Search results for "RESISTANCE"

DESIGN OF SF3B1 SUBUNIT MODULATORS OF THE SF3B SPLICEOSOME COMPLEX

2022

The subject of this dissertation is the search for new therapeutic strategies for pancreatic cancer and aims to implement a Drug Discovery process for the rational design and synthesis of molecules active in the modulation of pathways related to the regulation of pre-mRNA splicing process. This research project is the result of a joint PhD between the University of Palermo, Italy, and the Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands. It integrates complementary skills in pharmaceutical chemistry and translational cancer research with a special focus on the rational design of new anticancer compounds potentially active on SF3B1 (Splicing Factor 3B …

Split exercise training: comparison between endurance-resistance protocol, endurance-resistance-endurance protocol e resistance-endurance protocol.

2009

Numerosi studi hanno dimostrato, per la perdita di peso ed il miglioramento della composizione corporea, l’efficacia della presenza dell’esercizio aerobico ed anaerobico all’interno della stessa seduta di allenamento. Il dibattito resta però aperto riguardo alla distribuzione di queste due metodiche all’interno della medesima sessione, cioè se porre la parte “aerobica” all’inizio dell’allenamento, alla fine o, ancora, se intervallare ad essa il “lavoro anaerobico”. Alla luce di questo abbiamo condotto lo studio preliminare che verrà qui di seguito riportato. Abbiamo esaminato un campione di 25 donne e 11 uomini, per la durata di 6 settimane; i 2 gruppi sono stati suddivisi, a loro volta, in…

Experimental analysis, numerical and analytical modeling of shear strength mechanisms in Hybrid Steel Trussed Concrete Beams

2014

Does Stretching Training Influence Muscular Strength? A Systematic Review With Meta-Analysis and Meta-Regression

2022

Thomas, E, Ficarra, S, Nunes, JP, Paoli, A, Bellafiore, M, Palma, A, and Bianco, A. Does stretching training influence muscular strength? A systematic review with meta-analysis and meta-regression. J Strength Cond Res XX(X): 000-000, 2022-This aim of this study was to review articles that performed stretching training and evaluated the effects on muscular strength. Literature search was performed using 3 databases. Studies were included if they compared the effects on strength following stretching training vs. a nontraining control group or stretching training combined with resistance training (RT) vs. an RT-only group, after at least 4 weeks of intervention. The meta-analyses were performe…

Sympathoadrenal response to resistance exercise in men, women and pubescent boys : with special reference to interaction with other hormones and neur…

2001

The Effects of Combined Same Session Aerobic and Resistance Training on Physical Performance in Coronary Artery Disease Patients : Protocol Comparison

2021

Aerobic training is included to cardiac rehabilitation programs together with resistance training. The effects of combined aerobic and resistance training performed in a same session with different protocols on peak aerobic capacity (VO2peak) and maximal dynamic strength (1RM: one repetition maximum) are not well known. We compared the effectiveness of two different combined aerobic and resistance training programs for 12 weeks performed three times in a week in stable Coronary Artery Disease (CAD) patients (n=30) who had previously performed aerobic training only. The patients were randomized to High Volume- Low Intensity Group (HLG) or Low Volume-High Intensity Group (LHG). Both groups pe…

Acute Neuromuscular and Hormonal Responses to Power, Strength, and Hypertrophic Protocols and Training Background

2022

This study investigated how two slightly different athlete groups would differ in acute neuromuscular and endocrine responses to specific resistance exercise loadings and recovery compared to untrained participants. Power athletes (PA, n = 8), strength athletes (SA, n = 8) and non-athletes (NA, n = 7) performed power (PL, 7 × 6 × 50% of 1RM), maximal strength (MSL, 7 × 3 × 3RM), and hypertrophic (HL, 5 × 10 × 10RM) loadings in Smith-machine back-squat. Neuromuscular performance, serum testosterone, growth hormone, and cortisol concentrations, and blood lactate (BL) were measured before (Pre), at Mid and after (Post) loading, and after recovery for 24 and 48 h. All loadings led to acute decr…

Effects of Task-Specific and Strength Training on Simulated Military Task Performance in Soldiers.

2020

A soldier’s occupational physical task requirements are diverse and varied. However, the type of physical training that most effectively improves soldiers’ occupational task requirements has not been studied previously. The purpose of this study was to determine the important strength characteristics for soldiers during a repeated simulated military task course, and the type of training that may be effective to improve these abilities during a specialized military training period. Forty-two (n = 42) soldiers participated in the study. They were divided into three training groups; a soldier task-specific training group (TSG, n = 17), a strength training group (STG, n = 15), and a control gro…

Onset of Insulin Resistance in Hippocampal Synapses After Traumatic Brain Injury: Relevance to Alzheimer’s disease and Therapeutic Implications

Surrogate-assisted evolutionary multiobjective shape optimization of an air intake ventilation system

2017

We tackle three different challenges in solving a real-world industrial problem: formulating the optimization problem, connecting different simulation tools and dealing with computationally expensive objective functions. The problem to be optimized is an air intake ventilation system of a tractor and consists of three computationally expensive objective functions. We describe the modeling of the system and its numerical evaluation with a commercial software. To obtain solutions in few function evaluations, a recently proposed surrogate-assisted evolutionary algorithm K-RVEA is applied. The diameters of four different outlets of the ventilation system are considered as decision variables. Fr…