Search results for "RL"
showing 10 items of 13546 documents
Indicaxanthin inhibits NADPH oxidase (NOX)-1 activation and NF-κB-dependent release of inflammatory mediators and prevents the increase of epithelial…
2014
Dietary redox-active/antioxidant phytochemicals may help control or mitigate the inflammatory response in chronic inflammatory bowel disease (IBD). In the present study, the anti-inflammatory activity of indicaxanthin (Ind), a pigment from the edible fruit of cactus pear (Opuntia ficus-indica, L.), was shown in an IBD model consisting of a human intestinal epithelial cell line (Caco-2 cells) stimulated by IL-1β, a cytokine known to play a major role in the initiation and amplification of inflammatory activity in IBD. The exposure of Caco-2 cells to IL-1β brought about the activation of NADPH oxidase (NOX-1) and the generation of reactive oxygen species (ROS) to activate intracellular signal…
Prosodia y partículas discursivas: sobre las funciones de atenuación, intensificación como valores (des)corteses en los marcadores conversacionales
2015
La presente investigación se integra en un proyecto más amplio, Fonocortesía: el componente fónico en la expresión de cortesía y descortesía verbales en español coloquial (Ministerio de Economía y Competitividad, FFI2009-07034), interesado en el estudio de la capacidad del componente fónico (a nivel segmental y suprasegmental) para favorecer efectos pragmáticos corteses o descorteses en la conversación coloquial. Dentro de esa línea investigación general, pretendemos analizar aquí la variedad de realizaciones prosódicas de los denominados enfocadores de la alteridad, y las implicaciones que ello pueda tener en la asunción de efectos pragmáticos (des)corteses, articulados principalmente a tr…
Uncertainty quantification on a spatial Markov-chain model for the progression of skin cancer
2019
AbstractA spatial Markov-chain model is formulated for the progression of skin cancer. The model is based on the division of the computational domain into nodal points, that can be in a binary state: either in ‘cancer state’ or in ‘non-cancer state’. The model assigns probabilities for the non-reversible transition from ‘non-cancer’ state to the ‘cancer state’ that depend on the states of the neighbouring nodes. The likelihood of transition further depends on the life burden intensity of the UV-rays that the skin is exposed to. The probabilistic nature of the process and the uncertainty in the input data is assessed by the use of Monte Carlo simulations. A good fit between experiments on mi…
Norm, essential norm and weak compactness of weighted composition operators between dual Banach spaces of analytic functions
2017
Abstract In this paper we estimate the norm and the essential norm of weighted composition operators from a large class of – non-necessarily reflexive – Banach spaces of analytic functions on the open unit disk into weighted type Banach spaces of analytic functions and Bloch type spaces. We also show the equivalence of compactness and weak compactness of weighted composition operators from these weighted type spaces into a class of Banach spaces of analytic functions, that includes a large family of conformally invariant spaces like BMOA and analytic Besov spaces.
Cáncer en los primeros 18 meses de vida
2020
Resumen: Introducción: La enfermedad oncohematológica continúa siendo la primera causa de mortalidad no traumática en la infancia y una importante causa de morbilidad. El paciente menor de 18 meses presenta particularidades clínicas, diagnósticas y terapéuticas que es interesante conocer por todo pediatra, con el fin de lograr una mayor supervivencia y una menor comorbilidad a lo largo de su vida. Material y métodos: Estudio descriptivo retrospectivo de variables clínicas, diagnósticas y terapéuticas en pacientes menores de 18 meses diagnosticados de enfermedad oncohematológica que reciben quimioterapia en una unidad de oncología pediátrica entre enero 2007 y agosto 2019. Resultados: Setent…
Intratumoral Heterogeneity in EGFR-Mutant NSCLC Results in Divergent Resistance Mechanisms in Response to EGFR Tyrosine Kinase Inhibition
2015
Abstract Non–small cell lung cancers (NSCLC) that have developed resistance to EGF receptor (EGFR) tyrosine kinase inhibitor (TKI), including gefitinib and erlotinib, are clinically linked to an epithelial-to-mesenchymal transition (EMT) phenotype. Here, we examined whether modulating EMT maintains the responsiveness of EGFR-mutated NSCLCs to EGFR TKI therapy. Using human NSCLC cell lines harboring mutated EGFR and a transgenic mouse model of lung cancer driven by mutant EGFR (EGFR-Del19-T790M), we demonstrate that EGFR inhibition induces TGFβ secretion followed by SMAD pathway activation, an event that promotes EMT. Chronic exposure of EGFR-mutated NSCLC cells to TGFβ was sufficient to ind…
Transformative Teaching and Learning Through Engaged Practice : Lecturers’ and Students’ Experiences in a University and Underserved Community Partne…
2018
peer-reviewed The Community Wellness, Empowerment, Leadership and Lifeskills (CWell) program is a two-year community-driven program developed in partnership between an underserved-community in Limerick City, and staff at the University of Limerick (UL), Ireland. This paper explores the transformative teaching and learning experiences that arose throughout the duration of the progam for the lecturers and students. Data were collected through interviews and focus groups with lecturers and students involved in the program. Students supported the notion of “learning differently” and focused around prior learning and attitude to learning, learning about learning and impact of learning. Lecturers…
With children in their lived place: children's action as research data
2012
Abstract This article discusses theory and methods of researching the everyday experiences of children in the city environment combined with the question of giving a voice to children. The article is organised into three parts. Part one provides a conceptual background, theorising the relational as well as intergenerational character of the concept of environment. The cultural-geographical theory and the concept of Thirdspace are used. Part two illustrates the theoretical and methodological themes with reference to my study with children. I explored the encounter between children and the urban environment. I applied ethnographic tours around a city block with children and the children's spo…
AN IL-6/IL-6 SOLUBLE RECEPTOR (IL-6R) HYBRID PROTEIN (H-IL-6) INDUCES EPO-INDEPENDENT ERYTHROID DIFFERENTIATION IN HUMAN CD34+CELLS
2000
H-IL-6 is a hybrid protein constructed to contain IL-6 and its soluble receptor linked by a flexible peptide chain. Here we show that H-IL-6 strongly enhances proliferation of human CD34(+)cells in serum-free liquid culture, and that the majority of the cells generated belong to the erythroid lineage, being positive for the marker Glycophorin A. Conversely, H-IL-6 does not increase the number of myeloid, CD13-positive cells. Comparable effects are observed on progenitors from cord blood and adult peripheral blood. Therefore, H-IL-6 triggers an erythroid-inducing signal in haematopoietic progenitor cells, independently from erythropoietin (EPO).
Watermarking for ontologies
2011
In this paper, we study watermarking methods to prove the ownership of an ontology. Different from existing approaches, we propose to watermark not by altering existing statements, but by removing them. Thereby, our approach does not introduce false statements into the ontology. We show how ownership of ontologies can be established with provably tight probability bounds, even if only parts of the ontology are being re-used. We finally demonstrate the viability of our approach on real-world ontologies.