Search results for "REPOSI"
showing 10 items of 158 documents
Exploring the SARS-CoV-2 Proteome in the Search of Potential Inhibitors via Structure-based Pharmacophore Modeling/Docking Approach
2020
To date, SARS-CoV-2 infectious disease, named COVID-19 by the World Health Organization (WHO) in February 2020, has caused millions of infections and hundreds of thousands of deaths. Despite the scientific community efforts, there are currently no approved therapies for treating this coronavirus infection. The process of new drug development is expensive and time-consuming, so that drug repurposing may be the ideal solution to fight the pandemic. In this paper, we selected the proteins encoded by SARS-CoV-2 and using homology modeling we identified the high-quality model of proteins. A structure-based pharmacophore modeling study was performed to identify the pharmacophore features for each…
New geo-portal for MODIS/SEVIRI image products with geolocation-based retrieval functionality
2015
A large number of remote sensing data sets have been collected in recent years by Earth observation instruments such as the moderate resolution imaging spectroradiometer (MODIS) aboard the Terra/Aqua satellite and the spinning enhanced visible and infrared imager (SEVIRI) aboard the geostationary platform Meteosat Second Generation. The advanced remote sensing products resulting from the analysis of these data are useful in a wide variety of appli- cations but require significant resources in terms of storage, retrieval, and analysis. Despite the wide availability of these MODIS/SEVIRI products, the data coming from these instruments are spread among different locations and retrieved from d…
Adverse Clinical Events and Mortality During Hospitalization and 3 Months After Discharge in Cognitively Impaired Elderly Patients
2012
BACKGROUND: Controversial findings are reported on hospital outcome in cognitively impaired patients. The aim of this study was to explore mortality risk according to cognitive status during hospitalization and after 3 months in elderly patients. METHODS: Sixty-six internal medicine and geriatric wards in Italy participated in the "Registry Politerapie SIMI (REPOSI)" during 2010. Of the 1,380 in-patients, aged 65 and older enrolled, 1,201 were included. Cognition was evaluated with the Short Blessed Test (SBT). Logistic regression was used to evaluate the association of questionable and impaired cognition (according to SBT cutoff points) with mortality during hospitalization and at follow-u…
Even a low-dose of moderate-to-vigorous physical activity reduces mortality by 22% in adults aged ≥60 years: a systematic review and meta-analysis
2015
Type de document : revue de littérature; International audience; Background The health benefits of 150 min a week of moderate-to-vigorous-intensity physical activity (MVPA) in older adults, as currently recommended, are well established, but the suggested dose in older adults is often not reached.Objectives We aimed to determine whether a lower dose of MVPA was effective in reducing mortality, in participants older than 60 years.Methods The PubMed and Embase databases were searched from inception to February 2015. Only prospective cohorts were included. Risk ratios of death were established into four doses based on weekly Metabolic Equivalent of Task (MET)-minutes, defined as inactive (refe…
The availability of raw data in substance abuse scientific journals
2018
[Objective]: The availability of research data sets is an important milestone since it can enhance the dynamics of research. This study aims to analyse the PubMed Central repository to determine the availability and type of raw data sets in Substance Abuse journals indexed in the Journal Citation Reports.
Rapporti di reggenza? Una descrizione ambivalente nella tradizione grammaticale tardoantica e medioevale
2023
This study aims to shed light on the historical development of a linguistic theory with reference to syntax in Late Antiquity and the Middle Ages, through an investigation of grammatical works related to Donatus, since a reflection on syntax emerges from the commentaries and from other grammatical works connected with his artes. This investigation focuses on the description of the government relation between praepositio and casus, through a preliminary collection of the occurrences of both terms with the Cross Database Searchtool of Brepols Publishers as a digital tool, and based on a textual analysis of the de praepositione sections included in a selection of grammatical works ranging from…
La qualità inclusiva della scuola: dalle pratiche didattiche al profilo del docente inclusivo
2018
L’attenzione della ricerca pedagogica e didattica si rivolge con sempre maggiore consapevolezza ai fattori chiave dei processi di inclusione: la formazione degli insegnanti, lo sviluppo ed il monitoraggio dei contesti educativi nonché la produzione e l’incremento di pratiche didattiche inclusive. Attraverso la ricerca si sono voluti mettere a fuoco tali fattori chiave con la redazione di appositi strumenti che ne permettessero il controllo e la valutazione. Questo lavoro documenta una ricerca della durata di tre anni che ha visto coinvolti docenti in servizio, docenti in formazione frequentanti il terzo anno del corso di Laurea in Scienze della Formazione Primaria e alunni della scuola pri…
QUALITÀ DELL’INCLUSIONE & INCLUSIONE DI QUALITÀ La formazione degli insegnanti e le strategie per promuovere la scuola inclusiva
Lo scenario internazionale si sta muovendo rapidamente verso la promozione di una scuola inclusiva. In Italia, questa realtà è affrontata da molti anni, ma le trasformazioni e il confronto internazionale hanno sollevato nuove domande e riflessioni critiche. In particolare l’attenzione oggi è posta su quello che, come affermato nel corso della Conferenza internazionale dell'UNESCO (2013), è considerato il fattore chiave dei processi di integrazione e di inclusione: la formazione degli insegnanti. L’attenzione della ricerca pedagogica viene posta sui fattori chiave dei processi di inclusione: la formazione degli insegnanti, lo sviluppo ed il monitoraggio dei contesti educativi nonché la …
"Tea for two": the Archive of the Italian Latinity of the Middle Ages meets the CLARIN infrastructure
2020
This paper aims at showing how integrating the Archive of the Italian Latinity of the Middle Ages (ALIM) into the ILC4CLARIN repository can provide mutual benefits. Making ALIM available to a large community of scholars and researchers, on the one side, represents the first step to reduce the lack of resources for Medieval Latin in CLARIN and, on the other side, constitutes an unprecedented contribution to not only linguistic investigations, but also to the studies of the culture and science at the basis of the Western European society. The paper describes the adopted approach aiming to keep intact the structure of the archive and its metadata, which are both accurately mirrored into the IL…
Contextual Metadata for Document Databases
2005
Metadata has always been an important means to support accessibility of information in document collections. Metadata can be, for example, bibliographic data manually created for each document at the time of document storage. The indexes created by Web search engines serve as metadata about the content of Web documents. In the semantic Web solutions, ontologies are used to store semantic metadata (Berners-Lee et al., 2001). Attaching a common ontology to a set of heterogeneous document databases may be used to support data integration. Creation of the common ontology requires profound understanding of the concepts used in the databases. It is a demanding task, especially in cases where the …