Search results for "RNAs"
showing 10 items of 710 documents
Urinary MicroRNA Profiling Predicts the Development of Microalbuminuria in Patients with Type 1 Diabetes
2015
Microalbuminuria provides the earliest clinical marker of diabetic nephropathy among patients with Type 1 diabetes, yet it lacks sensitivity and specificity for early histological manifestations of disease. In recent years microRNAs have emerged as potential mediators in the pathogenesis of diabetes complications, suggesting a possible role in the diagnosis of early stage disease. We used quantiative polymerase chain reaction (qPCR) to evaluate the expression profile of 723 unique microRNAs in the normoalbuminuric urine of patients who did not develop nephropathy (n = 10) relative to patients who subsequently developed microalbuminuria (n = 17). Eighteen microRNAs were strongly associated w…
Implicación de miRNAs en la toxicidad mediada por expansiones de repeticiones CTG en Distrofia Miotónica
2015
La distrofia miotónica tipo 1 (DM1) es una enfermedad neuromuscular causa por la expansión del triplete CTG en la región 3’ no codificante del gen DMPK. Las expansiones CUG en los transcritos DMPK mutantes forman una estructura en horquilla que secuestra diferentes factores nucleares provocando su falta de función parcial y la desregulación de la expresión génica a diferentes niveles. La mayoría de los defectos en la expresión génica se han reproducido en animales modelo para la enfermedad que expresan transcritos con repeticiones CUG de manera independiente a DMPK. En este trabajo nos propusimos analizar si un grupo de reguladores de la expresión génica está afectado por la toxicidad media…
Aproximación a la fraseología metalingüística del alemán : las locuciones verbales con reden, sagen y sprechen.
2005
rosafe@uv.es
Lexical Pragmatics: Relevance Theory and Generalized Conversational Implicatures
2003
maruenda@uv.es
Reusing Computer-oriented Lexica as Foreign-Language Electronic Dictionaries
2006
"Poet on Poet": Countee Cullen and Langston Hughes (Two Versions for an Aesthetic-Literary Theory)
2007
A Review on Focalization
2008
In narratology, focalization is defined as the angle via which things are seen in the narrative world; also it is accounted as an element present in all narrative genres. As an independent discipline, focalization starts with Gerard Genette, and it undergoes various modifications from classical narratology to post-classical narratology. In fact, there are two basic domains for the discussions of focalization: 1. Genette's theory, 2. Post-Genettean approaches. Accordingly, this article aims at introducing focalization and the related notions to it, plus reviewing Genette's and post-Genettean approaches, in addition to making a background on focalization in the modernist view.
The Role of Forums in the Construction and Development of the Teaching-Learning Discourse in the ESP Classroom. A New Autonomising Tool within the La…
2006
A Corpus of American and British English: A Case Study of Slang
2009
This article is set against the background of linguistic Globalisation and its diffusion through the media. The mass media allow for linguistic shifts taking place in American English to spread to other World Englishes, as a result of an increasing trend towards colloquialisation, Americanisation and a more democratic model of (power) relationships. The present paper focuses on a corpus-based study that analyses the frequency of use of a series of American slang expressions. The study takes as a basis chiefly audiovisual corpora in parallel to which real linguistic data (drawn from a survey on slang) are examined. Results provide evidence of the so called Americanisation of other World Engl…