Search results for "REORGANIZATION"

2018

Maturation and aging are important life periods that are linked to drastic brain reorganization processes which are essential for mental health. However, the development of generalized theories for delimiting physiological and pathological brain remodeling through life periods linked to healthy states and resilience on one side or mental dysfunction on the other remains a challenge. Furthermore, important processes of preservation and compensation of brain function occur continuously in the cerebral brain networks and drive physiological responses to life events. Here, we review research on brain reorganization processes across the lifespan, demonstrating brain circuits remodeling at the st…

Characterization of the consistent completion of analytic hierarchy process comparison matrices using graph theory

2019

Decision-making is frequently affected by uncertainty and/or incomplete information, which turn decision-making into a complex task. It is often the case that some of the actors involved in decision-making are not sufficiently familiar with all of the issues to make the appropriate decisions. In this paper, we are concerned about missing information. Specifically, we deal with the problem of consistently completing an analytic hierarchy process comparison matrix and make use of graph theory to characterize such a completion. The characterization includes the degree of freedom of the set of solutions and a linear manifold and, in particular, characterizes the uniqueness of the solution, a re…

cIAP1 regulates TNF-mediated cdc42 activation and filopodia formation

2013

International audience; umour necrosis factor-α (TNF) is a cytokine endowed with multiple functions, depending on the cellular and environmental context. TNF receptor engagement induces the formation of a multimolecular complex including the TNFR-associated factor TRAF2, the receptor-interaction protein kinase RIP1 and the cellular inhibitor of apoptosis cIAP1, the latter being essential for NF-κB activation. Here, we show that cIAP1 also regulates TNF-induced actin cytoskeleton reorganization through a cdc42-dependent, NF-κB-independent pathway. Deletion of cIAP1 prevents TNF-induced filopodia and cdc42 activation. The expression of cIAP1 or its E3-ubiquitin ligase-defective mutant restore…

Helix Inversion Controlled by Molecular Motors in Multistate Liquid Crystals.

2020

Unravelling the rules of molecular motion is a contemporary challenge that promises to support the development of responsive materials and is likely to enhance the understanding of functional motion. Advances in integrating light‐driven molecular motors in soft matter have led to the design and realization of chiral nematic (cholesteric) liquid crystals that can respond to light with modification of their helical pitch, and also with helix inversion. Under illumination, these chiral liquid crystals convert from one helical geometry to another. Here, a series of light‐driven molecular motors that feature a rich configurational landscape is presented, specifically which involves three stable …

Enthalpy/entropy compensation effects from cavity desolvation underpin broad ligand binding selectivity for rat odorant binding protein 3

2014

Evolution has produced proteins with exquisite ligand binding specificity, and manipulating this effect has been the basis for much of modern rational drug design. However, there are general classes of proteins with broader ligand selectivity linked to function, the origin of which is poorly understood. The odorant binding proteins (OBPs) sequester volatile molecules for transportation to the olfactory receptors. Rat OBP3, which we characterize by X-ray crystallography and NMR, binds a homologous series of aliphatic gamma-lactones within its aromatic-rich hydrophobic pocket with remarkably little variation in affinity but extensive enthalpy/entropy compensation effects. We show that the bin…

Analysis of the interventions aimed to help land property reorganization in the rural territory of Sicily over the 2001-2009 period

2013

Italian farming system has always been characterized by structural problems such as the small size of farms and the land property fragmentation. In order to remedy this pathological situation, ISMEA was commissioned to act as an intermediary between sellers and buyers and as an underwriter of compliance of the rules provided for by in force law. The objective of the present study is to analyse the effects of regulatory interventions aimed to help land property reorganization in Sicily - State Aid System no. 110/2001 and Community Tools - in order to reconstruct a general framework and to understand the actual extent and the respective effectiveness of these actions. On the whole 190 purchas…

Rappresentazioni e territorio nelle dinamiche del turismo: il caso della Lonely Planet Sicily

2018

L’attuale dibattito sul riordino territoriale del Paese rende nuovamente centrale il concetto di territorio che, da sempre, in una prospettiva geografica pone problemi definitori. Esso può essere, infatti, oggetto di produzioni simboliche e (ri)semantizzazioni in grado di ridefinirlo e di creare specifiche modalità di interazione. A questo proposito, il presente lavoro intende proporre una riflessione su alcune dinamiche di produzione e riproduzione simbolica che interessano il concetto di territorio nel turismo, ambito in cui si può osservare una relazione diretta tra rappresentazione del territorio (intesa anche come narrazione) e possibilità d’azione. In particolare, attraverso il caso s…

Tinnitus: a vision for research

2009

Tinnitus is classically defined as the perception of sound that has no external source. It was assumed to be primarily a disorder of the ear and has been linked to mechanisms equivalent to phantom pain; a pain sensation located to a no longer existing part of the body. Phantom pain is closely correlated with a cortical plasticity and with a reorganization of the somatosensory cortex. The end result is an alteration of neuronal activity, leading to tinnitus. Over the past decade, however, research on brain mechanisms of tinnitus has progressed rapidly, and insights have emerged into the possible neurological origins of tinnitus without any auditory dysfunction. Identification of the neurosci…

THE UNINTENDED PERVERTED EFFECTS OF THE RANKING OF UNIVERSITIES WITHIN THE POLITICAL ENVIRONMENTS WITHIN COUNTRIES IN TRANSITION. CASE STUDY: ROMANIA

2011

Ranking has arrived to be compulsory for all countries as a tool to compete in the global world. The ranking’s rules are settled by some couples of global rankers. When their practices are implemented into national environments, mainly in countries under transition, some perverted effects might appear. The paper focuses on effects on politic environments and their follow up on academic communities, students and parents, and civil society as an effect of mass media involvement. The theoretical issues are illustrated by the outcomes in Romania particularly as a consequence of the application of the Educational Law since January 2011.

CONSIDERATIONS CONCERNING THE REORGANIZATION OF A UNIVERSITY: LUCIAN BLAGA UNIVERSITY OF SIBIU

2011

The world is in crisis. The academic system, its core, too. It has to reorganise, to reform itself. Several steps were taken by developed countries but also the emerging ones or the new comers. In Romania, a new Education Low has settled a deep reform for universities. Observing the academic autonomy, each university has to find its new way according to the principles of the Education Low. Our case study refers on a middle seize university of regional vocation. The paper investigate the main factors to be considered on general context, national context and the university’s one in the process of reforming and restructuring the university.