Search results for "RIMI"
showing 10 items of 3981 documents
Dynamics of BCR-ABL mRNA expression in first-line therapy of chronic myelogenous leukemia patients with imatinib or interferon alpha/ara-C.
2003
We sought to determine dynamics of BCR-ABL mRNA expression levels in 139 patients with chronic myelogenous leukemia (CML) in early chronic phase, randomized to receive imatinib (n=69) or interferon (IFN)/Ara-C (n=70). The response was sequentially monitored by cytogenetics from bone marrow metaphases (n=803) and qualitative and quantitative RT-PCR from peripheral blood samples (n=1117). Complete cytogenetic response (CCR) was achieved in 60 (imatinib, 87%) vs 10 patients (IFN/Ara-C, 14%) after a median observation time of 24 months. Within the first year after CCR, best median ratio BCR-ABL/ABL was 0.087%, (imatinib, n=48) vs 0.27% (IFN/Ara-C, n=9, P=0.025). BCR-ABL was undetectable in 25 c…
Role of the cerebellum in time perception: A TMS study in normal subjects
2007
The aim of this study was to investigate the role of the cerebellum in a temporal-discrimination task without movement production in healthy subjects. Ten healthy subjects underwent a time-perception task with somatosensory stimuli. Two pairs of electrical stimuli: the first considered the reference pair (rp) with a standard interval of 400 ms and the second, the test pair (tp), with variable intervals ranging from 300 to 500 ms, were applied by surface electrodes on the right forearm. Subjects were instructed to compare time intervals of rp and tp and to estimate whether the tp interval was shorter than, equal to, or longer than that of rp. The task was performed in baseline and after 1 Hz…
Multimethod prediction of child abuse risk in an at-risk sample of male intimate partner violence offenders
2016
Abstract The vast majority of research on child abuse potential has concentrated on women demonstrating varying levels of risk of perpetrating physical child abuse. In contrast, the current study considered factors predictive of physical child abuse potential in a group of 70 male intimate partner violence offenders, a group that would represent a likely high risk group. Elements of Social Information Processing theory were evaluated, including pre-existing schemas of empathy, anger, and attitudes approving of parent-child aggression considered as potential moderators of negative attributions of child behavior. To lend methodological rigor, the study also utilized multiple measures and mult…
Topicality matters: Position-specific demands on Chinese discourse processing
2011
We report an event-related potential study designed to explore the nature of context-induced topicality in Chinese discourse processing. Topic is what an utterance is about and represents the most prominent discourse element, which occurs sentence-initially in Chinese. We tested question-answer pairs consisting of topic and non-topic questions followed by different continuations (Topic-Continuity, Topic-Shift, Novel-Topic). ERPs were measured at distinct sentential positions and revealed that sentence-initially information processing is guided by topicality, which affects N400 and Late Positivity effects alike. In non-initial positions, the given-new distinction is the dominant principle, a…
A new approach to examine the relationships between sensory and gas chromatography-olfactometry data using generalized procrustes analysis applied to…
2003
Six French Chardonnay wines were submitted to both sensory and combined headspace/gas chromatography-olfactometry analyses. The detection frequencies allowed five hierarchical levels to be distinguished: P25, the odorant areas (OAs) having a detection frequencyor =25% (the complete olfactogram without the odor noise); P40,or =40%; P55,or =55%; P70,or =70%; and P85,or =85%. Moreover, the detection frequencies were analyzed to distinguish 21 discriminative OAs. Wines tested by sensory analysis and the headspace samples analyzed by gas chromatography-olfactometry (GC-O) were described by a heterogeneous vocabulary distributed into nine overall classes of descriptors. The new statistical treatm…
Numbers and time doubly dissociate
2011
The magnitude dimensions of number, time and space have been suggested to share some common magnitude processing, which may imply symmetric interaction among dimensions. Here we challenge these suggestions by presenting a double dissociation between two neuropsychological patients with left (JT) and right (CB) parietal lesions and selective impairment of number and time processing respectively. Both patients showed an influence of task-irrelevant number stimuli on time but not space processing. In JT otherwise preserved time processing was severely impaired in the mere presence of task-irrelevant numbers, which themselves could not be processed accurately. In CB, impaired temporal estimatio…
Early use of phonological codes in deaf readers: An ERP study.
2017
Previous studies suggest that deaf readers use phonological information of words when it is explicitly demanded by the task itself. However, whether phonological encoding is automatic remains controversial. The present experiment examined whether adult congenitally deaf readers show evidence of automatic use of phonological information during visual word recognition. In an ERP masked priming lexical decision experiment, deaf participants responded to target words preceded by a pseudohomophone (koral - CORAL) or an orthographic control prime (toral - CORAL). Responses were faster for the pseudohomophone than for the orthographic control condition. The N250 and N400 amplitudes were reduced fo…
Early access to abstract representations in developing readers: evidence from masked priming
2013
A commonly shared assumption in the field of visual-word recognition is that retinotopic representations are rapidly converted into abstract representations. Here we examine the role of visual form vs. abstract representations during the early stages of word processing - as measured by masked priming - in young children (3rd and 6th Graders) and adult readers. To maximize the chances of detecting an effect of visual form, we employed a language with a very intricate orthography, Arabic. If visual form plays a role in the early stages of processing, greater benefit would be expected from related primes that have the same visual form (in terms of the ligation pattern between a word's letters)…
Effect of Practice, Mapping, Stimulus and Size on String Matching
1987
The same-different discrepancy on a matching task on which the subject had to determine the number of common elements (physically identical and appearing in the same position) between two strings of size 1 to 4 was investigated. Manipulated also were the type of presentation (fixed or varied sets), amount of practice (four blocks), and type of stimulus (letters, words). Reaction times for pure positive responses (all same at each level) were faster than negative responses (all different), confirming the usual discrepancy shown in previous studies. The discrepancy was smaller for well-learned sets (fixed sets) and for words, indicating the development of a comparison process based on global…
More on magnitude of priming in implicit memory tasks.
2002
The effects of word frequency, length of the word, and type of word Fragment in a fragment-completion test were investigated with 57 undergraduate students, 19–22 years. Priming with better performance on studied than on nonstudied words in this task was greater for low frequency words than for high frequency words and greater for fragments without the first letter than for fragments with the first letter. It was inferred that characteristics of fragments should be considered in any implicit memory task when the magnitude of priming is of interest. In general, word fragment-completion processes appear to be based on sources of information available in visual identification tasks.