Search results for "RITU"

Treatment of multiple sclerosis with rituximab: A multicentric Italian–Swiss experience

2020

Background: Rituximab, an anti-CD20 monoclonal antibody leading to B lymphocyte depletion, is increasingly used as an off-label treatment option for multiple sclerosis (MS). Objective: To investigate the effectiveness and safety of rituximab in relapsing–remitting (RR) and progressive MS. Methods: This is a multicenter, retrospective study on consecutive MS patients treated off-label with rituximab in 22 Italian and 1 Swiss MS centers. Relapse rate, time to first relapse, Expanded Disability Status Scale (EDSS) progression, incidence of adverse events, and radiological outcomes from 2009 to 2019 were analyzed. Results: A total of 355/451 enrolled subjects had at least one follow-up visit an…

Orphan symptoms in advanced cancer patients followed at home

2013

Abstract Orphan symptoms are rarely assessed, particularly at home. The aim of this multicenter prospective study was to assess the prevalence of these symptoms and eventual factors possibly associated in advanced cancer patients at admission of a home care program. A prospective study was performed at three home care programs in Italy. Patients' data were collected, including age, sex, diagnosis, and Karnofsky status. Possible contributing factors were analyzed; preexisting neurological diseases, cerebral metastases, hyperthermia, diabetes, a state of dehydration clinically evident and/or oliguria, possible biochemical parameters when available, data regarding recent chemotherapy, opioids …

La rencontre entre Thérèse d'Avila et Francisco de Osuna autour du Recueillement: des "Abécédaires spirituels" au "Livre des Demeures"

2015

International audience; A l’occasion de cette communication, je me propose d’aborder le thème de la rencontre entre Thérèse d’Avila et un de ses maîtres spirituels indirects, le Franciscain andalou Francisco de Osuna. C’est à travers la lecture du Troisième Abécédaire spirituel (1527) ―ouvrage rédigé dans un contexte polémique marqué par la récente condamnation de l’illuminisme par l’Inquisition de Tolède (1525)― que la jeune Thérèse s’est initiée en 1538 à l’oraison de Recueillement. Après une présentation rapide de la vie et de l’œuvre prolifique ―Abécédaires castillans et sermonnaires latins― de ce maître spirituel et prédicateur très apprécié au XVIème siècle, je tâcherai de donner une …

How to Sell SaaS: A Model for Main Factors of Marketing and Selling Software-as-a-Service

2011

Software-as-a-Service providers have been growing fast while the contemporary research literature has neglected analysis of their business-critical marketing and sales processes. In this paper we collect the key factors characterizing how to market and sell SaaS to business customers into an eight dimensional model. We also use an explorative multi-case study to observe six SaaS providers and validate the model. The interviewed providers emphasized use of the Internet for marketing communication while personal direct sale was the dominating sales approach. Customer acquisition cost was the key performance indicator for marketing and sales while customer lifetime value and churn were the KPI…

The representation of work in the French narration since the Thirty Glorious Years

2017

There has been a resurgence of interest in the theme of work, since the end of the Thirty Glorious Years. Initially centered on a few emblematic works, there has emerged in subsequent years, multifaceted forms of expression that do not lend themselves easily to unifying categorisation. However, a specific literariness has emerged on this theme that reflects an originality that is unique within the realm of literary production. Whilst all writers hesitate about the best means to narrate human activities, those who write about work face particular difficulties in defining their position and status. The notion of fiction itself is challenged as it shifts between the domain of the real and the …

E nasciu lu Bammineddu. Testi e contesti del Natale in Sicilia

2019

Il Natale, dopo la Pasqua, è la più significativa occasione di ricostruzione e riaffermazione della comunità cristiana, momento di commemorazione dell’apertura di un tempo nuovo sul piano teologico, momento di attualizzazione, potrebbe ben dirsi di ripetizione, di un evento fondativo dei cicli del tempo e della vita sul piano del vissuto ossia delle credenze e delle prassi rituali. Il Natale cristiano, d’altronde, nel recuperare forme cerimoniali pre-cristiane, si è costituito, a livello popolare e non solo popolare, come una festa di rinascita dell’anno, come un rito inteso ad auspicare e provocare la rinascita della natura nel momento della crisi invernale. Tale profonda e densa stratific…

Haunted Bodies and Scientific Discourse in Neo-Victorian Fiction. The case of Roberts's in the red kitchen

2013

Copiste et créateur : les paradoxes de l'écrivain romantique

2015

International audience; L’article analyse deux célèbres figures de copistes romantiques, celle d'Anselme, le héros du Vase d'or de Hoffmann (1814), et celle d'Akaki Akakiévitch, le héros du Manteau de Gogol (1843). Il s’interroge sur le rapport entre copie et création à l’époque romantique.

Norme sulla tutela dell'ambiente nelle poleis greche di età pre-ellenistica

2020

This paper offers a study of fifth- and fourth-century BC epigraphical and literary documents pertaining to what we may call ‘ancient ecology’. Even though documents are not many, there is proof of laws governing cleanness and decorum of Greek cities’ public space. From the evidence it is possible to state that city institutions intervened on this matter only in few and ‘exceptional’ cases, with the aim of preventing that some particular areas of the city, which were of primary importance for the community life, got dirty. Citizens were subject to fines, if they threw in public spaces (i.e. streets) animal and human waste, or craftwork activities’. In particular, inscriptions from Athens an…

Safety and clinical activity of a combination therapy comprising two antibody-based targeting agents for the treatment of non-Hodgkin lymphoma: resul…

2013

Purpose Inotuzumab ozogamicin (INO) is an antibody-targeted chemotherapy agent composed of a humanized anti-CD22 antibody conjugated to calicheamicin, a potent cytotoxic agent. We performed a phase I/II study to determine the maximum-tolerated dose (MTD), safety, efficacy, and pharmacokinetics of INO plus rituximab (R-INO) for treatment of relapsed/refractory CD20+/CD22+ B-cell non-Hodgkin lymphoma (NHL). Patients and Methods A dose-escalation phase to determine the MTD of R-INO was followed by an expanded cohort to further evaluate the efficacy and safety at the MTD. Patients with relapsed follicular lymphoma (FL), relapsed diffuse large B-cell lymphoma (DLBCL), or refractory aggressive NH…