Search results for "ROH"
showing 10 items of 730 documents
From Feynman–Kac formulae to numerical stochastic homogenization in electrical impedance tomography
2016
In this paper, we use the theory of symmetric Dirichlet forms to derive Feynman–Kac formulae for the forward problem of electrical impedance tomography with possibly anisotropic, merely measurable conductivities corresponding to different electrode models on bounded Lipschitz domains. Subsequently, we employ these Feynman–Kac formulae to rigorously justify stochastic homogenization in the case of a stochastic boundary value problem arising from an inverse anomaly detection problem. Motivated by this theoretical result, we prove an estimate for the speed of convergence of the projected mean-square displacement of the underlying process which may serve as the theoretical foundation for the de…
A subset of flavaglines inhibits KRAS nanoclustering and activation.
2020
The RAS oncogenes are frequently mutated in human cancers and among the three isoforms (KRAS, HRAS and NRAS), KRAS is the most frequently mutated oncogene. Here, we demonstrate that a subset of flavaglines, a class of natural anti-tumour drugs and chemical ligands of prohibitins, inhibit RAS GTP loading and oncogene activation in cells at nanomolar concentrations. Treatment with rocaglamide, the first discovered flavagline, inhibited the nanoclustering of KRAS, but not HRAS and NRAS, at specific phospholipid-enriched plasma membrane domains. We further demonstrate that plasma membrane-associated prohibitins directly interact with KRAS, phosphatidylserine and phosphatidic acid, and these int…
El castigo penal del posesión y consumo de drogas para uso propio: el caso de Polonia
2021
El objetivo de este trabajo era investigar sobre la política penal sobre la posesión de drogas y, en particular, en los efectos de la prohibición penal de la posesión de drogas. El tema de la política penal sobre drogas es muy amplio. Pero en esta tesis he analizado la política penal prohibicionista, tal y como existe en Polonia, y he centrado atención en un solo elemento de esta política, pero uno muy importante y crucial: la posesión de drogas. Después, he abordado la cuestión de la posesión de drogas en Polonia, utilizando para ello cuatro perspectivas diferentes: la histórica, la sociológica y médica, la jurídica y, la más importante, la criminológica, para ver cómo funciona en la práct…
De la prohibición del terrorismo on-line : una reflexión constitucional
2021
The paper thinks out loud on the banning of the terrorist´s contents on the Internet, specifically within the international and national legal framework, with the interpretation given by the European Court´s of Human Right case-law and our Constitutional Court´s case-law.
¿El Estado de Derecho en peligro? El juez constitucional contra la Constitución y a favor de la reelección presidencial indefinida : caso Bolivia
2021
In Bolivia, the third term and the habilitation of former President Evo Morales to the 2019 presidential elections was allowed with the acquiescence of the Plurinational Constitutional Court. Despite the fact that the Constitution prohibited it and there was a referendum that rejected indefinite presidential re-election. This occurred through the judicialization of politics that produced a non-formal reform of the Constitution producing a case of abusive constitutionalism and the destabilization of the rule of law.
Derecho y conciencia en Antígona: Una respuesta atemporal a los conflictos de familia
2018
El presente artículo aborda la importancia de la familia en Antígona, de Sófocles. Ante el Decreto de Creonte, por el que se prohibía, bajo pena de muerte, enterrar y llorar a Polinices, su hermana ?Antígona ? no duda en afirmar que por encima de las leyes del Estado está la ley de los dioses y la ley que dicta su conciencia, la que le exige anteponer los lazos familiares al orden público. Un acto de desobediencia civil que le conducirá a muerte.
Latvijas Vēstures Institūta Žurnāls. 2021, Nr. 1 (113)
2021
LU Latvijas vēstures institūta LU ilgtermiņa saistību izpilde 2020.-2022. g. ("Latvijas Vēstures Institūta Žurnāls")
Cuatro fórmulas de posicionamiento frente a las drogas
2010
Las políticas públicas en materia de drogas se encuentran actualmente en una encrucijada. A través de las siguientes páginas se ofrece una reflexión sobre cuatro tipos de posicionamiento teórico, cuatro formas diferentes de entender cuál es el papel que en este conflicto, deben adoptar los Estados. A modo de tipificación de esas perspectivas posibles, se ofrece una propuesta de clasificación distribuida en cuatro posiciones: - Prohibicionismo ideológico - Prohibicionismo político - Disminución del riesgo y reducción del daño - Negación de riesgos y daños Public policies on drugs are currently in a crossroad. Throughout the following pages four theoretical positions are examined, four differ…
Intestinal tuberculosis in a child living in a country with a low incidence of tuberculosis : a case report
2014
Background: Relatively common in adults, intestinal tuberculosis is considered rare in children and adolescents. The protean manifestations of intestinal tuberculosis mean that the diagnosis is often delayed (sometimes even for years), thus leading to increased mortality and unnecessary surgery. The main diagnostic dilemma is to differentiate intestinal tuberculosis and Crohn’s disease because a misdiagnosis can have dramatic consequences. Case presentation: A 13-year-old Caucasian, Italian female adolescent attended the Emergency Department complaining of abdominal pain, a fever of up to 38°C, night sweats, diarrhea with blood in stool, and a weight loss of about three kilograms over the p…
Ag11(SG)7 : A New Cluster Identified by Mass Spectrometry and Optical Spectroscopy
2014
We report a one-step and high yield synthesis of a red-luminescent silver cluster with the molecular formula, Ag11(SG)7 (SG: glutathionate) via reduction of silver ions by sodium borohydride in the presence of the tripeptide, glutathione (GSH). The as-prepared cluster shows prominent absorption features at 485 and 625 nm in its UV-vis absorption spectrum. Aging of the as-prepared cluster solution led to the disappearance of the 625 nm peak, followed by broadening of the 485 nm peak to give three maxima at ?487, 437, and 393 nm in its absorption spectrum. These peaks remain unchanged even after polyacrylamide gel electrophoresis (PAGE), where a single band was observed confirming high purity…