We are developing a therapeutic cancer vaccine, which is based on a liposomal formulation of tumor-antigen encoding RNA (RNA-LPX) and induces a strong T-cell response both in mice as well as in humans. In this study, we investigated in vivo in mice and in human PBMCs the effect of the commonly used long-acting GCS Dexamethasone (Dexa) on the efficacy of this vaccine format, with a particular focus on antigen-specif…