Search results for "RIMI"

showing 10 items of 3981 documents

Synthesis and antiproliferative mechanism of action of pyrrolo[3′,2′:6,7] cyclohepta[1,2-d]pyrimidin-2-amines as singlet oxygen photosensitizers

2016

A new series of pyrrolo[3′,2′:6,7]cyclohepta[1,2-d]pyrimidin-2-amines, was conveniently prepared using a versatile and high yielding multistep sequence. A good number of derivatives was obtained and the cellular photocytotoxicity was evaluated in vitro against three different human tumor cell lines with EC50 (0.08–4.96 μM) values reaching the nanomolar level. Selected compounds were investigated by laser flash photolysis. The most photocytotoxic derivative, exhibiting a fairly long-lived triplet state (τ ∼ 7 μs) and absorbance in the UV–Vis, was tested in the photo-oxidations of 9,10-anthracenedipropionic acid (ADPA) by singlet oxygen. The photosentizing properties are responsible for the c…

0301 basic medicinemedicine.medical_treatmentPhotodynamic therapyChemistry Techniques SyntheticAntiproliferative activityPhotochemistry01 natural sciencesPhotodynamic therapychemistry.chemical_compound7]cyclohepta[1Drug DiscoveryTriplet stateAmineschemistry.chemical_classificationPhotosensitizing AgentsCell DeathSinglet OxygenChemistrySinglet oxygenGeneral MedicineAntiproliferative activity; Photodynamic therapy; Photosensitizing agents; Pyrrolo[3′; 2′:6; 7]cyclohepta[1; 2-d]pyrimidin-2-amines; Reactive oxygen species; Drug Discovery3003 Pharmaceutical Science; Organic Chemistry; PharmacologyPyrrolo[3′2′:67]cyclohepta[12-d]pyrimidin-2-amineSettore ING-IND/22 - Scienza E Tecnologia Dei Materiali2-d]pyrimidin-2-aminesFlash photolysisReactive oxygen specieKineticsAntineoplastic AgentsAbsorbance03 medical and health sciencesCell Line TumormedicineHumansPyrrolo[3′Cell ProliferationPharmacologyReactive oxygen speciesPhotosensitizing agentPhotolysis010405 organic chemistry2′:6Drug Discovery3003 Pharmaceutical SciencePhotodissociationOrganic ChemistryCombinatorial chemistrySettore CHIM/08 - Chimica Farmaceutica0104 chemical sciencesAntiproliferative activity; Photodynamic therapy; Photosensitizing agents; Pyrrolo[3′2′:67]cyclohepta[12-d]pyrimidin-2-amines; Reactive oxygen species; Drug Discovery3003 Pharmaceutical Science; Organic Chemistry; PharmacologyKinetics030104 developmental biologyDrug DesignReactive oxygen species
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Knowledge, Awareness And Perceptions Of Females On Clandestine Abortion In Kintampo North Municipality, Ghana

2016

Clandestine Abortion will continue to be an integral part of human society as long as people continue to accept and engage in sexual activities without being prepared to give birth. Despite the risks (death and other health complication) involved in clandestine abortion, people continue to engage in the act. The central inquiry is; why do people continue to do clandestine abortions despite its associated risk? Do people have knowledge on abortion concerning its legalities and associated risks? This paper thus seeks to clarify the above questions by examining the knowledge, awareness and perceptions of females on abortion, with focus on clandestine abortion in the Kintampo North Municipality…

030219 obstetrics & reproductive medicinePovertyKnowledge awarenessmedia_common.quotation_subjectAbortionCriminologyAbortion law03 medical and health sciences0302 clinical medicinePolitical sciencePerceptionembryonic structures030212 general & internal medicinePublic educationHuman societySocial psychologyreproductive and urinary physiologymedia_commonEuropean Scientific Journal, ESJ
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A matching task as a potential technique for descriptive profile validation

2003

If panellists can successfully match products to the corresponding descriptive profiles, then the profiles can be regarded as product-relevant and valid. This work examined the ability of a trained panel to perform a matching task between products and their descriptive profiles. A 13-member panel, trained to assess eight cheeses in terms of 19 flavour attributes, performed the task based on their individually developed profiles. The panel's ability to match products to profiles was well above that expected by chance, and chi-square statistics for each of the products were significant (P<0.05). A correspondence analysis based on the group results indicated that all the products were relative…

0303 health sciencesMatching (statistics)Nutrition and Dietetics030309 nutrition & dietetics04 agricultural and veterinary sciences[SDV.IDA] Life Sciences [q-bio]/Food engineering040401 food scienceSensory analysisRegressionCorrespondence analysisCanonical analysisTask (project management)03 medical and health sciences0404 agricultural biotechnologyDiscriminantConsistency (statistics)Statistics[SDV.IDA]Life Sciences [q-bio]/Food engineeringAlgorithmComputingMilieux_MISCELLANEOUSFood ScienceMathematics
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Risk tables for discrimination tests

1993

Abstract Duo-trio and triangle test are often used in the food industry for the purpose of declaring two products non-distinguishable. In that situation, it is much more important to control the power of the test rather than the type 1 error risk. This paper makes available by e-mail a SAS ® macro, called BINRISKS, for computing type 1 and type 2 risks for any one-tailed binomial test and for any level of the percentage above chance to be detected. Using this macro, two sets of tables have been compiled. The first table includes for any total number of responses below 50, for any number of correct responses and for three levels of the percentage above chance to be detected, the correspondin…

0303 health sciencesNutrition and Dietetics030309 nutrition & dieteticsBinomial test04 agricultural and veterinary sciences[SDV.IDA] Life Sciences [q-bio]/Food engineering040401 food scienceDiscrimination testingTest (assessment)03 medical and health sciences0404 agricultural biotechnology[SDV.IDA]Life Sciences [q-bio]/Food engineeringStatisticsEconometricsTable (database)MacroComputingMilieux_MISCELLANEOUSFood ScienceTriangle testMathematicsType I and type II errorsFood Quality and Preference
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Policiers, gendarmes et signalement descriptif. Représentations, apprentissages et pratiques d'une nouvelle technique de police judiciaire, en France…

2006

À partir des années 1880, les nouveaux procédés d’identification développés par Alphonse Bertillon à la Préfecture de police de Paris représentent des moyens modernes et efficaces de police judiciaire face à une criminalité perçue comme irrésistible. Parmi ceux-ci, le signalement descriptif, ou « portrait parlé », est réputé permettre la reconnaissance infaillible d’un individu dont les traits du visage auraient été minutieusement décrits par cette technique particulière. Fait notable, sans doute inédit et sans équivalent alors, cette technique est enseignée aux divers acteurs de la police française – policiers de la Préfecture de police, de la Sûreté générale, mais aussi gendarmes et garde…

0303 health sciences[SHS.SOCIO]Humanities and Social Sciences/Sociology[ SHS.HIST ] Humanities and Social Sciences/History[SHS.SOCIO] Humanities and Social Sciences/SociologyGeneral Medicine[ SHS.SOCIO ] Humanities and Social Sciences/Sociology16. Peace & justiceAntropométrie criminellerapports policiers-gendarmes03 medical and health sciences0302 clinical medicinepolice judiciaire[SHS.HIST] Humanities and Social Sciences/History030220 oncology & carcinogenesisformation professionnelle[SHS.HIST]Humanities and Social Sciences/HistoryGeneralLiterature_REFERENCE(e.g.dictionariesencyclopediasglossaries)signalement descriptifComputingMilieux_MISCELLANEOUS030304 developmental biology
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“Minding the gap” in the research on human trafficking for sexual purposes

2017

Since the signature of the United Nations Trafficking Protocol in December 2000 that human trafficking has been labelled as a transnational, complex criminal phenomenon. However, despite the implementation of international soft law instruments to tackle the phenomenon, human trafficking is constantly evolving by the frequent changes of strategies, routes, types of exploitation and methodologies applied by the criminal networks. This flexibility of the phenomenon does not only difficult the implementation of effective tackling measures, but it also demonstrates to be an obstacle to produce accurate information on the subject (Cusick et al, 2009). Furthermore, due to the hidden nature of the …

05 social sciences0507 social and economic geographyGender studiesCriminologyethical issues sexual exploitation0506 political scienceHuman TraffickingParticipant Observation050602 political science & public administrationSettore SPS/12 - Sociologia Giuridica Della Devianza E Mutamento SocialeHuman traffickingSettore SPS/07 - Sociologia GeneraleSociology050703 geographyQualitative Research
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Delincuencia violenta, abuso y no consumo de drogas en adolescentes con riesgo de reincidencia

2020

espanolPresentamos un estudio original sobre consumo/abstinencia de drogas en adolescentes y su asociacion con el riesgo de reincidencia violenta. A una muestra de 192 sujetos se le aplico el cuestionario SAVRY –Structured Assessment of Violence Risk in Youth–, con el objetivo de analizar la asociacion entre el riesgo de reincidencia en delitos violentos y el consumo y abstinencia de drogas. Los resultados mostraron que: el no consumo se asocia al riesgo de reincidencia en delitos violentos intrafamiliares, el consumo de cocaina a robo con violencia e intimidacion, y el policonsumo de drogas al riesgo de reincidencia en diferentes delitos, siendo comun el ataque contra las personas. Las con…

05 social sciencesCommunity prevention030508 substance abuseGeneral Social SciencesFamily communicationAdolescents03 medical and health sciences050501 criminologyDelinqüència juvenilViolència juvenilViolence risk0305 other medical sciencePsychologyHumanities0505 law
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Latent Profile Approach to Duration of Stalking

2010

Stalking behavior and victim-stalker relationship are often the principal known factors in a stalking case. Thus, they are of great importance when trying to identify factors contributing to stalking duration. The present study aims to identify distinct subgroups of stalking victims based on measures of behavioral stalking dimensions. These victim subgroups, stalking dimensions, and victim-stalker relationship are examined in relation to stalking duration. Using a sample of 137 university students, latent profile analysis (LPA) revealed five distinct victim subgroups based on stalker behavior dimensions: surveillance, low-profile, social lurker, wide scope, and baseline stalkers. The subgro…

05 social sciencesPoison controlHuman factors and ergonomics16. Peace & justiceSuicide preventionOccupational safety and healthPathology and Forensic MedicineLurkerForensic psychologyInjury prevention050501 criminologyGenetics0501 psychology and cognitive sciencesPsychologySocial psychologyStalking050104 developmental & child psychology0505 lawClinical psychologyJournal of Forensic Sciences
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ERP correlates of masked affective priming with emoticons

2013

Emoticons seem to enrich computer-mediated communication by improving enjoyment, perceived richness and usefulness of information (Huang, Yen, & Zhang, 2008). Despite their extensive use over the last decades, the way emoticons affect subsequent emotional/cognitive processing is not fully understood. Here we conducted a masked priming experiment that explored the time course of the masked affective priming effect while recording event-related potentials. Type of prime (emoticon vs. word) and prime valence (positive vs. negative) were manipulated to assess their influence in the processing of positive/negative target words. Results showed a masked affective priming effect in early (N2) and l…

05 social sciencesZhàngCognitionAffective priming050105 experimental psychologyDevelopmental psychologyHuman-Computer Interaction03 medical and health sciences0302 clinical medicineArts and Humanities (miscellaneous)Time course0501 psychology and cognitive sciencesEmoticonValence (psychology)Psychology030217 neurology & neurosurgeryGeneral PsychologyComputers in Human Behavior
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Signs activate their written word translation in deaf adults: An ERP study on cross-modal co-activation in German Sign Language

2020

Since signs and words are perceived and produced in distinct sensory-motor systems, they do not share a phonological basis. Nevertheless, many deaf bilinguals master a spoken language with input merely based on visual cues like mouth representations of spoken words and orthographic representations of written words. Recent findings further suggest that processing of words involves cross-language cross-modal co-activation of signs in deaf and hearing bilinguals. Extending these findings in the present ERP-study, we recorded the electroencephalogram (EEG) of fifteen congenitally deaf bilinguals of German Sign Language (DGS) (native L1) and German (early L2) as they saw videos of semantically a…

050101 languages & linguisticsLinguistics and LanguageGerman Sign LanguageSign languagesign language; phonology; priming; EEG; bimodal bilingualismLanguage and LinguisticsSentence processingGerman030507 speech-language pathology & audiology03 medical and health sciencessign languagesign language linguistics psycholinguistics0501 psychology and cognitive sciencesprimingLanguage. Linguistic theory. Comparative grammarP101-41005 social sciencesBimodal bilingualismPhonologylanguage.human_languageLinguisticsphonologybimodal bilingualismlanguageeeg0305 other medical sciencePsychologyPriming (psychology)Spoken languageGlossa: a journal of general linguistics
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