Search results for "RESISTANCE"
showing 10 items of 3641 documents
Effect of methyl jasmonate in gene expression, and in hormonal and phenolic profiles of holm oak embryogenic lines before and after infection with Ph…
2022
The dieback syndrome affecting Quercus ilex and other oak species impels the search for tolerant plant genotypes, as well as methods of plant immunization against such infections. Elicitation treatments can be an effective strategy to activate plant defense response and embryogenic lines represent a promising tool to generate new tolerant genotypes and also to study early markers involved in defense response. The aim of the presented work was to investigate changes in gene expression, and in hormonal and phenolic profiles induced in three holm oak embryogenic lines (ELs) elicited with methyl jasmonate (MeJA) before and after infection with the oomycete Phytophthora cinnamomi, which is the m…
Low physical activity and its association with diabetes and other cardiovascular risk factors: a nationwide, population-based study
2016
Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM; ISCIII Ministerio de Ciencia e Innovacion); Ministerio de Sanidad y Consumo; Spanish Diabetes Society (SED)
Antimicrobial susceptibility and quinolone resistance mechanism of Arcobacter butzleri isolates from sewage samples in Spain
2012
Haematocrit in metabolic syndrome
2004
In this paper are described normal and insulin resistant subjects, correlating the haematocrit value with M-index during euglycaemic hyperinsulinaemic clamp. The haematocrit value is related negatively with the M-value. We conclude that insulin resistance is a possible factor in determinating the blood viscosity in relation with the red cells/plasma ratio.
Effect of Injectable or Inhalational Anesthetics and of Neuroleptic, Neuroleptanalgesic, and Sedative Agents on Tumor Blood Flow
1988
Among other parameters, varying blood flow values may be responsible for tumor-to-tumor variabilities in the radiobiologically hypoxic cell fraction of experimental rodent tumors. To test whether changes in tumor blood flow may be caused by anesthetic agents often used in radiobiology, the effect of injectable and inhalational anesthetics and of neuroleptic, neuroleptanalgesic, and sedative agents on blood flow in subcutaneous DS-carcinosarcomas implanted in Sprague-Dawley rats has been investigated using the 85Kr clearance technique. In conscious rats, 20-100 min after animal instrumentation mean blood flow is 0.62 +/- 0.17 ml/g/min (mean +/- SD) in 0.75 +/- 0.15 g tumors at a mean arteria…
Invasive and native populations of common ragweed exhibit strong tolerance to foliar damage.
2013
8 pages; International audience; Tolerance and resistance are defence strategies evolved by plants to cope with damage due to herbivores. The introduction of exotic species to a new biogeographical range may alter the plant herbivore interactions and induce selection pressures for new plant defence strategies with a modified resource allocation. To detect evolution in tolerance to herbivory in common ragweed, we compared 3 native (North America) and 3 introduced (France) populations, grown in a common garden environment. We explored the effect of leaf herbivory on plant vegetative and reproductive traits. Plants were defoliated by hand, simulating different degrees of insect grazing by remo…
Flow resistance of overland flow on a smooth bed under simulated rainfall
2020
In this paper a recently theoretically deduced flow resistance equation, based on a power-velocity profile, was tested using laboratory measurements by Yoon and Wenzel for an overland flow on a smooth bed under rainfall. These measurements of the Darcy-Weisbach friction factor, corresponding to a wide range of the flow Reynolds number (191–5700), were carried out for an overland flow under a simulated rainfall characterized by different intensity values ranging from 13 to 381 mm h−1. At first, the available measured values of flow velocity, water depth, cross sectional area, wetted perimeter and bed slope were used to calibrate the relationship between the velocity profile parameter Γ, the …
Transverstites re-existences: A counterhistory from the visual difference in Peru
2018
El vínculo entre naturaleza y deshumanización es un discurso moderno colonial de género que mantiene su vigencia mediante la basurización simbólica y concreta de quienes son vistos como inferiores, antinaturales y hasta como animales, convertidos en un desecho de la sociedad. Una forma de visualizar al otro como elemento sobrante del sistema simbólico. En este sentido, maniobrar en el campo de la visualidad travesti, sus convenciones y estereotipos, se convierte en una práctica de resistencia en tanto que se enfrenta al régimen escópico eurocéntrico disciplinante, astutamente camuflado. Pero, igualmente, de re-existencia, al proponer la co-presencia visual de la diferencia, y por ende, la e…
Targeted Therapy Modulates the Secretome of Cancer-Associated Fibroblasts to Induce Resistance in HER2-Positive Breast Cancer
2021
The combination of trastuzumab plus pertuzumab plus docetaxel as a first-line therapy in patients with HER2-positive metastatic breast cancer has provided significant clinical benefits compared to trastuzumab plus docetaxel alone. However, despite the therapeutic success of existing therapies targeting HER2, tumours invariably relapse. Therefore, there is an urgent need to improve our understanding of the mechanisms governing resistance, so that specific therapeutic strategies can be developed to provide improved efficacy. It is well known that the tumour microenvironment (TME) has a significant impact on cancer behaviour. Cancer-associated fibroblasts (CAFs) are essential components of the…
6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4
2008
Multiple drug resistance protein 4 (MRP4, ABCC4) belongs to the C subfamily of the ATP-binding cassette (ABC) transporter superfamily and participates in the transport of diverse antiviral and chemotherapeutic agents such as 6-mercaptopurine (6-MP) and 9-(2-phosphonyl methoxyethyl) adenine (PMEA). We have undertaken a comprehensive functional characterization of protein variants of MRP4 found in Caucasians and other ethnicities. A total of 11 MRP4 missense genetic variants (nonsynonymous SNPs), fused to green fluorescent protein (GFP), were examined in Xenopus laevis oocytes for their effect on expression, localization, and function of the transporter. Radiolabeled 6-MP and PMEA were chosen…