Search results for "RIP"
showing 10 items of 9780 documents
Transcriptional study of photoperiodic response in aphids and characterization of candidate photoperiodic photoreceptors
2020
Acyrthosiphon pisum es una especie de pulgón altamente estacional. Durante la estación favorable, únicamente se producen hembras partenogenéticas vivíparas (virginóparas). En otoño, cuando hay menos luz (el fotoperiodo es más corto), A. pisum percibe la diferencia y las virginóparas paren machos y luego hembras sexuadas (ovíparas). Tras aparearse, las ovíparas ponen huevos que resisten el invierno y eclosionan en primavera, reiniciando el ciclo. Algunos mutantes que ocurren de forma natural no responden al fotoperiodo y se reproducen asexualmente durante todo el año. Se denominan anholocíclicos en contraposición a los holocíclicos, que tienen fase sexual. Se desconocen los mecanismos molecu…
Synthesis, characterization, and cellular investigations of porphyrin– and chlorin–indomethacin conjugates for photodynamic therapy of cancer
2021
Indomethacin is a potent non-steroidal anti-inflammatory drug (NSAID) with a strong selective inhibitor activity towards cyclooxygenase-2 (COX-2), an enzyme that is highly overexpressed in various tumour cells, being involved in tumourigenesis. Concomitantly, porphyrins have gained much attention as promising photosensitizers (PSs) for the non-invasive photodynamic therapy (PDT) of cancer. Herein, we report the design, and determine the singlet oxygen generation capacity and in vitro cellular toxicity of porphyrin- and chlorin-indomethacin conjugates (P2-Ind and C2-Ind). Both the conjugates were obtained in high yields and were characterized by 1H, 19F and 13C NMR as well as by high resolut…
Early evolutionary colocalization of the nuclear ribosomal 5S and 45S gene families in seed plants: evidence from the living fossil gymnosperm Ginkgo…
2012
In seed plants, the colocalization of the 5S loci within the intergenic spacer (IGS) of the nuclear 45S tandem units is restricted to the phylogenetically derived Asteraceae family. However, fluorescent in situ hybridization (FISH) colocalization of both multigene families has also been observed in other unrelated seed plant lineages. Previous work has identified colocalization of 45S and 5S loci in Ginkgo biloba using FISH, but these observations have not been confirmed recently by sequencing a 1.8 kb IGS. In this work, we report the presence of the 45S–5S linkage in G. biloba, suggesting that in seed plants the molecular events leading to the restructuring of the ribosomal loci are much o…
Liikunnanopettajaksi vuosina 1984 - 2004 valmistuneiden työtyytyväisyys
2012
Tutkimuksen tarkoituksena oli selvittää liikunnanopettajiksi vuosina 1984–2004 valmistuneiden työtyytyväisyyttä ja siihen vaikuttavia tekijöitä. Tutkimukseen osallistui yhteensä 621 liikunnanopettajan ammatissa toimivaa henkilöä (naisia 326, miehiä 295). Tutkimus suoritettiin strukturoiduilla kyselylomakkeilla vastavalmistuneille liikunnanopettajille vuonna 2008 sekä kokeneemmille liikunnanopettajille vuonna 2009. Tutkimusaineiston analysointiin käytettiin t-testiä sekä yksi- ja kaksisuuntaista varianssianalyysia. Pääkomponenttianalyysinn avulla työtyytyväisyyttä muodostavat tekijät luokiteltiin kuuteen eri komponenttiin. Tutkimuksen tulokset osoittivat, että 80 prosenttia liikunnanopettaji…
Physical and Quality of Life Changes in Elderly Patients after Laparoscopic Surgery for Colorectal Cancer—A Prospective Cohort Study
2022
Background—The incidence of colorectal cancer is increasing among elderly people, where postoperative complications are frequent. Methods—We evaluated postoperative physical and quality of life changes in elderly patients undergoing laparoscopic surgery for colorectal cancer. A prospective cohort study was performed in 31 colorectal cancer patients ≥60 years who were scheduled for laparoscopic surgery due to colorectal cancer. Outcomes were measured one month preoperative (T1), three days postoperative (T2) and one month postoperative (T3). Results—The largest early postoperative (from T1 to T2) declines were observed for isometric knee extension strength (33.1%), 30 s …
Characterization and transcription studies of a phytochelatin synthase gene from the solitary tunicate Ciona intestinalis exposed to cadmium.
2014
The major thiol-containing molecules involved in controlling the level of intracellular ROS in eukaryotes, acting as a nonenzymatic detoxification system, are metallothioneins (MTs), glutathione (GSH) and phytochelatins (PCs). Both MTs and GSH are well-known in the animal kingdom. PC was considered a prerogative of the plant kingdom but, in 2001, a phytochelatin synthase (PCS) gene was described in the nematode Caenorhabditis elegans; additional genes encoding this enzyme were later described in the earthworm Eisenia fetida and in the parasitic nematode Schistosoma mansoni but scanty data are available, up to now, for Deuterostomes. Here, we describe the molecular characteristics and transc…
I piani nazionali di ripresa e resilienza in prospettiva comparata
2021
L’articolo propone un’analisi dei piani di ripresa e resilienza di Francia, Germania, Italia, Spagna, Grecia e Portogallo. Per ogni caso di studio si prendono in considerazione vari elementi. Innanzitutto, è oggetto di disamina il contesto economico nel quale è calato il singolo piano, con un approfondimento sull’impatto della pandemia sulle finanze di ciascun Paese. Successivamente, si dà conto delle dimensioni e delle caratteristiche del piano. In particolare, si esaminano la portata finanziaria complessiva del piano, i settori in cui sono concentrate le risorse, la ripartizione dei finanziamenti previsti tra sovvenzioni e prestiti. Si ricostruisce, inoltre, il modello di governance di og…
Noziedzīgi iegūtu līdzekļu legalizēšanas pierādīšanas problemātika kriminālprocesā
2022
Noziedzīgi iegūtu līdzekļu legalizācija ir globāla problēma. Tā visu laiku mainās un attīstās, jo veidi, kādos noziedznieki legalizē noziedzīgi iegūtus līdzekļus, arī konstanti attīstās, tiem paliekot arvien radošākiem un sarežģītākiem. Pēdējos gados veiktie normatīvo aktu grozījumi attiecībā uz noziedzīgi iegūtu līdzekļu legalizācijas pierādīšanu situāciju nepadara vienkāršāku, bet “atver durvis” jaunām problēmām, piemēram, iespējamiem nevainīguma prezumpcijas pārkāpumiem. Mūsdienās būtiska loma ir arī jaunajām tehnoloģijām noziedzīgi iegūtu līdzekļu legalizācijā un to radītajām sekām. Darbā tiek aplūkotas aktuālākās legalizācijas pierādīšanas problēmas, tas ir: pierādīšanas standarts, pie…
Cold Exposure Affects Lipid Metabolism, Fatty Acids Composition and Transcription in Pig Skeletal Muscle
2021
Cold exposure promotes glucose oxidation and modulates the lipid metabolism in adipose tissue, but it is still not fully clear whether cold exposure could affect meat quality and fatty acid metabolism in skeletal muscle of pig in vivo. Here, we kept finishing pigs under cold or room temperature overnight and determined the effects of cold exposure on meat quality, fatty acids composition and transcriptional changes in skeletal muscle of pigs. We found that cold exposure significantly reduced the meat colour24 h and pH24 h, without affecting carcass characteristics and other meat quality traits. Considerable changes were found in the proportions of individual fatty acids and the total conten…
¿Una herencia incómoda? Percepciones del patrimonio islámico peninsular en el mundo moderno (siglos XV-XVII)
2022
El propósito de esta tesis es dar respuesta a si hubo una intención manifiesta por parte de los cristianos del antiguo Reino de Valencia por borrar la huella de la presencia islámica tras la toma de Balansiya, ya que apenas se conservan a día de hoy vestigios de su pasado, de ahí la primera parte del título de nuestro trabajo: ¿Una herencia incómoda? A través de una revisión bibliográfica y de documentación de archivo analizamos si se produjo verdaderamente tal rechazo tras la conquista de Šarq al-Andalus, a la vez que mostramos un estudio comparativo con lo sucedido en otras partes del territorio peninsular. Todo ello en un marco cronológico que se inicia con la conquista de Granada y fina…