Search results for "RLS"

Cardiolipin synthesis in brown and beige fat mitochondria is essential for systemic energy homeostasis

2018

Summary Activation of energy expenditure in thermogenic fat is a promising strategy to improve metabolic health, yet the dynamic processes that evoke this response are poorly understood. Here we show that synthesis of the mitochondrial phospholipid cardiolipin is indispensable for stimulating and sustaining thermogenic fat function. Cardiolipin biosynthesis is robustly induced in brown and beige adipose upon cold exposure. Mimicking this response through overexpression of cardiolipin synthase (Crls1) enhances energy consumption in mouse and human adipocytes. Crls1 deficiency in thermogenic adipocytes diminishes inducible mitochondrial uncoupling and elicits a nuclear transcriptional respons…

A TRAPPC6B splicing variant associates to restless legs syndrome

2016

Abstract INTRODUCTION: RLS is a common movement disorders with a strong genetic component in its pathophysiology, but, up to now, no causative mutation has been reported. METHODS: We re-evaluated the previously described RLS2 family by exome sequencing. RESULTS: We identified fifteen variations in the 14q critical region. The c.485G > A transition of the TRAPPC6B gene segregates with the RLS2 haplotype, is absent in 200 local controls and is extremely rare in 12988 exomes from the Exome Variant Server (EVS). This variant alters a splicing site and hampers the normal transcript processing by promoting exon 3-skipping as demonstrated by minigene transfection and by patient transcripts. CON…

Association of leisure time physical activity and NMR-detected circulating amino acids in peripubertal girls: A 7.5-year longitudinal study

2017

AbstractThis study investigated the longitudinal associations of physical activity and circulating amino acids concentration in peripubertal girls. Three hundred ninety-six Finnish girls participated in the longitudinal study from childhood (mean age 11.2 years) to early adulthood (mean age 18.2 years). Circulating amino acids were assessed by nuclear magnetic resonance spectroscopy. LTPA was assessed by self-administered questionnaire. We found that isoleucine, leucine and tyrosine levels were significantly higher in individuals with lower LTPA than their peers at age 11 (p < 0.05 for all), independent of BMI. In addition, isoleucine and leucine levels increased significantly (~15%) fro…

Relationship between age and elite marathon race time in world single age records from 5 to 93 years

2013

International audience; Background:The aims of the study were (i) to investigate the relationship between elite marathon race times andage in 1-year intervals by using the world single age records in marathon running from 5 to 93 years and (ii)toevaluate the sex difference in elite marathon running performance with advancing age.Methods:World single age records in marathon running in 1-year intervals for women and men were analysedregarding changes across age for both men and women using linear and non-linear regression analyses for eachage for women and men.Results:The relationship between elite marathon race time and age was non-linear (i.e.polynomial regression 4thdegree) for women and m…

Indefinite integrals involving the incomplete elliptic integrals of the first and second kinds

2016

ABSTRACTA substantial number of indefinite integrals are presented for the incomplete elliptic integrals of the first and second kinds. The number of new results presented is about three times the total number to be found in the current literature. These integrals were obtained with a Lagrangian method based on the differential equations which these functions obey. All results have been checked numerically with Mathematica. Similar results for the incomplete elliptic integral of the third kind will be presented separately.

Indefinite integrals involving the incomplete elliptic integral of the third kind

2016

ABSTRACTA substantial number of new indefinite integrals involving the incomplete elliptic integral of the third kind are presented, together with a few integrals for the other two kinds of incomplete elliptic integral. These have been derived using a Lagrangian method which is based on the differential equations which these functions satisfy. Techniques for obtaining new integrals are discussed, together with transformations of the governing differential equations. Integrals involving products combining elliptic integrals of different kinds are also presented.

The role of the results of functional tests and psychological factors on prediction of injuries in adolescent female football players

2021

Football is a popular sport among adolescent females. Given the rate of injuries in female footballers, identifying factors that can predict injuries are important. These injuries are often caused by complex reasons. The aim of this study was to investigate if the combination of demographic (age, number of training and match play hours/week), psychosocial (perceived stress, adaptive coping strategies) and physiological factors (functional performance) can predict a traumatic injury in adolescent female footballers. A cohort consisting of 419 female football players aged 13–16 years was established. Baseline questionnaires covered potential risk factors for sport injuries, and measurem…

The Propeller Flap for Traumatic Distal Lower-Limb Reconstruction: Risk Factors, Pitfalls, and Recommendations.

2019

BACKGROUND Defects in the distal third of the leg are difficult to cover and often require free tissue transfer, even for defects of limited sizes. Propeller flaps have been designed specifically as an alternative to free tissue transfer but at times have been associated with unacceptably high complication rates. We therefore aimed to prospectively assess our own institutional experience with this technique and to define its role in lower-limb reconstruction. METHODS All patients who had been managed with reconstruction of the distal part of the leg with a propeller flap between 2014 and 2017 were included in the study. Demographic, clinical, and follow-up data on the patients and surgical …

Über die frühen Werke von Carl Gotthard Graß in der Akademischen Bibliothek der Universität Lettlands, über die Freundschaft, Antiquarismus in der Ge…

2020

Austrumbaltijas eksperts Karls Reinholds Kupfers

2022

Raksts par vācbaltu botāniķa Karla Reinholda Kupfera (1872-1935) dzīvi, Austrumbaltijas pētījumiem un citiem zinātniskajiem sasniegumiem.