Search results for "RIZ"

Proton magnetic resonance imaging with para-hydrogen induced polarization.

2012

A major challenge in imaging is the detection of small amounts of molecules of interest. In the case of magnetic resonance imaging (MRI) their signals are typically concealed by the large background signal of e.g. the body. This problem can be tackled by hyperpolarization which increases the NMR signals up to several orders of magnitude. However, this strategy is limited for (1)H, the most widely used nucleus in NMR and MRI, because the enormous number of protons in the body screens the small amount of hyperpolarized ones. Here, we describe a method giving rise to high (1)H MRI contrast for hyperpolarized molecules against a large background signal. The contrast is based on the J-coupling i…

Identical fits of nonnegative matrix/tensor factorization may correspond to different extracted event-related potentials

2010

Nonnegative Matrix / Tensor factorization (NMF/NTF) have been used in the study of EEG, and the fit (explained variation) is often used to evaluate the performance of a nonnegative decomposition algorithm. However, this parameter only reveals the information derived from the mathematical model and just exhibits the reliability of the algorithms, and the property of EEG can not be reflected. If fits of two algorithms are identical, it is necessary to examine whether the desired components extracted by them are identical too. In order to verify this doubt, we performed NMF and NTF on the same dataset of an auditory event-related potentials (ERPs), and found that the identical fits of NMF and …

Evaluation of MRI and cannabinoid type 1 receptor PET templates constructed using DARTEL for spatial normalization of rat brains

2015

Purpose: Image registration is one prerequisite for the analysis of brain regions in magnetic-resonance-imaging (MRI) or positron-emission-tomography (PET) studies. Diffeomorphic anatomical registration through exponentiated Lie algebra (DARTEL) is a nonlinear, diffeomorphic algorithm for image registration and construction of image templates. The goal of this small animal study was (1) the evaluation of a MRI and calculation of several cannabinoid type 1 (CB1) receptor PET templates constructed using DARTEL and (2) the analysis of the image registration accuracy of MR and PET images to their DARTEL templates with reference to analytical and iterative PET reconstruction algorithms. Methods:…

Letters to the editor

1992

Increasing Stability of EEG Components Extraction Using Sparsity Regularized Tensor Decomposition

2018

Tensor decomposition has been widely employed for EEG signal processing in recent years. Constrained and regularized tensor decomposition often attains more meaningful and interpretable results. In this study, we applied sparse nonnegative CANDECOMP/PARAFAC tensor decomposition to ongoing EEG data under naturalistic music stimulus. Interesting temporal, spectral and spatial components highly related with music features were extracted. We explored the ongoing EEG decomposition results and properties in a wide range of sparsity levels, and proposed a paradigm to select reasonable sparsity regularization parameters. The stability of interesting components extraction from fourteen subjects’ dat…

Extract Mismatch Negativity and P3a through Two-Dimensional Nonnegative Decomposition on Time-Frequency Represented Event-Related Potentials

2010

This study compares the row-wise unfolding nonnegative tensor factorization (NTF) and the standard nonnegative matrix factorization (NMF) in extracting time-frequency represented event-related potentials—mismatch negativity (MMN) and P3a from EEG under the two-dimensional decomposition The criterion to judge performance of NMF and NTF is based on psychology knowledge of MMN and P3a MMN is elicited by an oddball paradigm and may be proportionally modulated by the attention So, participants are usually instructed to ignore the stimuli However the deviant stimulus inevitably attracts some attention of the participant towards the stimuli Thus, P3a often follows MMN As a result, if P3a was large…

Repurposing of the ALK inhibitor crizotinib for acute leukemia and multiple myeloma cells

2021

Crizotinib was a first generation of ALK tyrosine kinase inhibitor approved for the treatment of ALK-positive non-small-cell lung carcinoma (NSCLC) patients. COMPARE and cluster analyses of transcriptomic data of the NCI cell line panel indicated that genes with different cellular functions regulated the sensitivity or resistance of cancer cells to crizotinib. Transcription factor binding motif analyses in gene promoters divulged two transcription factors possibly regulating the expression of these genes, i.e., RXRA and GATA1, which are important for leukemia and erythroid development, respectively. COMPARE analyses also implied that cell lines of various cancer types displayed varying degr…

Development and biological investigations of hypoxia-sensitive prodrugs of the tyrosine kinase inhibitor crizotinib

2019

Despite the huge success of tyrosine kinase inhibitors as anticancer agents, severe side effects are a major problem. In order to overcome this drawback, the first hypoxia-activatable 2-nitroimidazole-based prodrugs of the clinically approved ALK and c-MET inhibitor crizotinib were developed. The 2-aminopyridine functionality of crizotinib (essential for target kinase binding) was considered as ideal position for prodrug derivatization. Consequently, two different prodrugs were synthesized with the nitroimidazole unit attached to crizotinib either via carbamoylation (A) or alkylation (B) of the 2-aminopyridine moiety. The successful prodrug design could be proven by docking studies and a dr…

Electrocardiographic Indices of Left Ventricular Hypertrophy and Repolarization Phase Share the Same Genetic Influences: A Twin Study

2009

Background: Both left ventricular hypertrophy (LVH) and repolarization phase (RP) are known to be attributable to genetic influences, but less is known whether they share same genetic influences. The aim of this study was to investigate to what extent individual differences in electrocardiographic (ECG) LVH and RP are explained by genetic and environmental influences and whether these influences are shared between these two traits. Methods: Resting ECG recordings were obtained from 186 monozygotic and 203 dizygotic female twin individuals, aged 63 to 76 years. Latent factors, called LVH and RP, were formed to condense the information obtained from LVH indices (Cornell voltage and Cornell pr…

Mirizzi syndrome type V complicated with both cholecystobiliary and cholecystocolic fistula: a case report

2021

Abstract Mirizzi syndrome (MS) is a common bile duct (CBD) obstruction caused by extrinsic compression from an impacted stone in the cystic duct or infundibulum of the gallbladder. Patients affected by MS may present abdominal pain and jaundice. A 37-year-old male with neurologic residuals post-encephalitis arrived at the emergency department reporting abdominal pain, jaundice and fever. An ultrasound of the abdomen identified cholecystolithiasis with a dilated CBD. He did not undergo CT or MRI due to poor compliance and parents’ disagreement. Eventually, they accepted to perform endoscopic retrograde cholangiopancreatography, which diagnosed MS with both cholecystobiliary and cholecystocol…