Search results for "RIMI"
showing 10 items of 3981 documents
Organized crime and public spending: a panel data analysis
2018
The aim of this paper is to investigate, empirically, what components of public spending imply a decreasing effect on organized crime and what components create opportunities for organized crime, discussing also the role of government efficiency. Using a panel data analysis, the results show a strikingly consistent pattern for the EU Member States. Organized crime mainly operates in the distribution of government spending for local public goods and public provision of private services. There is a decreasing effect on organized crime of the public expenditure devoted to education and social policy. Government efficiency in public spending is beneficial to limit the opportunities of the organ…
Insect immunity: oral exposure to a bacterial pathogen elicits free radical response and protects from a recurring infection
2014
Background: Previous exposure to a pathogen can help organisms cope with recurring infection. This is widely recognised in vertebrates, but increasing occasions are also being reported in invertebrates where this phenomenon is referred to as immune priming. However, the mechanisms that allow acquired pathogen resistance in insects remain largely unknown. Results: We studied the priming of bacterial resi stance in the larvae of the tiger moth, Parasemia plantaginis using two gram-negative bacteria, a pathogenic Serratia marcescens and a non-pathogenic control, Escherichia coli. Asublethaloraldoseof S. marcescens provided the larvae with effective protection against an otherwise lethal septic…
Incremental Gaussian Discriminant Analysis based on Graybill and Deal weighted combination of estimators for brain tumour diagnosis
2011
In the last decade, machine learning (ML) techniques have been used for developing classifiers for automatic brain tumour diagnosis. However, the development of these ML models rely on a unique training set and learning stops once this set has been processed. Training these classifiers requires a representative amount of data, but the gathering, preprocess, and validation of samples is expensive and time-consuming. Therefore, for a classical, non-incremental approach to ML, it is necessary to wait long enough to collect all the required data. In contrast, an incremental learning approach may allow us to build an initial classifier with a smaller number of samples and update it incrementally…
Texture analysis for infarcted myocardium detection on delayed enhancement MRI
2017
Detection of infarcted myocardium in the left ventricle is achieved with delayed enhancement magnetic resonance imaging (DE-MRI). However, manual segmentation is tedious and prone to variability. We studied three texture analysis methods (run-length matrix, co-occurrence matrix, and autoregressive model) in combination with histogram features to characterize the infarcted myocardium. We evaluated 10 patients with chronic infarction to select the most discriminative features and to train a support vector machine (SVM) classifier. The classifier model was then used to segment five human hearts from the STACOM DE-MRI challenge at MICCAI 2012. The Dice coefficient was used to compare the segmen…
SIMULATION EXPERIMENTS WITH MULTIPLE GROUP LINEAR AND QUADRATIC DISCRIMINANT ANALYSIS
1973
Summary A simulation program is described which can be performed to obtain estimates of the different types of misclassification probabilities for multiple group linear and quadratic discriminant analysis. The program can be used to study how these errors depend on sample sizes and the different parameters of the multivariate normal distribution. Examples for several simulation experiments are given and possible conclusions are discussed.
Resocialisation program “Miriam” as a Christian subculture group in female prison
2016
The paper aims to study the similarities and differences between small or informal groups in prison subculture and re-socialization program “Miriam”, which is created as a different cultural space in female prison. The dominating norms in the small groups in prison subculture the values, artefact, leader, table culture, and a sense of space and time strengthens the convicted person's criminal identity. Under the program “Miriam”, which also has elements of prisoner small group subculture, women are offered to learn about different cultural and artistic values together with fundamental Christianity values by program leaders – well-known people from Art and Culture area. With this kind of app…
Derecho antidiscriminatorio y protección de los colectivos en situación de vulnerabilidad en las constituciones de Ecuador de 2008 y de Bolivia de 20…
2019
El sujeto político que protagonizó los procesos constituyentes de Bolivia y Ecuador no estaba conformado por un partido obrero clásico sino por la agregación de múltiples movimientos o luchas de grupos en situación de vulnerabilidad. Esta naturaleza del sujeto constituyente determinó que la forma de constitucionalismo social emergente no se basara, como el europeo, en la subjetivación del trabajo y reconocimiento de derechos vinculados al trabajosalario, sino en la visibilización de los grupos sociales hasta ahora excluidos y en su inclusión a la ciudadanía. Ello explica que se traten de textos muy ricos en referencias y mecanismos para el reconocimiento y garantía de los derechos específic…
Oxidative DNA base damage induced by singlet oxygen and photosensitization: recognition by repair endonucleases and mutagenicity.
2000
We have analyzed the recognition by various repair endonucleases of DNA base modifications induced by three oxidants, viz. [4-(tert-butyldioxycarbonyl)benzyl]triethylammonium chloride (BCBT), a photochemical source of tert-butoxyl radicals, disodium salt of 1,4-etheno-2,3-benzodioxin-1,4-dipropanoic acid (NDPO(2)), a chemical source of singlet oxygen, and riboflavin, a type-I photosensitizer. The base modifications induced by BCBT, which were previously shown to be mostly 7,8-dihydro-8-oxoguanine (8-oxoGua) residues, were recognized by Fpg and Ogg1 proteins, but not by endonuclease IIII, Ntg1 and Ntg2 proteins. In the case of singlet oxygen induced damage, 8-oxoGua accounted for only 35% of…
Fanconi's anaemia cells have normal steady-state levels and repair of oxidative DNA base modifications sensitive to Fpg protein
1998
Abstract Cells from Fanconi's anaemia (FA) patients are abnormally sensitive to oxygen. However, a distinct genetic defect in either the cellular defence against reactive oxygen species (ROS) or in their metabolic generation has not been identified to date. Recently, the gene for the human 8-hydroxyguanine (8-oxoG) glycosylase, which removes this oxidative base modification from the genome, has been localized on chromosome 3p25, i.e., in the same region as the FA complementation group D (FAD) gene. We therefore studied the removal of photosensitization-induced 8-oxoG residues from the DNA of FA cells, using Fpg protein, the bacterial 8-oxoG glycosylase, to quantify the lesions by alkaline e…
Widespread transcriptional gene inactivation initiated by a repair intermediate of 8-oxoguanine.
2016
DNA damage can significantly modulate expression of the affected genes either by direct structural interference with transcription components or as a collateral outcome of cellular repair attempts. Thus, DNA glycosylases of the base excision repair (BER) pathway have been implicated in negative transcriptional response to several spontaneously generated DNA base modifications, including a common oxidative DNA base modification 8-oxoguanine (8-oxoG). Here, we report that single 8-oxoG situated in the non-transcribed DNA strand of a reporter gene has a pronounced negative effect on transcription, driven by promoters of various strength and with different structural properties, including viral…