Search results for "RILL"

Metilazione del DNA in artrite reumatoide

2005

Lo stato di metilazione del DNA genomico e del gene PTHrP è stato valutato con tecniche molecolari e citogenetiche in artrite reumatoide (AR), patologia autoimmune caratterizzata anche da alta incidenza di linfomi e da ipercalcemia per overespressione del gene PTHrP. La metilazione del DNA, infatti, ha un ruolo critico nello sviluppo delle malattie neoplastiche; il gene PTHrP avendo tre promotori uno dei quali contiene un’isola CpG è un buon candidato per la deregolazione da alterato pattern di metilazione locale. Le indagini sulla metilazione genomica, condotte su DNA estratto da sangue periferico di pazienti e di donatori e amplificato in reazioni di Methylation-Sensitive Arbitrarily Prim…

Casein-loaded proteoliposomes: novel delivery strategy to inhibit Aβ1-40 fibrillogenesis in Alzheimer disease

2018

Background: Alzheimer's disease (AD) is a chronic and progressive syndrome, which represents the most common cause of dementia worldwide. A pathological and characteristic AD hallmark is the deposition of amyloid plaques, composed by well-ordered amyloid β-peptide (Aβ) fibers, in brain tissue. The Aβ aggregation process follows typical nucleation-polymerization kinetics, characterized by structural intermediates with specific dimensions, morphologies and cytotoxic activity. Some evidences shifted researchers’ attention to smaller soluble Aβ prefibrillar oligomers as they result the most toxic species. Therefore, novel therapeutic strategies target oligomers or prefibrillar aggregates rather…

Ocular Drug Delivery Systems per la veicolazione di molecole bioattive al segmento posteriore dell'occhio

Casein-loaded proteoliposomes: Drug Delivery Systems and Potential Inhibitors in Aβ1-40 Fibrillogenesis

2018

Alzheimer's disease (AD) represents the most common cause of dementia worldwide. The early symptom is usually a short-term memory loss, followed by symptoms including problems with language, disorientation, mood swings, loss of motivation, not managing self-care, and behavioral issues, until loss of body functions and, ultimately, death. The cause of AD is poorly understood and the diagnosis is complex. One of the main AD hallmarks is the extracellular deposition in brain tissue of proteinaceous amyloid plaques, composed by well-ordered fibrillary aggregates of the amyloid β-peptide (Aβ). The Aβ aggregation process follows typical nucleation-polymerization kinetics, characterized by structu…

SELF ASSEMBLED AND CROSSLINKED FIBRILLAR SCAFFOLDS FOR CARTILAGE REGENERATION.

2010

Perforazione della Caldera dei Campi Flegrei - Una proposta anfibia IODP-ICDP

2018

Active calderas are major volcanic features of the Earth’s crust associated with shallow magma reservoirs, high geothermal gradients, and geodynamic unrests often documented through historical time. As large caldera-forming eruptions are also among the most catastrophic events that may affect the Earth’s surface, calderas are ostensibly the sites of major interest for both the scientific community and governmental institutions worldwide. The Campi Flegrei is an active volcanic area located west of the city of Naples, largely on the continental shelf of the Eastern Tyrrhenian margin that has been characterized by dominantly explosive eruptions during the latest Quaternary. This is one among …

New tailor-made bio-organoclays for the remediation of olive mill waste water

2013

A systematic study aimed at obtaining new organoclays for the treatment of Olive Mill Waste water (OMW) has been performed. Several organoclays have been prepared by loading different amounts of the biocompatible surfactant Tween20 onto the K10 montmorillonite (MMT). Complementary kinetic and equilibrium studies on the adsorption of the Tween20 onto the MMT have been carried out and the characterization of the new tailor-made bio-materials has been performed by means of the XRD and FT-IR measurements. Finally the prepared bio-organoclays have been successfully applied for the OMW remediation and they proved to be highly effective in decreasing the organic content (OC) to an extent that depe…

Synthesis and characterization of taylor-made organo-clays for biotechnological applications

2014

1D Compression Behaviour of Opalinus Clay

2017

One of the main concerns related to tunnel excavations, drilling operations and wellbore stability in shales is the generation of excess pore water pressure due to changes in mechanical stress; therefore the consolidation of shales is a fundamental process that must be considered. This paper presents a compre- hensive methodology for analysing the compression and consolidation behaviour of shales. An apparatus to perform high-pressure oedometric tests is presented and an analytical method is introduced to analyse the shale consolidation behaviour, which allows information to be gathered on the coeffi cient of consolidation, stiffness, poroelastic properties, and permeability of the tested m…

Amare Palermo. Un ricordo di Salvatore Mario Inzerillo

2017

Ripubblicare, a distanza di oltre tre decenni, in un unico volume "Urbanistica e società negli ultimi duecento anni a Palermo", di Salvatore Mario Inzerillo, potrebbe apparire come il frutto di un’azione nostalgica. Una sorta di riconoscimento, di omaggio post mortem, a un docente al quale molti degli attuali professori del Dipartimento di Architettura, prima studenti della Facoltà, sono rimasti legati. Riconosco che l’aspetto affettivo è presente però è marginale nella mia decisione di volere ripubblicare i due volumi e, su tale necessità, dare avvio alla nuova collana D’Arch Reprint. Scrivo in termini di necessità, di bisogno, perché ho sempre pensato, da quando ho avuto modo di conoscere…