Search results for "ROLE"
showing 10 items of 1994 documents
Indications of PCSK9 inhibitors in clinical practice. Recommendations of the Spanish Society of Arteriosclerosis (SEA), 2019
2019
A group of experts convened by the Spanish Society of Arteriosclerosis (SEA) has been in charge of updating the SEA document on the indications of PCSK9 inhibitors (PCSK9i) in clinical practice that was published in 2016. This update is justified by the fact that the data from clinical trials carried out on a large scale with PCSK9i have shown that in addition to their high potency to lower atherogenic cholesterol, they reduce the risk of atherosclerotic cardiovascular disease, both in patients with stable disease, and with recent disease, and with a high degree of security. This update provides the recommendations and level of evidence for the prescription of iPCSK9 in patients with homozy…
Repair of a spinal pseudomeningocele in a delayed postsurgical cerebrospinal fluid leak using titanium U-clips: Technical note
2020
Abstract Introduction Chronic cerebrospinal fluid leak (CCFL) represents a possible event following spine surgery, with an incidence rate ranging from 5 to 18%. In literature have been reported few modification techniques that involved the use of titanium U-clips with the aim to reduce dural traumatism during its closure but only after non-accidental durotomy. Case illustration We report the case of a 47-year-old female with history of L5-S1 microsurgical discectomy. After one year the patient was admitted to our unit because she presented progressive skin swelling in the lumbar region, intermittent headache and recurrent episodes of lipothymia. One-year MRI showed a voluminous subcutaneous…
Statins stimulate the production of a soluble form of the receptor for advanced glycation end products
2013
The beneficial effects of statin therapy in the reduction of cardiovascular pathogenesis, atherosclerosis, and diabetic complications are well known. The receptor for advanced glycation end products (RAGE) plays an important role in the progression of these diseases. In contrast, soluble forms of RAGE act as decoys for RAGE ligands and may prevent the development of RAGE-mediated disorders. Soluble forms of RAGE are either produced by alternative splicing [endogenous secretory RAGE (esRAGE)] or by proteolytic shedding mediated by metalloproteinases [shed RAGE (sRAGE)]. Therefore we analyzed whether statins influence the production of soluble RAGE. Lovastatin treatment of either mouse alveol…
Depression is Associated with Moderate-Intensity Physical Activity Among College Students During the COVID-19 Pandemic: Differs by Activity Level, Ge…
2020
Jingyuan Lin,1,* Tianyou Guo,2,* Benjamin Becker,3 Qian Yu,2 Si-Tong Chen,4 Stubbs Brendon,5 Md Mahbub Hossain,6 Paolo M Cunha,7 Fernanda Cunha Soares,8 Nicola Veronese,9 Jane Jie Yu,10 Igor Grabovac,11 Lee Smith,12 Albert Yeung,13 Liye Zou,2 Hong Li1 1Research Centre of Brain Function and Psychological Science; Center for Language and Brain, Shenzhen Institute of Neuroscience; Shenzhen Key Laboratory of Affective and Social Cognitive Science, School of Psychology, Shenzhen University, Shenzhen, 518060, People’s Republic of China; 2Exercise and Mental Health Laboratory, School of Psychology, Shenzhen University, Shenzhen 518060, People’s Republic of China; 3The Clinical …
A pyrroloquinazoline derivative with anti-inflammatory and analgesic activity by dual inhibition of cyclo-oxygenase-2 and 5-lipoxygenase
2002
Abstract In a previous study, we reported a new pyrroloquinazoline derivative, 3-(4′-acetoxy-3′,5′-dimethoxy)benzylidene-1,2-dihydropyrrolo[2,1- b ]quinazoline-9-one (PQ), which inhibited human purified 5-lipoxygenase activity and prostaglandin E 2 release in lipopolysaccharide-stimulated RAW 264.7 cells. In the present work, we show that PQ inhibits cyclo-oxygenase-2 activity in intact cell assays (human monocytes) and purified enzyme preparations (ovine isoenzymes) without affecting cyclo-oxygenase-1 activity. This behaviour was confirmed in vivo by using the zymosan-injected mouse air pouch model, where PQ caused a marked reduction in cell migration and leukotriene B 4 levels at 4 h, as …
Managing Peripheral Artery Disease in Diabetic Patients: A Questionnaire Survey from Vascular Centers of the Mediterranean Federation for the Advanci…
2020
Background The Mediterranean Federation for the Advancing of Vascular Surgery (MeFAVS) was founded on October 1, 2018, to enhance cooperation among vascular professionals within Mediterranean countries. Due to its prominent social and economic impact on national health systems, diabetic arteriopathy has been selected as the very first topic to be investigated by the federation. Methods MeFAVS members were asked to reply to a questionnaire on the management of diabetic ischemic foot. Results were collected and analyzed statistically. The questionnaire consisted of 15 multiple choice answers regarding diabetic foot (DF) diagnosis and treatment. The questionnaire was submitted to 21 centers on…
Subjektīvā kontroles lokusa un emocionālās inteliģences ietekme uz izdegšanas sindromu Latvijas medicīnas studentiem un rezidentiem
2019
Izdegšanas sindromu veicina hronisks stress. Augsts emocionālais intelekts (EI) pasargā no izdegšanas. Internāls kontroles lokuss (KL), uzskats, ka dzīves notikumi ir atkarīgi no savas rīcības, prognozē zemāku izdegšanu. Mērķis: Izpētīt EI un KL ietekmi uz izdegšanas sindromu medicīnas studentiem un rezidentiem Latvijā. Uzdevumi: Noteikt izdegšanu, EI un KL Latvijas ārstniecības studentiem un rezidentiem un kā tie ietekmē izdegšanu. Materiāli un metodes: Medicīnas studenti un rezidenti šķērsgriezuma pētījumā brīvprātīgi, anonīmi aptaujāti ar sociāldemogrāfisko rādītāju aptauju, EI skalu (Schutte et al., 1998, Latvijā adaptējuši Reņģe un Ņižņika,2012), Internālā–Eksternālā KL skalu (Rotter, …
Ķīnas sociālais kredīts kā sabiedrības kontroles instruments
2022
Bakalaura darba “Ķīnas sociālais kredīts kā sabiedrības kontroles instrumets” mērķis ir noteikt, kādus naratīvus saistībā ar sociālo kredītu sistēmu veido vadošie Ķīnas un Āzijas ziņu portāli angļu valodā un noskaidort, vai šajos medijos tie ir atšķirīgi, atsevišķi, analizējot autoritārā, atkarīgā un demokrātiskā, neatkarīgā medja iekļautos naratīvus. Kā papildus mērķis ir izvirzīts notiekt, kādā veidā Ķīna, izmantojot medijus, ir spējīga kontrolēt sabiedrību, tajā notiekošos procesus, pilnībā radot jaunu dzīves vidi. Darba teorētiskajā daļā aprakstīta Ķīnas sociālā kredīta būtība, naratīva teorija un naratoloģijas pielietojums, aprakstīts, kā masu mediji spēj būt sociālās kontroles instrum…
CCDC 2149627: Experimental Crystal Structure Determination
2022
Related Article: Adrian Laviós, Amparo Sanz-Marco, Carlos Vila, M. Carmen Muñoz, José R. Pedro, Gonzalo Blay|2022|Org.Lett.|24|2149|doi:10.1021/acs.orglett.2c00427
Assessment of microalgae species, biomass, and distribution from spectral images using a convolution neural network
2022
AbstractEffective monitoring of microalgae growth is crucial for environmental observation, while the applications of this monitoring could also be expanded to commercial and research-focused microalgae cultivation. Currently, the distinctive optical properties of different microalgae groups are targeted for monitoring. Since different microalgae can grow together, their spectral signals are mixed with ambient properties, making estimations of species biomasses a challenging task. In this study, we cultured five different microalgae and monitored their growth with a mobile spectral imager in three separate experiments. We trained and validated a one-dimensional convolution neural network by…