Search results for "RESISTANCE"

Vazodilatācijas intensitātes un insulīna rezistences rādītāju saistība ar endoteliālo (dis)funkciju raksturojošo signālmolekulu koncentrācijām hronis…

2013

ANOTĀCIJA Pētījuma mērķis ir noskaidrot smēķēšanas ierosināta iekaisuma un oksidatīvā stresa ietekmi uz insulīna rezistences un endotēlija disfunkcijas attīstību un to savstarpējo sakarību. Pētījumā piedalījās 128 dalībnieki (starp kuriem 52 personām konstatējām dislipidēmiju), kuriem tika noteiktas ar endotēlija funkcijām saistītu signālmolekulu seruma koncentrācijas, vazodilatācijas intensitāte ādas mikrocirkulācijā un insulīna rezistenci raksturojoši rādītāji. Rezultāti parādīja, ka smēķēšanas kumulatīvais efekts būtiski sekmē insulīna rezistences attīstību personām ar dislipidēmiju, bet smēķēšanas akūtais efekts caur iekaisuma signālmolekulām īslaicīgi samazina šūnu insulīna jutību neat…

Hemorheology in the metabolic syndrome.

2011

Blood Flow, Vascular Resistance and Oxygen Availability in Malignant Tumours upon Intravenous Flunarizine

1987

Tumour blood flow, an important determinant of the efficacy of presently available nonsurgical cancer treatments, significantly increased following a single I.V. injection of the calcium antagonist flunarizine. At a dose of 1 mg/kg, tumour blood flow increased approximately by 28% without a significant change in mean arterial blood pressure. The flow increase was paralleled by a similar improvement of the O2 availability to the cancer cells. The data suggest that flunarizine may provide a means of improving delivery of antineoplastic agents to tumours. Furthermore, flunarizine may also enhance the effectiveness of irradiation by increasing tumour oxygenation.

The Future of Antibiotic: From the Magic Bullet to the Smart Bullet

2014

Cancer Stem Cells: From Birth to Death

2019

Abstract Conspicuous investigations have proven the role of cancer stem cells (CSCs) in the onset and progression of a plethora of liquid and solid neoplasms. CSCs are endowed with the capability of initiating tumor growth and becoming dormant at distant organ sites just waiting for optimal conditions amenable for metastatic outgrowth. This cancer subpopulation is inherently resistant to anticancer therapeutics, and its targeting could avoid metastatic disease, which is largely incurable, and clinical relapses. CSCs are considered the Achilles heel of cancer. However, many efforts are necessary to identify univocal CSC markers as well as specific CSC biomarkers of therapeutic response. Here…

Verschiedene Opioide beim kardiovaskul�ren Risikopatienten

1994

Efficient analgesia may be the major objective in the cardiovascular risk patient following myocardial infarction, acute occlusion of peripheral vessels, or dissection/perforation of major abdominal vessels. It was the purpose of the study to investigate the haemodynamic and respiratory side effects of eight different opioids in 57 circulatory risk patients prior to major vascular surgery. Methods. Patients were randomly allocated to eight groups, each receiving a different opioid within a clinical, equipotent dose range (buprenorphine, fentanyl, morphine, nalbuphine, pentazocine, pethidine, tramadol, alfentanil). A complete haemodynamic and blood gas status was obtained prior to as well as…

Prophylaxis, diagnosis and therapy of Hepatitis C Virus (HCV) infection : The German guidelines on the management of HCV infection

2010

Targeting tumor-initiating cells and compensatory YAP pathway to overcome sorafenib resistance in hepatocellular carcinoma

2021

Strategies to Overcome Drug Resistance in Acute and Chronic Leukemias

2009

Asthma and metabolic syndrome: Current knowledge and future perspectives

2014

Asthma and obesity are epidemiologically linked; however, similar relationships are also observed with other markers of the metabolic syndrome, such as insulin resistance and dyslipidemia, which cannot be accounted for by increased body mass alone. Obesity appears to be a predisposing factor for the asthma onset, both in adults and in children. In addition, obesity could make asthma more difficult to control and to treat. Although obesity may predispose to increased Th2 inflammation or tendency to atopy, other mechanisms need to be considered, such as those mediated by hyperglycaemia, hyperinsulinemia and dyslipidemia in the context of metabolic syndrome. The mechanisms underlying the associ…