Search results for "RIG"

CD40 activity on mesenchymal cells negatively regulates OX40L to maintain bone marrow immune homeostasis under stress conditions

2021

BackgroundWithin the bone marrow (BM), mature T cells are maintained under homeostatic conditions to facilitate proper hematopoietic development. This homeostasis depends upon a peculiar elevated frequency of regulatory T cells (Tregs) and immune regulatory activities from BM-mesenchymal stem cells (BM-MSCs). In response to BM transplantation (BMT), the conditioning regimen exposes the BM to a dramatic induction of inflammatory cytokines and causes an unbalanced T-effector (Teff) and Treg ratio. This imbalance negatively impacts hematopoiesis, particularly in regard to B-cell lymphopoiesis that requires an intact cross-talk between BM-MSCs and Tregs. The mechanisms underlying the ability of…

Scholarly publishing depends on peer reviewers

2018

The peer-review crisis is posing a risk to the scholarly peer-reviewed journal system. Journals have to ask many potential peer reviewers to obtain a minimum acceptable number of peers accepting reviewing a manuscript. Several solutions have been suggested to overcome this shortage. From reimbursing for the job, to eliminating pre-publication reviews, one cannot predict which is more dangerous for the future of scholarly publishing. And, why not acknowledging their contribution to the final version of the article published? PubMed created two categories of contributors: authors [AU] and collaborators [IR]. Why not a third category for the peer-reviewer? published

Profiling microbial communities in hyperalkaline waters of the Kizildag ophiolite complex (Turkey).

2016

It has recently been hypothesized that life on Earth could have been originated in hyperalkaline waters related to serpentinization of ophiolitic rocks, despite their extreme conditions (high pH and very low levels of nutrients). Five hyperalkaline springs of the Kizildag ophiolite complex (Turkey) were characterized. The dominant gases are either H2, CH4 or N2 . Bacterial diversity, analysed by RISA (Ribosomal Intergenic Spacer Analysis) revealed different profles for each spring. Sequencing of excised DNA bands allowed to identify the presence of Bacillus, Ralstonia, Pseudoalteromonas., Ureibacillus, Alicycliphilus, Anaerococcus. 16S ribosomal DNA sequencing by Illumina is in progress. Th…

Differential of metric valued Sobolev maps

2020

We introduce a notion of differential of a Sobolev map between metric spaces. The differential is given in the framework of tangent and cotangent modules of metric measure spaces, developed by the first author. We prove that our notion is consistent with Kirchheim's metric differential when the source is a Euclidean space, and with the abstract differential provided by the first author when the target is $\mathbb{R}$.

Poly(I:C) and CpG-ODN combined aerosolization to treat lung metastases and counter the immunosuppressive microenvironment.

2015

The immunostimulatory ability of synthetic oligonucleotides containing CpG motifs (CpG-ODN), agonists of Toll-like receptor 9 (TLR9), can be harnessed to promote antitumor immunity by their application at the tumor site to stimulate local activation of innate immunity; however, particularly in the lung, tumor-associated immunosuppression can subvert such antitumor innate immune responses. To locally maintain continuous activation of innate subpopulations while inhibiting immunosuppressive cells, we evaluated aerosol delivery CpG-ODN combined with Poly(I:C), a TLR3 agonist able to convert tumor-supporting macrophages to tumoricidal effectors, in the treatment of B16 melanoma lung metastases …

IL SOFTWARE IRRILAB PER GLI IMPIANTI MICROIRRIGUI: VERIFICHE NUMERICHE E SPERIMENTALI

2018

Nell’ambito delle attività di ricerca condotte presso il Dipartimento di Scienze Agrarie, Alimentari e Forestali dell’Università di Palermo è stato di recente messo a punto un nuovo metodo di calcolo ottimale delle ali gocciolanti, usate nella mi-croirrigazione, attualmente patent pending (“Metodo speditivo per il dimensiona-mento di ali gocciolanti in pendenza”, Università deli Studi di Palermo, Ministero dello Sviluppo Economico - Ufficio Italiano Brevetti e Marchi). Il metodo è stato successivamente esteso ai settori microirrigui, di forma rettangolare e comunque inclinati, in un software applicativo, denominato IrriLab. L’obiettivo del lavoro è quello di “testare” il funzionamento del s…

Is It Possible to Produce Certified Hazelnut Plant Material in Sicily? Identification and Recovery of Nebrodi Genetic Resources, in vitro Establishme…

2021

Eight Sicilian cultivars of hazelnut (Corylus avellanaL.), namely-Curcia, Nociara Collica, Panottara Collica, Panottara Galati Grande, Parrinara, Panottara Baratta Piccola, Enzo, and Rossa Galvagno, registered into the Italian Cultivar Register of fruit tree species in 2017 were selected from Nebrodi area and establishedin vitro. The aim of the work was to carry out the sanitation of the cultivars and get virus-free plants from the most important viral pathogen threat, theapple mosaic virus. Virus-free plant material is essential for the production of certified plants from Sicilian hazelnut cultivars, complying the CE (cat. CAC) quality and the technical standards established in 2017 for vo…

Aspetti microbiologici del latte crudo mantenuto a diverse temperature per la produzione di Grana Trentino

2008

Covid-19 and Inequalities. Protecting Human Rights of Migrants in a Time of Pandemic

2020

By focusing on the Italian context, this article explores the human rights violations that migrants systematically experience and that the current health crisis is unveiling and, in turn, producing. In particular, we look at these dynamics by taking into account four issues/dimensions: the access to essential services and benefits, such as food vouchers; working and living conditions; conditions in reception and detention centres; and the denial of entry to reach ports of safety.

MIGRATIONS AND THE CENTER OF THE AFRICAN FACE OF SICILY

2010

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