Search results for "RIG"

Hemispheric Differences in Functional Interactions Between the Dorsal Lateral Prefrontal Cortex and Ipsilateral Motor Cortex

2020

Background: The dorsolateral prefrontal cortex (DLPFC) in both hemispheres have a central integrative function for motor control and behavior. Understanding the hemispheric difference between DLPFC and ipsilateral motor cortex connection in the resting-state will provide fundamental knowledge to explain the different roles DLPFC plays in motor behavior. Purpose: The current study tested the interactions between the ipsilateral DLPFC and the primary motor cortex (M1) in each hemisphere at rest. We hypothesized that left DLPFC has a greater inhibitory effect on the ipsilateral M1 compared to the right DLPFC. Methods: Fourteen right-handed subjects were tested in a dual-coil paired-pulse parad…

Spontaneous labour at term is associated with fetal monocyte activation.

1999

SUMMARYThe aetiology of both term and preterm labour remains incompletely understood. Maternal infectious diseases as well as intra-uterine infections were shown to be a well established cause of uncontrollable preterm delivery, indicating that inflammatory reactions, regulated by maternal immunecompetent cells, are implicated in labour-promoting mechanisms. To investigate the possibility that the activation of the fetal immune system may be involved in labour induction, we examined cytokine production patterns of different cord blood cell populations obtained from neonates after spontaneous onset of normal term labour and vaginal delivery (n = 25), vaginal delivery but induced term labour …

Natural Killer Group 2D Ligand Depletion Reconstitutes Natural Killer Cell Immunosurveillance of Head and Neck Squamous Cell Carcinoma

2017

Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous and aggressive tumor originating from the epithelial lining of the upper aero-digestive tract accounting for 300,000 annual deaths worldwide due to failure of current therapies. The natural killer group 2D (NKG2D) receptors on natural killer (NK) cells and several T cell subsets play an important role for immunosurveillance of HNSCC and are thus targeted by tumor immune evasion strategies in particular by shedding of various NKG2D ligands (NKG2DLs). Based on plasma and tumor samples of 44 HNSCC patients, we found that despite compositional heterogeneity the total plasma level of NKG2DLs correlates with NK cell inhibitio…

T cell–mediated response to SARS‐CoV‐2 in liver transplant recipients with prior COVID‐19

2021

Abstract Whether immunosuppression impairs severe acute respiratory syndrome coronavirus 2‐specific T‐cell‐mediated immunity (SARS‐CoV‐2‐CMI) after liver transplantation (LT) remains unknown. We included 31 LT recipients in whom SARS‐CoV‐2‐CMI was assessed by intracellular cytokine staining (ICS) and interferon (IFN)‐γ FluoroSpot assay after a median of 103 days from COVID‐19 diagnosis. Serum SARS‐CoV‐2 IgG antibodies were measured by ELISA. A control group of non‐transplant immunocompetent patients were matched (1:1 ratio) by age and time from diagnosis. Post‐transplant SARS‐CoV‐2‐CMI was detected by ICS in 90.3% (28/31) of recipients, with higher proportions for IFN‐γ‐producing CD4+ than …

Temporomandibular joint arthrocentesis. Review of the literature.

2011

The treatment of the temporomandibular joint (TMJ) is still controversial. TMJ arthrocentesis represents a form of minimally invasive surgical treatment in patients suffering from internal derangement of the TMJ, especially closed lock. It consists of washing the joint with the possibility of depositing a drug or other therapeutic substance. Resolution of symptoms is due to the removal of chemical inflammatory mediators and changes in intra-articular pressure. Numerous clinical studies regarding this technique have been published. The goal of this paper is to review all clinical articles that have been published with regard to the critique of this technique. 19 articles with different desig…

Neural Mechanisms of Acceptance and Commitment Therapy for Chronic Pain: A Network-Based fMRI Approach

2021

AbstractOver 100 million Americans suffer from chronic pain (CP), which causes more disability than any other medical condition in the U.S. at a cost of $560-$635 billion per year (IOM, 2011). Opioid analgesics are frequently used to treat CP. However, long term use of opioids can cause brain changes such as opioid-induced hyperalgesia that, over time, increase pain sensation. Also, opioids fail to treat complex psychological factors that worsen pain-related disability, including beliefs about and emotional responses to pain. Cognitive behavioral therapy (CBT) can be efficacious for CP. However, CBT generally does not focus on important factors needed for long-term functional improvement, i…

'Un ritmo dei Carmina Cantabrigensia'

2003

Znaczenie roślinnych i syntetycznych składników aktywnych we wspomaganiu procesu depigmentacji skóry

2021

Melanogenesis is a process catalyzed by tyrosinase enzyme leading to synthesis of two types of pigment in the skin: black-brown eumelanin and red-yellow pheomelanin. Pheomelanin is synthesized in the second stage of melanosome maturation, while eumelanin-synthesizing melanosomes are inactive. The black-brown pigment is produced in the third stage of melanosome development. The last, fourth stage of melanosome maturation is characterized by low tyrosinase activity, which reflects the low pigment production in the skin. The process of skin pigment production (melanogenesis) is mainly regulated by solar radiation, hormones and other endo- and exogenous factors. Over- stimulated melanogenesis l…

“Throwing into the Whirlwind Vortex”: Unaccounted Memoirs about Blok by S. Korenev

2021

The article examines certain plots of the “Blok theme” in the 1920s Riga periodicals, which had not previously attracted the attention of researchers. The Russian press of independent Latvia (1919 –1940) has preserved many tens, if not hundreds, of articles, correspondences, documents, poetic texts dedicated to A.A. Blok’s personality and works. Among them are memoirs of people who were familiar with the poet, met with him, listened to his speeches. However, most of these scattered memoirs remain forgotten and are not taken into account in the Blok studies. The author recalls the texts of V.V. Tretyakov, A.M. Perfiliev and republishes from the Riga newspaper “Slovo” a memorial article about…

Rumor de pañuelo blanco: historia, memoria y representaciones literarias de Abuelas de Plaza de Mayo

2018

El 24 de marzo de 2016 se cumplieron 40 años del golpe de Estado del autodenominado Proceso de Reorganización Nacional que condujo a siete años de una sangrienta dictadura en Argentina. De entre las organizaciones de Derechos Humanos que surgieron como respuesta a las desapariciones ilegales de militantes y de civiles, las Madres y Abuelas de Plaza de Mayo se han constituido, tanto a nivel nacional como internacional, en evidencia de la historia de violencia y en símbolo de paz; como tales también han entrado en el plano de la ficción. Teniendo en cuenta estas líneas, en el presente trabajo se realiza, primero, un recorrido por la historia de las Abuelas de Plaza de Mayo y el cambio polític…